REFERENCES
1. Akinyemiju T, Abera S, Ahmed M, Alam N, Alemayohu MA, et al; Global Burden of Disease Liver Cancer Collaboration. The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015. JAMA Oncol 2017;3:1683-91.
2. WHO. Global status report on alcohol and health 2018. Available from: http://www.who.int/substance_abuse/publications/global_alcohol_report/gsr_2018/en/ [Last accesed on 18 Feb 2020].
3. Thursz M, Gual A, Lackner C, Mathurin P, Moreno C, et al. EASL clinical practice guidelines: management of alcohol-related liver disease. J Hepatol 2018;69:154-81.
4. Teschke R, Zhu Y. “Opinion: intestinal microbiome, endotoxins, cytochrome P450 2E1, and the gut-liver axis in alcoholic liver disease”. EC Gastroenterol Dig Syst 2019:66-75.
5. Teschke R. Alcoholic liver disease: current mechanistic aspects with focus on their clinical relevance. Biomedicines 2019;7.
6. Méndez-Sánchez N, Villa AR, Chávez-Tapia NC, Ponciano-Rodriguez G, Almeda-Valdés P, et al. Trends in liver disease prevalence in Mexico from 2005 to 2050 through mortality data. Ann Hepatol 2005;4:52-5.
7. Teschke R. Hepatocellular carcinoma in alcoholic liver disease: mechanistic considerations and clinical facts. Hepatoma Res 2019;5:40.
8. Motola-Kuba D, Zamora-Valdés D, Uribe M, Méndez-Sánchez N. Hepatocellular carcinoma. An overview. Ann Hepatol 2006;5:16-24.
9. Méndez-Sánchez N, Zamarripa-Dorsey F, Panduro A, Purón-González E, Coronado-Alejandro EU, et al. Current trends of liver cirrhosis in Mexico: similitudes and differences with other world regions. World J Clin Cases 2018;6:922-30.
10. Seitz HK, Gärtner U, Egerer G, Simanowski UA. Ethanol metabolism in the gastrointestinal tract and its possible consequences. Alcohol Alcohol Suppl 1994;2:157-62.
11. Ganne-Carrié N, Nahon P. Hepatocellular carcinoma in the setting of alcohol-related liver disease. J Hepatol 2019;70:284-93.
12. Zhong Z, Lemasters JJ. A unifying hypothesis linking hepatic adaptations for ethanol metabolism to the proinflammatory and profibrotic events of alcoholic liver disease. Alcohol Clin Exp Re 2018;42:2072-89.
13. Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001;1:515-25.
14. Palma E, Riva A, Moreno C, Odena G, Mudan S, et al. Perturbations in mitochondrial dynamics are closely involved in the progression of alcoholic liver disease. Alcohol Clin Exp Res 2020. Epub ahead of print [PMID: 32020641 DOI: 10.1111/acer.14299]
15. Seitz HK, Korsten MA, Lieber CS. Ethanol oxidation by intestinal microsomes: increased activity after chronic ethanol administration. Life Sci 1979;25:1443-8.
16. Pronko P, Bardina L, Satanovskaya V, Kuzmich A, Zimatkin S. Effect of chronic alcohol consumption on the ethanol- and acetaldehyde-metabolizing systems in the rat gastrointestinal tract. Alcohol Alcohol 2002;37:229-35.
17. Teschke R. Review article. Biochemical aspects of the hepatic microsomal ethanol-oxidizing system (MEOS): resolved initial controversies and updated molecular views. Biochem Pharmacol (Los Angel) 2019;8:267.
18. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature 2012;489:220-30.
19. Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 2016;164:337-40.
20. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010;464:59-65.
21. Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 2013;24:1415-22.
22. Stärkel P, Leclercq S, de Timary P, Schnabl B. Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease. Clin Sci 2018;132:199-212.
23. Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol 2009;124:3-20. quiz 21-2
24. Kim YS, Ho SB. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 2010;12:319-30.
25. Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci 2019;76:473-93.
26. Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, Lu SC. Alcohol, DNA methylation, and cancer. Alcohol Res 2013;35:25-35.
