fig4

Figure 4. RAPGEF1 and RAP GTPases mRNA expression in CCA patients and its relationship with survival. From top to bottom, RAPGEF1, RAP1A, -1B, -2A, -2B and -2C: Box plots (left) show mRNA levels expressed as log2 (TPM + 1) in tumor (red) and adjacent liver non-pathological samples (blue) samples. Kaplan-Meier curves show overall survival (middle) and disease-free cumulative survival (right), comparing patients with high (red) vs. low (blue) expression levels of each analyzed gene (median TPM cutoff was chosen). All data were generated through GEPIA2 portal (Gene Expression Profiling Interactive Analysis; http://gepia2.cancer-pku.cn/#index). Log rank value is indicated for each curve. GEPIA2 mRNASeq dataset analyses are based on UCSC Xena project (http://xena.ucsc.edu) TCGA-CHOL (9 normal and 36 tumor samples) from patients. Results are considered statistically significant for P values ≤ 0.05(*). CCA: Cholangiocarcinoma.