fig2

Figure 2. Involvement of UHRF1 and DNMT1 in a regenerative liver after hepatic injury. The hepatocytes of the quiescent liver do not undergo cell division. Epigenomic modulators such as DNA methylation and histone acetylation and methylation maintain the integrity of repressed and active genes. Upon liver injury, the hepatocytes synchronously re-enter the cell cycle and proliferate, where UHRF1 and DNMT1 work in coordination to maintain the methylation integrity. These regulators display the same temporal patterns as genes that control hepatocyte proliferation. Both are crucial in the DNA methylation machinery.