27. Fabris C, Toniutto P, Falleti E, Fontanini E, Cussigh A, et al. MTHFR C677T polymorphism and risk of hcc in patients with liver cirrhosis: role of male gender and alcohol consumption. Alcohol Clin Exp Res 2009;33:102-7.
28. Saffroy R, Pham P, Chiappini F, Gross-Goupil M, Castera L, et al. The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis. Carcinogenesis 2004;25:1443-8.
29. Lu SC, Mato JM. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol 2005;35:227-34.
30. Teschke R. Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects. Biomedicines 2018;6.
31. Hu W, Feng Z, Eveleigh J, Iyer G, Pan J, et al. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 2002;23:1781-9.
32. Wang Y, Tong J, Chang B, Wang B, Zhang D, et al. Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins. Mol Med Rep 2014;9:2352-6.
33. Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, et al. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PLoS One 2013;8:e53028.
34. Wang Y, Kirpich I, Liu Y, Ma Z, Barve S, et al. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol 2011;179:2866-75.
35. Bajaj JS, Kakiyama G, Zhao D, Takei H, Fagan A, et al. Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis. Alcohol Clin Exp Res 2017;41:1857-65.
36. Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014;60:940-7.
37. Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, et al. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 2012;302:G966-78.
38. Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, et al. Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation. Cell Host Microbe 2016;19:227-39.
39. Chen P, Stärkel P, Turner JR, Ho SB, Schnabl B. Dysbiosis-induced intestinal inflammation activates TNFRI and mediates alcoholic liver disease in mice. Hepatology 2015;61:883-94.
40. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009;58:1091-103.
41. Bode C, Kugler V, Bode JC. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 1987;4:8-14.
42. Fukui H, Brauner B, Bode JCh, Bode Ch. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J Hepatol 1991;12:162-9.
43. Duque Correa MA, Rojas López M. Activación alternativa del macrófago: La diversidad en las respuestas de una célula de la inmunidad innata ante la complejidad de los eventos de su ambiente. Inmunologia 2007;26:73-86. (in Spanish)
44. Leclercq S, Cani PD, Neyrinck AM, Stärkel P, Jamar F, et al. Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain Behav Immun 2012;26:911-8.
45. Grabherr F, Grander C, Adolph TE, Wieser V, Mayr L, et al. Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease. Liver Int 2018;38:1095-101.
46. Zhao JJ, Pan QZ, Pan K, Weng DS, Wang QJ, et al. Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells. Sci Rep 2015;4:5177.
47. Yu LX, Schwabe RF. The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol 2017;14:527-39.
48. Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012;21:504-16.
49. Toyoda H, Komurasaki T, Uchida D, Takayama Y, Isobe T, et al. Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J Biol Chem 1995;270:7495-500.
50. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001;34:101-8.
51. Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995;108:218-24.
52. Yan G, Wang X, Sun C, Zheng X, Wei H, et al. Chronic alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis via immune disturbances. Sci Rep 2017;7:2567.
53. Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013;499:97-101.
54. Xie G, Wang X, Liu P, Wei R, Chen W, et al. Distinctly altered gut microbiota in the progression of liver disease. Oncotarget 2016;7:19355-66.
55. Grąt M, Krasnodębski M, Patkowski W, Wronka KM, Masior Ł, et al. Relevance of pre-transplant α-fetoprotein dynamics in liver transplantation for hepatocellular cancer. Ann Transplant 2016;21:115-24.
56. Ren Z, Li A, Jiang J, Zhou L, Yu Z, et al. Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma. Gut 2019;68:1014-23.
57. Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA. The microbiome, cancer, and cancer therapy. Nat Med 2019;25:377-88.
58. Fox JG, Feng Y, Theve EJ, Raczynski AR, Fiala JLA, et al. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 2010;59:88-97.
59. Rogers AB. Distance burning: how gut microbes promote extraintestinal cancers. Gut Microbes 2011;2:52-7.
60. Huang Y, Fan XG, Wang ZM, Zhou JH, Tian XF, et al. Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J Clin Pathol 2004;57:1273-7.
