Editor's Choice
Open Access
Review
Evaluation and impact of different biomarkers for early detection of hepatocellular carcinoma
Worldwide, hepatocellular carcinoma (HCC) is a frequent complication of liver diseases and remains a major cause of cancer-related mortality. In addition, the prevalence of nonalcoholic steatohepatitis (NASH) as prerequisite of hepatocarcinogenesis, even in the absence of cirrhosis, is rising......
This article belongs to the Special Issue Research on the Risk Factors of Liver Cirrhosis Complicated with HCC
Hepatoma Res 2020;6:62.
Published on: 1 Sep 2020
Viewed: 414 Downloaded: 81
Open Access
Review
Pathomolecular characterization of HCC in non-cirrhotic livers
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and usually arises in cirrhotic livers. Increasingly, it is diagnosed in non-cirrhotic livers. A variety of risk factors and etiologies can trigger the development of HCC in non-fibrotic and non-cirrhotic backgrounds. The......
This article belongs to the Special Issue New Perspectives on the Diagnosis and Management of HCC
Hepatoma Res 2020;6:47.
Published on: 7 Aug 2020
Viewed: 337 Downloaded: 68
Open Access
Review
Management of concomitant hepatocellular carcinoma and chronic hepatitis C: a review
Our comprehensive review focuses on the treatment of hepatitis C virus in the context of hepatocellular carcinoma and vice versa, highlighting the ongoing complexity of this clinical scenario. There remain multiple unanswered questions when considering the management of these complex patients......
Hepatoma Res 2019;5:28.
Published on: 29 Jul 2019
Viewed: 5084 Downloaded: 1036
Open Access
Original Article
A dimethylbromobenzene-cysteine stapled peptide dual inhibitor of the p53-MDM2/MDMX interactions
Aim: Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet, the current treatment for HCC is less effective than those used against other cancers. Transcription factor p53 induces cell cycle arrest and apoptosis in response to DNA damage......
Hepatoma Res 2019;5:5.
Published on: 13 Feb 2019
Viewed: 1837 Downloaded: 306
Open Access
Commentary
From nonalcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease: is...
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease in many parts of the world, causing considerable liver-related (steatohepatitis, cirrhosis, liver failure and hepatocellular carcinoma) and extra-hepatic morbidity and mortality (mainly cardiovascular......
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:64.
Published on: 12 Sep 2020
Viewed: 542 Downloaded: 93
Open Access
Review
Advances in surface markers of liver cancer stem cell
Liver cancer stem cells (LCSCs), a small subpopulation that constitutes liver cancer heterogeneity, play a vital role in cancer initiation, invasion, recurrence, metastasis, and resistance to chemo-radiotherapy. It is believed that therapies targeting LCSCs can improve the efficacy of......
This article belongs to the Special Issue Advances in the Early Diagnosis of HCC
Hepatoma Res 2019;5:27.
Published on: 23 Jul 2019
Viewed: 2073 Downloaded: 441
Open Access
Review
Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma
Non-alcoholic fatty liver disease (NAFLD) and its advanced complication, non-alcoholic steatohepatitis (NASH), have become leading causes of hepatocellular carcinoma (HCC) worldwide. In this review, we discuss the role of metabolic, gut microbial, immune and endocrine mediators which promote......
This article belongs to the Special Issue Liver Cancer in Alcoholic and Metabolic Liver Diseases
Hepatoma Res 2019;5:42.
Published on: 11 Dec 2019
Viewed: 2848 Downloaded: 704
Open Access
Review
Circulating tumor DNAs and non-coding RNAs as potential biomarkers for hepatocellular carcinoma...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide and despite improvement in therapeutic approaches, prognosis remains poor. This can be partly attributed to the fact that the majority of HCCs are diagnosed at intermediate or advanced stages.......
This article belongs to the Special Issue Advances in the Early Diagnosis of HCC
Hepatoma Res 2019;5:6.
Published on: 19 Feb 2019
Viewed: 3249 Downloaded: 545
Open Access
Review
The use of cell free DNA in the diagnosis of HCC
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is associated with high mortality. The currently used methods for diagnosing HCC, including imaging modalities and liver biopsy, detect tumors at a relatively advanced stage or are invasive. Non-invasive......
This article belongs to the Special Issue Advances in the Early Diagnosis of HCC
Hepatoma Res 2019;5:34.
Published on: 23 Sep 2019
Viewed: 3149 Downloaded: 1218
Articles
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Open Access ReviewCutaneous toxicities of targeted therapies in the treatment of hepatocellular carcinoma
Tarik Silk, Jennifer WuThis article belongs to the Special Issue Targeted Therapy for Liver CancerHepatoma Res 2020;6:73.Published on: 16 Oct 2020 Viewed: 136 Downloaded: 24 -
Open Access Original ArticleThe transcontinental variability of nonalcoholic fatty liver disease
Claudia P. Oliveira, ... Arun J. SanyalThis article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver DiseaseHepatoma Res 2020;6:72.Published on: 12 Oct 2020 Viewed: 133 Downloaded: 21 -
Open Access Original ArticlePost liver transplant recurrence in patients with hepatocellular carcinoma: not necessarily the end of the road!
