REFERENCES
1. Sepanlou SG, Safiri S, Bisignano C, et al. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 2020;5:245-66.
2. Global burden of liver disease: a true burden on health sciences and economies!! World Gastroenterology Organisation. Available from: https://www.worldgastroenterology.org/publications/e-wgn/e-wgn-expert-point-of-view-articles-collection/global-burden-of-liver-disease-a-true-burden-on-health-sciences-and-economies.[Last accessed on 2 Oct 2020].
3. Ueno S, Sakoda M, Kubo F, et al; Kagoshima Liver Cancer Study Group. Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria. J Hepatobiliary Pancreat Surg 2009;16:359-66.
4. Kholodenko IV, Yarygin KN. Cellular mechanisms of liver regeneration and cell-based therapies of liver diseases. Biomed Res Int 2017;2017:8910821.
6. Court FG, Wemyss-Holden SA, Dennison AR, Maddern GJ. The mystery of liver regeneration. Br J Surg 2002;89:1089-95.
7. Ozaki M. Cellular and molecular mechanisms of liver regeneration: proliferation, growth, death and protection of hepatocytes. Semin Cell Dev Biol 2020;100:62-73.
8. Preziosi ME, Monga SP. Update on the Mechanisms of Liver Regeneration. Semin Liver Dis 2017;37:141-51.
9. Huang J, Rudnick DA. Elucidating the metabolic regulation of liver regeneration. Am J Pathol 2014;184:309-21.
10. Hu H, Gehart H, Artegiani B, et al. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell 2018;175:1591-1606.e19.
11. Huch M, Gehart H, van Boxtel R, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 2015;160:299-312.
13. Forbes SJ, Newsome PN. Liver regeneration - mechanisms and models to clinical application. Nat Rev Gastroenterol Hepatol 2016;13:473-85.
14. Santoni-Rugiu E, Jelnes P, Thorgeirsson SS, Bisgaard HC. Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion. APMIS 2005;113:876-902.
15. Lu WY, Bird TG, Boulter L, et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol 2015;17:971-83.
16. Yanger K, Knigin D, Zong Y, et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell 2014;15:340-9.
17. Experimental pathology of liver: restoration of liver in white rat following partial surgical removal. ScienceOpen. Available from: https://www.scienceopen.com/document?vid=57858414-5eff-4c8d-a028-ccb3fc1c44a6. [Last accessed on 30 Sep 2020].
18. Sakamoto T, Ezure T, Lunz J, et al. Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells for parallel expansion during liver regeneration after partial hepatectomy in mice. Hepatology 2000;32:256-67.
19. Ku Y, Tominaga M, Sugimoto T, et al. Preoperative hepatic venous embolization for partial hepatectomy combined with segmental resection of major hepatic vein. Br J Surg 2002;89:63-9.
20. Kahn D, Hickman R, Terblanche J. A porcine model for the study of liver regeneration. J Invest Surg 1988;1:139-42.
21. Kahn D, Hickman R, Terblanche J, von Sommoggy S. Partial hepatectomy and liver regeneration in pigs—The response to different resection sizes. J Surg Res 1988;45:176-80.
22. Gaglio PJ, Liu H, Dash S, et al. Liver regeneration investigated in a non-human primate model (Macaca mulatta). J Hepatol 2002;37:625-32.
23. Rozga J, Jeppsson B, Bengmark S. Portal branch ligation in the rat. Reevaluation of a model. Am J Pathol 1986;125:300-308.
24. Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol 2002;283:G1074-81.
25. Ueno S, Aikou T, Tanabe G, et al. Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs. Cancer Chemother Pharmacol 1996;38:233-7.
26. Krupski G, Bröring DC, Wittkugel O, et al. Portale Kollateralenbildung nach Pfortaderligatur zur Leberregenerations-Induktion im Schweine-Modell [Formation of portal venous collaterals after ligation of the portal vein for induction of liver regeneration]. Rofo 2002;174:1281-4.
27. Nishida M, Yano K, Murakami T, Suzuki T. Introduction of monoclonal antibodies to bromodeoxyuridine to monitor hepatic regeneration. Gastroenterology 1991;100:1135-7.
28. The effect of age on regeneration of rat liver. Cancer Research. Available at: https://cancerres.aacrjournals.org/content/10/5/324. [Accessed September 30, 2020].
29. Mitchell C, Willenbring H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat Protoc 2008;3:1167-70.
30. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003;302:255-9.
31. Diehl AM. Nutrition, hormones, metabolism, and liver regeneration. Semin Liver Dis 1991;11:315-20.
32. Yan M, Huo Y, Yin S, Hu H. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biol 2018;17:274-83.
33. Das P, Chopra P, Nayak N. Hepatocellular tolerance to carbon tetrachloride induced injury in the rat: A study of its nature and possible mode of evolution. Exp Mol Pathol 1974;21:218-36.
