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Figure 5. Kaplan-Meier survival studies. Disease specific OS was analyzed in 69 valid hepatocellular carcinoma (HCC) samples in relation to the presence of KDM2A immunopositivity in intranuclear inclusions (A) and in the cytoplasm (B). Additionally, recurrence-free survival was examined in 47 valid HCC samples in relation to the presence of KDM2A immunopositivity in the cytoplasm of tumor (A) and in adjacent normal tissue (B). We counted inclusions in a standardized area of 23.5 mm² (ten serial sections of each case). Only cases with evaluable material on all ten serial sections were included. Cases containing at least one membrane-bound nuclear inclusion were considered positive; P ≤ 0.05 was defined as statistically significant