fig2

Figure 2. Racial differences in the mutational signatures of HCC. (A) The distribution of somatic mutations per megabase of signatures. (B) Comparison of prevalence of signatures among Asian-Korea, Asian-TCGA, White-TCGA, and Black-TCGA. Wilcoxon signed-rank test and Bonferroni corrected: P > 0.05, 0.01 < P ≤ 0.05, 0.001 < P ≤ 0.01, 0.0001 < P ≤ 0.001, and 0 < P ≤ 0.0001 are shown as ns, *, **, ***, and ****, respectively. (C) Unsupervised clustering of HCC patients based on the fractions of seven mutational signatures in each patient.