34. Wong FW, Chan WY, Lee SS. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 1998;153:109-18.
35. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003;33:105-36.
36. Dashti H, Jeppsson B, Hägerstrand I, et al. Thioacetamide- and carbon tetrachloride-induced liver cirrhosis. Eur Surg Res 1989;21:83-91.
37. Chieli E, Malvaldi G. Role of the microsomal fad-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. Toxicology 1984;31:41-52.
38. Mangipudy RS, Chanda S, Mehendale HM. Hepatocellular regeneration: key to thioacetamide autoprotection. Pharmacol Toxicol 1995;77:182-8.
40. Zieve L, Anderson WR, Dozeman R, Draves K, Lyftogt C. Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations. J Lab Clin Med 1985;105:619-624.
41. Tuñón MJ, Alvarez M, Culebras JM, González-Gallego J. An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol 2009;15:3086-98.
42. Kofman AV, Morgan G, Kirschenbaum A, et al. Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. Hepatology 2005;41:1252-61.
43. El-Mofty SK, Scrutton MC, Serroni A, Nicolini C, Farber JL. Early, reversible plasma membrane injury in galactosamine-induced liver cell death. Am J Pathol 1975;79:579-96.
44. Macdonald JR, Thayer KJ, White C. Inhibition of galactosamine cytotoxicity in an in vivo/in vitro hepatocellular toxicity model. Toxicol Appl Pharmacol 1987;89:269-77.
45. Dabeva MD, Shafritz DA. Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am J Pathol 1993;143:1606-20.
46. Lemire JM, et al. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am J Pathol 1991;139:535-52.
47. Frank WO, et al. Effect of acute ethanol administration upon hepatic regeneration. J Lab Clin Med 1979;93:402-13.
48. Morales-González JA, Gutiérrez-Salinas J, Yáñez L, Villagómez-Rico C, Badillo-Romero J, Hernández-Muñoz R. Morphological and biochemical effects of a low ethanol dose on rat liver regeneration: role of route and timing of administration. Dig Dis Sci 1999;44:1963-74.
49. Akerman PA, Cote PM, Yang SQ, et al. Long-term ethanol consumption alters the hepatic response to the regenerative effects of tumor necrosis factor-alpha. Hepatology 1993;17:1066-73.
50. Preisegger KH, Factor VM, Fuchsbichler A, Stumptner C, Denk H, Thorgeirsson SS. Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. Lab Invest 1999;79:103-9.
51. Williams MJ, Clouston AD, Forbes SJ. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology 2014;146:349-56.
52. Passman AM, Strauss RP, McSpadden SB, et al. A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice. Dis Model Mech 2015;8:1635-41.
53. Boulter L, Govaere O, Bird TG, et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med 2012;18:572-9.
54. Tsuchiya A, Lu WY, Weinhold B, et al. Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury. Hepatology 2014;60:1727-40.
55. Goessling W. Liver Regeneration in Zebrafish. Liver Regeneration. Elsevier; 2015. pp. 41-7.
56. Curado S, Stainier DY, Anderson RM. Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studies. Nat Protoc 2008;3:948-54.
57. Kaur S, Siddiqui H, Bhat MH. Hepatic progenitor cells in action: liver regeneration or fibrosis? Am J Pathol 2015;185:2342-50.
58. Lukacs-Kornek V, Lammert F. The progenitor cell dilemma: cellular and functional heterogeneity in assistance or escalation of liver injury. J Hepatol 2017;66:619-30.
59. Greenbaum LE, Wells RG. The role of stem cells in liver repair and fibrosis. Int J Biochem Cell Biol 2011;43:222-9.
60. Libbrecht L. Hepatic progenitor cells in human liver tumor development. World J Gastroenterol 2006;12:6261-5.
62. Batusic DS, Cimica V, Chen Y, et al. Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model. Histochem Cell Biol 2005;124:245-60.
63. Cimica V, Batusic D, Chen Y, Hollemann T, Pieler T, Ramadori G. Transcriptome analysis of rat liver regeneration in a model of oval hepatic stem cells. Genomics 2005;86:352-64.
64. Sánchez A, Factor VM, Schroeder IS, Nagy P, Thorgeirsson SS. Activation of NF-kappaB and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Hepatology 2004;39:376-85.
65. Lowes KN, Croager EJ, Olynyk JK, Abraham LJ, Yeoh GC. Oval cell-mediated liver regeneration: Role of cytokines and growth factors. J Gastroenterol Hepatol 2003;18:4-12.
