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A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 31 Dec 2021

Guest Editor(s)

  • Dar-In Tai, MD, PhD
    Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.

    Website | E-mail

Special Issue Introduction

Persistent infection of hepatitis B virus (HBV) is the first step toward HBV-related hepatocarcinogenesis. Among HBV carriers, only about 25% will run into cirrhosis and/or hepatocellular carcinoma. We do not know exactly why some of the patients may run into more aggressive diseases from clinical studies. We observed that being unable to terminate HBV replication could be the main risk factor for hepatocarcinogenesis. Both HBV carrier and hepatocellular carcinoma can be found in clusters in the family. Genetic factors are supposed to play roles in persistent HBV infection and hepatocarcinogenesis. Recent advances in sequencing and genotyping methodology have made genetic exploration more efficient. Many genomes wide association studies had open windows to understand genetic roles in HBV-related diseases. This special issue encourages authors to contribute original or review manuscripts in different aspects, perspective, opinion, commentary and other manuscript types will also be welcome.

The following paper topics are to be covered in this special issue:
1.Role of human leukocyte antigen-related genetic polymorphism on HBV viral loads.
2.Innate immunity-related genetic polymorphism on HBV viral loads. 3.Genetic polymorphism associated with interferon therapy.
4.Genetic polymorphism associated with nucleot(s)ide therapy.
5.Genetic polymorphism associated with hepatitis B e-antigen (HBeAg) clearance.
6.Genetic polymorphism associated with delayed (hepatitis B surface antigen) HBsAg clearance in chronic hepatitis B infection.
7.Genetic polymorphism associated with HBV disease progression.

Submission Deadline

31 Dec 2021

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
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Submission Deadline: 31 Dec 2021
Contacts: Victoria Lee, Assistant Editor,

Published Articles

This special issue is now open for submission.
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