fig1

Figure 1. Tumor microenvironment influence on effector lymphocytes. CCA: cholangiocarcinoma; PD-1: programmed cell death; CTLA4: cytotoxic T-lymphocyte-associated protein 4; NKs: natural killers; IL-10: interleukin-10; TGFβ: transforming growth factor β; MDSCs: myeloid-derived suppressor cells; B: B lymphocytes; CD 8⁺: CD 8⁺ lymphocytes; CD 4⁺: CD 4⁺ lymphocytes; Treg: regulatory T cells; DCs: dendritic cells; CAFs: cancer-associated fibroblasts; TAMs: tumor-associated macrophages; TANs: tumor-associated neutrophils; CCL2: C-C motif chemokine ligand 2.