fig3

Figure 3. Mechanisms of inhibition of hepatocellular carcinoma growth by glycine methyltransferase. The inhibition of the RAPTOR/mTOR complex, impedes S6K1 activation and the feedback negative effect of S6K1 on the PI3K/AKT axis mediated by IRS. GNMT: glycine N-methyltransferase; mTOR: mechanistic target of rapamycin; IRS: insulin response element; PI3K: phosphoinositide-3-kinase.