fig2

Figure 2. TP53 missense mutations found in human cancers and liver cancer. The main mutated codons were placed on the p53 protein. A: main somatic mutations found in all cancer types (more than 100 mutations listed); B: main mutations found in HCC (more than 4 mutations listed). Source, IARC TP53 database R20. TA: transactivation domain; DBD: DNA binding domain; OD: oligomerization domain. The position of the first and the last p53 aminoacids are noted in red. Deletions, insertions and mutations in introns have not been included in the cartoon