fig1

Figure 1. Methionine and folate cycles. Substrates: BET: Betaine; CHOL: choline; dMGN: di-methylglycine; dSAM: decarboxylated S-adenosylmethionine; GN: glycine; HCY: homocysteine; MeTHF: 5,10-methylenetetrahydrofolate; MHMT: methyltetrahydrofolate homocysteine methyltransferase; PC: phosphatidylcholine; PE: phosphatidylethanolamine; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine; SN: sarcosine; THF: tetrahydrofolate. Enzymes: BHMT: Betaine homocysteine methyltransferase; CBS: cystathionine beta-synthetase; GNMT: glycine methyltransferase; MATI/III: methionine adenosyltransferase I/III; MATII: methionine adenosyltransferase II; MHMT: methyltetrahydrofolate homocysteine methyltransferase; MT: methyltransferases; MTHFR: 5-methyltetrahydrofolate reductase; ODC: ornithine decarbosylase; PEMT: phosphoethanolamine methyltransferase; SAHH: S-adenosylhomocyteine hydroxylase; SNDH: sarcosine dehydrogenase; SARDH: sarcosine dehydrogenase.