Hot Keywords
non-alcoholic fatty liver disease epidemiology microenvironment nonalcoholic steatohepatitis transplantation cholangiocarcinoma direct-acting antiviral immunotherapy hepatitis B hepatitis C liver resection imaging cancer stem cell diagnosis gene cirrhosis biomarker recurrence

Topic: Molecular Mechanisms of Liver Cancer Cell Proliferation, Invasion and Metastasis

A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 15 Feb 2021

Guest Editor(s)

  • Isabel Fabregat, PhD
    Bellvitge Biomedical Research Institute (IDIBELL), CIBEREHD and University of Barcelona, L’Hospitalet, Barcelona, Spain.

    Website | E-mail

Special Issue Introduction

Liver cancer is one of the most commonly diagnosed cancers and one of the leading causes of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75%-85% of primary liver cancers and is the consequence of aberrant growth of hepatocytes, the most abundant liver cell type. Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for more than 15% of all primary liver cancers. Hepatoblastoma (HB) is the most common malignant liver tumor in children and accounts for approximately 1% of all pediatric tumors. A characteristic shared by most frequent types of primary liver cancers is the lack of efficient therapeutic tools and their high refractoriness to chemotherapy. There is a need to better understand the molecular mechanisms responsible for the initiation, progression and dissemination of these tumors to progress in precision medicine for patients. This special issue encourages authors to contribute original or review manuscripts in different aspects. Perspective, opinion, commentary will be also welcome.

Proposed paper titles:
1. Deregulation of mechanisms involved in cell proliferation and death
2. Molecular mechanism contributing to alterations in cell adhesion, migration, invasion
3. Signalling pathways involved in cell adhesion, migration, invasion
4. Intercellular communication among tumor cells or tumor-stromal cells
5. Molecular mechanisms conferring resistance to therapeutic drugs
6. Molecular mechanisms conferring resistance to immune surveillance
7. Relevance of metabolism reprogramming in tumor progression, dissemination and resistance to therapy
8. Redox biology of the liver tumor cell and its relevance to tumor progression, dissemination and resistance to therapy


1. Matias A. Avila  Hepatology Program, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
2. Srikanta Dash  Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
3. Almudena Porras  Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Complutense University of Madrid. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
4. Carmen Berasain  Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Pamplona, Spain.
5. Francesco Dituri  National Institute of Gastroenterology "S. de Bellis", Research Hospital, Castellana Grotte, Italy.
6. Matiullah Khan  Department of Pathology, AIMST University, Bedong, Malaysia.
7. Yoshihiro Shidoji  Molecular and Cellular Biology, Graduate School of Human Health Science, University of Nagasaki, Nagayo, Nagasaki, Japan.
8. Cheng-Maw Ho  Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
9. Soma Banerjee  Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, West Bengal, India.
10. Mehmet Ozturk  Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey.
11. Preeyanat Vongchan  Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
12. Consolato Sergi  Department of Pediatrics and Department of Laboratory Medicine and Pathology, The University of Alberta, Edmonton, Alberta, Canada.
The list is arranged in no particular order and being updated.

Submission Deadline

15 Feb 2021

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 15 Feb 2021
Contacts: Delphine Wong, Assistant Editor,

Published Articles

© 2016-2022 OAE Publishing Inc., except certain content provided by third parties