Prashant Bhangui, ... AS SoinThis article belongs to the Special Issue Living Donor Liver Transplantation for Hepatocellular CarcinomaHepatoma Res 2020;6:71.Published on: 12 Oct 2020 Viewed: 226 Downloaded: 14 -
Open Access Review
Systemic therapy for advanced cholangiocarcinoma: new options on the horizon
Saleh A. Alqahtani, Massimo ColomboThis article belongs to the Special Issue Targeted Therapy for Liver CancerHepatoma Res 2020;6:70.Published on: 12 Oct 2020 Viewed: 261 Downloaded: 49 -
Open Access ReviewBeneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review
Alessio Calabrò, ... Ludovico AbenavoliThis article belongs to the Special Issue Diet, Liver Diseases, Liver Cancer: Prevention from the SourceHepatoma Res 2020;6:69.Published on: 12 Oct 2020 Viewed: 106 Downloaded: 26 -
Open Access ReviewImmunotherapy of hepatocellular carcinoma with infection of hepatitis B or C virus
Cecilia Monge Bonilla, ... Changqing XieThis article belongs to the Special Issue Immunotherapy and Immunotherapy Biomarkers for Hepatocellular CarcinomaHepatoma Res 2020;6:68.Published on: 12 Oct 2020 Viewed: 126 Downloaded: 26 -
Open Access Original ArticlePrognostic ability of inflammation-based markers in radioembolization for hepatocellular carcinoma
Grant Yoneoka, ... Linda L. WongHepatoma Res 2020;6:67.Published on: 12 Oct 2020 Viewed: 63 Downloaded: 12 -
Open Access Original ArticleStereotactic body radiation therapy for primary liver tumors with adverse factors
Takuya Shimizuguchi, ... Katsuyuki KarasawaThis article belongs to the Special Issue Radiation Therapy in Asia-Pacific Patients with Hepatocellular CarcinomaHepatoma Res 2020;6:66.Published on: 12 Oct 2020 Viewed: 73 Downloaded: 28
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Open Access Review
Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma
Hanaa A. Hassan, ... Anmar F. AzhariHepatoma Res 2016;2:216-223.Published on: 5 Aug 2016 Viewed: 102260 Downloaded: 960 -
Open Access ReviewHepatitis B virus molecular biology and pathogenesis
R. Jason Lamontagne, ... Michael J. BouchardHepatoma Res 2016;2:163-186.Published on: 1 Jul 2016 Viewed: 81432 Downloaded: 3770 -
Open Access Editorial
Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?
Jing Li, ... Yi-Qun YanThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:109-110.Published on: 15 Oct 2015 Viewed: 43717 Downloaded: 806 -
Open Access Review"PERISH" flowchart for selection of the patients with resectable hepatocellular carcinoma
Cuneyt Kayaalp, ... Mehmet CaglikulekciHepatoma Res 2015;1:165-170.Published on: 15 Oct 2015 Viewed: 33138 Downloaded: 892 -
Open Access ReviewRadiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients
Alba Castán, ... Alejandro SerrabloHepatoma Res 2017;3:1-17.Published on: 12 Jan 2017 Viewed: 28841 Downloaded: 1112 -
Open Access ReviewPhysiological potential of cytokines and liver damages
Fathia A. Mannaa, Khaled G. Abdel-WahhabHepatoma Res 2016;2:131-143.Published on: 1 Jun 2016 Viewed: 26675 Downloaded: 1322 -
Open Access Review
Curcumin: an adjuvant therapeutic remedy for liver cancer
Shilpa Sharma, ... Devendra K. GuptaThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2016;2:62-70.Published on: 9 Mar 2016 Viewed: 24363 Downloaded: 762 -
Open Access Review
Diet and nutrition therapy in pre-liver transplant patients
Neha Bakshi, Kalyani SinghHepatoma Res 2016;2:207-215.Published on: 5 Aug 2016 Viewed: 19379 Downloaded: 762
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Open Access Review
Hepatitis B virus molecular biology and pathogenesis
R. Jason Lamontagne, ... Michael J. BouchardHepatoma Res 2016;2:163-186.Published on: 1 Jul 2016 Viewed: 81432 Downloaded: 3770 -
Open Access Review
Immunotherapy for hepatocellular carcinoma: the force awakens in HCC?
