fig2

Figure 2. SAM long-range interactions. BET: betaine; BHMT: betaine homocysteine methyltransferase; CHOL: choline; dMGN: dimethylglycine; HCY: homocysteine; MATI/III: methionine adenosyltransferase I/III; MATII: methionine adenosyltransferase II; dMGN: di-methylglycine; GN: glycine; GNMT: glycine methyltransferase; MHMT: methyltetrahydrofolate homocysteine methyltransferase; Me-THF: 5,10-methylenetetrahydrofolate; PC: phosphatidylcholine; PE: phosphatidylethanolamine; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine; SN: sarcosine. Red arrows indicate activation; red blunt arrows indicate inhibition.