fig4

Figure 4. Inhibition of PREX2proteasomal degradation by GNMT. AKT: Murine thymoma viral oncogene homolog; GNMT: glycine N-methyltransferase; HectH9: E3 ubiquitin ligase; PI3K: phosphoinositide-3-kinase; PIP2: phosphorylating phosphatidylinositol-4,5-bisphosphatde; PIP3: phosphatidylinositol-3,4,5-triphosphate; PREX2: phosphatidylinositol 3,4,5-trisphosphatedependent Rac exchanger 2.