Lynn G. Feun, ... Niramol SavarajThis article belongs to the Special Issue Novel Approaches for HCCHepatoma Res 2017;3:43-51.Published on: 22 Mar 2017 Viewed: 6708 Downloaded: 1502 -
Open Access Review
Management of advanced hepatocellular carcinoma: review of current and potential therapies
Asmaa Gomaa, Imam WakedHepatoma Res 2017;3:112-122.Published on: 15 Jun 2017 Viewed: 12611 Downloaded: 1475 -
Open Access ReviewIntrahepatic cholangiocarcinoma: review and update
Vincenzo Cardinale, ... Domenico AlvaroThis article belongs to the Special Issue New Insights in Liver CancerHepatoma Res 2018;4:20.Published on: 19 Jun 2018 Viewed: 9559 Downloaded: 1463 -
Open Access Review
Physiological potential of cytokines and liver damages
Fathia A. Mannaa, Khaled G. Abdel-WahhabHepatoma Res 2016;2:131-143.Published on: 1 Jun 2016 Viewed: 26675 Downloaded: 1322 -
Open Access Minireview
Updates on hepatorenal syndrome and strategies bridging to liver transplantation
Chung Yeung Cheung, Kenneth S.H. ChokHepatoma Res 2017;3:67-72.Published on: 12 Apr 2017 Viewed: 14030 Downloaded: 1315 -
Open Access Review
Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma
Mohamed A. Hamzawy, ... Mosaad A. Abdel-WahhabThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:111-118.Published on: 15 Oct 2015 Viewed: 11208 Downloaded: 1221 -
Open Access ReviewThe use of cell free DNA in the diagnosis of HCC
Bubu A. Banini, Arun J. SanyalThis article belongs to the Special Issue Advances in the Early Diagnosis of HCCHepatoma Res 2019;5:34.Published on: 23 Sep 2019 Viewed: 3149 Downloaded: 1218
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Open Access Review
Hepatitis B virus molecular biology and pathogenesis
R. Jason Lamontagne, ... Michael J. BouchardHepatoma Res 2016;2:163-186.Published on: 1 Jul 2016 Viewed: 81432 Downloaded: 3770 -
Open Access Original ArticleGender differences in hepatocellular cancer: disparities in nonalcoholic fatty liver disease/steatohepatitis and liver transplantation
Eric M. Wu, ... Sumodh KalathilHepatoma Res 2018;4:66.Published on: 18 Oct 2018 Viewed: 3747 Downloaded: 521 -
Open Access Editorial
Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique?
Paola Tombesi, ... Sergio SartoriHepatoma Res 2015;1:52-57.Published on: 15 Jul 2015 Viewed: 12579 Downloaded: 1098 -
Open Access Original Article
Detection of urine DNA markers for monitoring recurrent hepatocellular carcinoma
Hie-Won Hann, ... Ying-Hsiu SuHepatoma Res 2017;3:105-111.Published on: 6 Jun 2017 Viewed: 4232 Downloaded: 868 -
Open Access ReviewRole of early growth response 1 in liver metabolism and liver cancer
Nancy Magee, Yuxia ZhangHepatoma Res 2017;3:268-277.Published on: 20 Nov 2017 Viewed: 4543 Downloaded: 504 -
Open Access ReviewOxidative stress and hepatocarcinogenesis
Ying Fu, Fung-Lung ChungThis article belongs to the Special Issue Molecular Mechanism of Hepatocellular CarcinomaHepatoma Res 2018;4:39.Published on: 1 Aug 2018 Viewed: 5246 Downloaded: 1102 -
Open Access Original ArticleIdentifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies
Jing Shen, ... Regina M. SantellaHepatoma Res 2016;2:151-162.Published on: 1 Jun 2016 Viewed: 10457 Downloaded: 879 -
Open Access Opinion
Elimination of hepatitis from Pakistan by 2030: is it possible?
Yasir Waheed, Masood SiddiqThis article belongs to the Special Issue What More We can do on Hepatitis C?Hepatoma Res 2018;4:45.Published on: 14 Aug 2018 Viewed: 4143 Downloaded: 263
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Open Access Editorial
Natural products and hepatocellular carcinoma
Mosaad A. Abdel-WahhabThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:107-108.Published on: 15 Oct 2015 Viewed: 5673 Downloaded: 436 -
Open Access Editorial
Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?
Jing Li, ... Yi-Qun YanThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:109-110.Published on: 15 Oct 2015 Viewed: 43717 Downloaded: 806 -
Open Access Review
Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma
Mohamed A. Hamzawy, ... Mosaad A. Abdel-WahhabThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:111-118.Published on: 15 Oct 2015 Viewed: 11208 Downloaded: 1221 -
Open Access Review
Natural products and hepatocellular carcinoma: a review
Asma M. Alnajjar, Hussien A. ElsiesyThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:119-124.Published on: 15 Oct 2015 Viewed: 10297 Downloaded: 913 -
Open Access Original ArticlePreventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats
Fathia A. Mannaa, ... Saida G. MohammedThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:125-135.Published on: 15 Oct 2015 Viewed: 12557 Downloaded: 735 -
Open Access Original ArticleProtective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells
Mohamed I. M. Ibrahim, ... Mosaad A. Abdel-WahhabThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:136-146.Published on: 15 Oct 2015 Viewed: 7858 Downloaded: 494 -
Open Access Original ArticleSynergistically curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma
Hanaa A. Hassan, ... Mahmoud M. AmrThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2015;1:147-154.Published on: 15 Oct 2015 Viewed: 12873 Downloaded: 834 -
Open Access Original ArticleDietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet
Mosaad A. Abdel-Wahhab, ... Bertrand H. RihnThis article belongs to the Special Issue Natural Products and Hepatocellular CarcinomaHepatoma Res 2016;2:78-86.Published on: 9 Mar 2016 Viewed: 4927 Downloaded: 476
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Hepatoma Research is published by OAE Publishing Inc.
