fig2

Figure 2. RAP GTPases mRNA expression in HCC patients and its relationship with survival. From top to bottom, RAP1A, -1B, -2A, -2B and -2C: Box plots (left) show mRNA levels expressed as log2 (TPM + 1) in tumor (red) and adjacent liver non-pathological (blue) samples. Kaplan-Meier curves show overall survival (middle) and disease-free cumulative survival (right), comparing patients with high (red) vs. low (blue) expression levels for each analyzed gene (median TPM cutoff was chosen). All data were generated through GEPIA2 portal (Gene Expression Profiling Interactive Analysis; http://gepia2.cancer-pku.cn/#index). Log rank value is indicated for each curve. GEPIA2 mRNASeq dataset analyses are based on UCSC Xena project (http://xena.ucsc.edu) TCGA-LIHC [Liver Hepatocellular Carcinoma (HCC)] cohort for (50 normal and 371 tumor samples) patients. Results are considered statistically significant for P values ≤ 0.05 (*).