66. Chen J, Chen L, Zern MA, et al. The diversity and plasticity of adult hepatic progenitor cells and their niche. Liver Int 2017;37:1260-71.
67. Miyajima A, Tanaka M, Itoh T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell 2014;14:561-74.
68. Van Haele M, Roskams T. Hepatic Progenitor Cells: An Update. Gastroenterol Clin North Am 2017;46:409-20.
69. Vestentoft PS. Development and molecular composition of the hepatic progenitor cell niche. Dan Med J 2013;60:B4640.
70. Schaub JR, Malato Y, Gormond C, Willenbring H. Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury. Cell Rep 2014;8:933-9.
71. Tarlow BD, Finegold MJ, Grompe M. Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury. Hepatology 2014;60:278-89.
72. Sekiya S, Suzuki A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am J Pathol 2014;184:1468-78.
73. Nagy P, Teramoto T, Factor VM, et al. Reconstitution of liver mass via cellular hypertrophy in the rat. Hepatology 2001;33:339-45.
74. Fujiyoshi M, Ozaki M. Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases. J Hepatobiliary Pancreat Sci 2011;18:13-22.
76. Pahlavan PS, Feldmann RE Jr, Zavos C, Kountouras J. Prometheus’ challenge: molecular, cellular and systemic aspects of liver regeneration. J Surg Res 2006;134:238-51.
79. Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010;176:2-13.
81. Batusic DS, von Bargen A, Blaschke S, Dudas J, Ramadori G. Different physiology of interferon-α/-γ in models of liver regeneration in the rat. Histochem Cell Biol 2011;136:131-44.
82. Hoffmann K, Nagel AJ, Tanabe K, et al. Markers of liver regeneration-the role of growth factors and cytokines: a systematic review. BMC Surg 2020;20:31.
83. Michalopoulos GK. Hepatostat: liver regeneration and normal liver tissue maintenance. Hepatology 2017;65:1384-92.
84. Arechederra M, Berasain C, Avila MA, Fernández-Barrena MG. Chromatin dynamics during liver regeneration. Semin Cell Dev Biol 2020;97:38-46.
85. Moran-Salvador E, Mann J. Epigenetics and Liver Fibrosis. Cell Mol Gastroenterol Hepatol 2017;4:125-34.
86. Monga SP, Sadler KC. An epigenetic perspective on liver regeneration. Epigenomics 2020;12:381-4.
87. Weymann A, Hartman E, Gazit V, et al. p21 is required for dextrose-mediated inhibition of mouse liver regeneration. Hepatology 2009;50:207-15.
88. Gazit V, Weymann A, Hartman E, et al. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology 2010;52:2109-17.
89. Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology 2004;40:1322-32.
90. Holeček M. Nutritional modulation of liver regeneration by carbohydrates, lipids, and amino acids: a review. Nutrition 1999;15:784-8.
91. Srinivasan SR, Chow CK, Glauert HP. Effect of the peroxisome proliferator ciprofibrate on hepatic DNA synthesis and hepatic composition following partial hepatectomy in rats. Toxicology 1990;62:321-32.
92. Walldorf J, Hillebrand C, Aurich H, et al. Propranolol impairs liver regeneration after partial hepatectomy in C57Bl/6-mice by transient attenuation of hepatic lipid accumulation and increased apoptosis. Scand J Gastroenterol 2010;45:468-76.
93. Chen L, Zeng Y, Yang H, et al. Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J 2004;18:914-6.
94. Brebnor LD, Balinsky JB. Changes in activities of urea cycle enzymes in early stages of liver regeneration after partial hepatectomy in rats. Life Sci 1983;32:1391-400.
95. Gebhardt R. Altered acinar distribution of glutamine synthetase and different growth response of cultured enzyme-positive and -negative hepatocytes after partial hepatectomy. Cancer Res 1990;50:4407-10.
96. Freeman TL, Ngo HQ, Mailliard ME. Inhibition of system A amino acid transport and hepatocyte proliferation following partial hepatectomy in the rat. Hepatology 1999;30:437-44.
97. Holecek M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition 2010;26:482-90.
98. Hall AP, Elcombe CR, Foster JR, et al. Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop. Toxicol Pathol 2012;40:971-94.
99. Lee SS, Pineau T, Drago J, et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 1995;15:3012-22.
100. Chakravarthy MV, Lodhi IJ, Yin L, et al. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 2009;138:476-88.
101. Bhushan B, Michalopoulos GK. Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor. Chem Biol Interact 2020;324:109090.
102. López-Luque J, Caballero-Díaz D, Martinez-Palacián A, et al. Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis. Hepatology 2016;63:604-19.
103. Bhushan B, Banerjee S, Paranjpe S, et al. Pharmacologic inhibition of epidermal growth factor receptor suppresses nonalcoholic fatty liver disease in a murine fast-food diet model. Hepatology 2019;70:1546-63.
