fig1

Figure 1. The major mechanisms of tumor resistance. (A) Biological barriers^[48]. Reproduced with permission from ref^[48]. Copyright 2020 American Chemical Society. (B) Drug inactivation^[40]. Reproduced with permission from ref^[40]. Copyright 2021 American Chemical Society. (C) DNA damage repair^[61]. Reproduced with permission from ref^[61]. Copyright 2022 the authors. (D) Immune evasion^[69]. Reproduced with permission from ref^[69]. Copyright 2020 Science.