fig5

Figure 5. CRK and CRKL mRNA expression in HCC and CCA patients and its relationship with survival. Box plots (left) show CRK and CRKL mRNA levels expressed as log2 (TPM + 1) in tumor (red) and adjacent liver non-pathological samples (blue) samples. Kaplan-Meier curves show overall survival (middle) and disease-free survival probability (right) comparing patients with high (red) vs. low (blue) expression levels of each analyzed gene (median TPM cutoff was chosen). All data were generated through GEPIA2 portal (Gene Expression Profiling Interactive Analysis; http://gepia2.cancer-pku.cn/#index). Log rank value is indicated for each curve. GEPIA2 mRNASeq dataset analyses are based on UCSC Xena project (http://xena.ucsc.edu) TCGA-LIHC and TCGA-CHOL, for HCC (50 normal and 371 tumor samples) and CCA (9 normal and 36 tumor samples) patients, respectively. Results are considered statistically significant for P values ≤ 0.05(*). HCC: Hepatocellular carcinoma; CCA: cholangiocarcinoma.