104. Obata T, Maegawa H, Kashiwagi A, Pillay TS, Kikkawa R. High glucose-induced abnormal epidermal growth factor signaling. J Biochem 1998;123:813-20.
105. Blackshear PJ, Stumpo DJ, Kennington EA, et al. Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents. J Biol Chem 1987;262:12356-64.
106. Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A 2002;99:11181-6.
107. Kelley-Loughnane N, Sabla GE, Ley-Ebert C, Aronow BJ, Bezerra JA. Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology 2002;35:525-34.
108. White P, Brestelli JE, Kaestner KH, Greenbaum LE. Identification of transcriptional networks during liver regeneration. J Biol Chem 2005;280:3715-22.
109. Li J, Campbell JS, Mitchell C, et al. Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice. Am J Pathol 2009;175:947-57.
110. Yi P, Zhang M, Xu M. Role of microRNA in liver regeneration. Hepatobiliary Pancreat Dis Int 2016;15:141-6.
111. Lauschke VM, Mkrtchian S, Ingelman-Sundberg M. The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration. Biochem Biophys Res Commun 2017;482:399-407.
112. Chen X, Zhao Y, Wang F, Bei Y, Xiao J, Yang C. MicroRNAs in Liver Regeneration. Cell Physiol Biochem 2015;37:615-28.
113. Sun X, Chuang JC, Kanchwala M, et al. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 2016;18:456-66.
114. Sinha S, Verma S, Chaturvedi MM. Differential expression of SWI/SNF chromatin remodeler subunits Brahma and Brahma-Related gene during drug-induced liver injury and regeneration in mouse model. DNA Cell Biol 2016;35:373-84.
115. Wang S, Zhang C, Hasson D, et al. Epigenetic compensation promotes liver regeneration. Dev Cell 2019;50:43-56.e6.
116. Russell JO, Ko S, Saggi HS, et al. Bromodomain and extraterminal (BET) proteins regulate hepatocyte proliferation in hepatocyte-driven liver regeneration. Am J Pathol 2018;188:1389-405.
117. Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest 2010;120:4316-31.
118. Fang S, Tsang S, Jones R, et al. The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem 2008;283:35086-95.
119. Breaux M, Lewis K, Valanejad L, et al. p300 regulates liver functions by controlling p53 and C/EBP family proteins through multiple signaling pathways. Mol Cell Biol 2015;35:3005-16.
120. Huang J, Schriefer AE, Yang W, Cliften PF, Rudnick DA. Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition. Epigenetics 2014;9:1521-31.
121. Bae WK, Kang K, Yu JH, et al. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. FASEB J 2015;29:1653-62.
122. Loforese G, Malinka T, Keogh A, et al. Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2. EMBO Mol Med 2017;9:46-60.
123. Lu L, Finegold MJ, Johnson RL. Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration. Exp Mol Med 2018;50:e423.
124. Grijalva JL, Huizenga M, Mueller K, et al. Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. Am J Physiol Gastrointest Liver Physiol 2014;307:G196-204.
125. Bai H, Zhang N, Xu Y, et al. Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology 2012;56:1097-107.
126. Moya IM, Halder G. Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine. Nat Rev Mol Cell Biol 2019;20:211-26.
127. Wang HY, Long QY, Tang SB, et al. Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. Nucleic Acids Res 2019;47:2349-64.
128. Liu X, Li C, Zhang R, et al. The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells. Cell Signal 2018;51:243-56.
129. Aloia L, McKie MA, Vernaz G, et al. Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Nat Cell Biol 2019;21:1321-33.
130. Etchegaray JP, Mostoslavsky R. Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes. Mol Cell 2016;62:695-711.
132. Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature 2013;502:489-98.
133. Fan J, Krautkramer KA, Feldman JL, Denu JM. Metabolic regulation of histone post-translational modifications. ACS Chem Biol 2015;10:95-108.
134. Tzika E, Dreker T, Imhof A. Epigenetics and metabolism in health and disease. Front Genet 2018;9:361.
135. Mato JM, Lu SC. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 2007;45:1306-12.
136. Cihák A, Seifertová M, Veselý J, Sorm F. Metabolic alterations of liver regeneration. 8. Enhanced synthesis of DNA in the liver of 5-azacytidine-treated rats subjected to partial hepatectomy. Int J Cancer 1972;10:20-7.
138. Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011;333:1300-3.
139. Huang J, Barr E, Rudnick DA. Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology 2013;57:1742-51.
140. Mihaylova MM, Vasquez DS, Ravnskjaer K, et al. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 2011;145:607-21.
141. Shimazu T, Hirschey MD, Newman J, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 2013;339:211-4.