61. Temko JE, Bouhlal S, Farokhnia M, Lee MR, Cryan JF, et al. The microbiota, the gut and the brain in eating and alcohol use disorders: a “ménage à trois”? Alcohol Alcohol 2017;52:403-13.
62. Bishehsari F, Magno E, Swanson G, Desai V, Voigt RM, et al. Alcohol and gut-derived inflammation. Alcohol Res 2017;38:163-71.
63. Ling Z, Liu X, Cheng Y, Jiang X, Jiang H, et al. Decreased diversity of the oral microbiota of patients with hepatitis b virus-induced chronic liver disease: a pilot project. Sci Rep 2015;5:17098.
64. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76.
65. Bajaj JS, Sterling RK, Betrapally NS, Nixon DE, Fuchs M, et al. HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients. Aliment Pharmacol Ther 2016;44:638-43.
66. Maggio R, Viscomi C, Andreozzi P, D’Ettorre G, Viscogliosi G, et al. Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection. PLoS One 2014;9:e112346.
67. Preveden T, Scarpellini E, Milić N, Luzza F, Abenavoli L. Gut microbiota changes and chronic hepatitis C virus infection. Expert Rev Gastroenterol Hepatol 2017;11:813-9.
68. Aly AM, Adel A, El-Gendy AO, Essam TM, Aziz RK. Gut microbiome alterations in patients with stage 4 hepatitis C. Gut Pathog 2016;8:42.
69. Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2013;2:e01202.
70. Sousa GM, Oliveira IS, Andrade LJO, Sousa-Atta MLB, Paraná R, et al. Serum levels of Th17 associated cytokines in chronic hepatitis C virus infection. Cytokine 2012;60:138-42.
71. Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap--bile acids in metabolic control. Nat Rev Endocrinol 2014;10:488-98.
72. Jia W, Xie G, Jia W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol 2018;15:111-28.
73. Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006;290:G1124-30.
74. Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001;276:28857-65.
76. Jung IH, Choi JHK, Chung YY, Lim GL, Park YN, et al. Predominant activation of JAK/STAT3 pathway by interleukin-6 is implicated in hepatocarcinogenesis. Neoplasia 2015;17:586-97.
77. Nag S, Qin J, Srivenugopal KS, Wang M, Zhang R. The MDM2-p53 pathway revisited. J Biomed Res 2013;27:254-71.
78. Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010;10:51-7.
79. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008;6:2853-68.
80. Nishida S, Hamada K, Nishino N, Fukushima D, Koyanagi R, et al. Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese. World J Hepatol 2019;11:531-41.
81. Kang SH, Lee YB, Lee JH, Nam JY, Chang Y, et al. Rifaximin treatment is associated with reduced risk of cirrhotic complications and prolonged overall survival in patients experiencing hepatic encephalopathy. Aliment Pharmacol Ther 2017;46:845-55.
82. Elfert A, Abo Ali L, Soliman S, Ibrahim S, Abd-Elsalam S. Randomized-controlled trial of rifaximin versus norfloxacin for secondary prophylaxis of spontaneous bacterial peritonitis. Eur J Gastroenterol Hepatol 2016;28:1450-4.
83. Kalambokis GN, Mouzaki A, Rodi M, Pappas K, Fotopoulos A, et al. Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites. Clin Gastroenterol Hepatol 2012;10:815-8.
84. Vlachogiannakos J, Viazis N, Vasianopoulou P, Vafiadis I, Karamanolis DG, et al. Long-term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis: rifaximin improves prognosis in cirrhosis. J Gastroenterol Hepatol 2013;28:450-5.
85. Shariff MIF, Tognarelli JM, Lewis MR, Want EJ, Mohamed FEZ, et al. Plasma lipid profiling in a rat model of hepatocellular carcinoma: potential modulation through quinolone administration. J Clin Exp Hepatol 2015;5:286-94.
86. Ginés P, Rimola A, Planas R, Vargas V, Marco F, et al. Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double-blind, placebo-controlled trial. Hepatology 1990;12:716-24.
87. Fernández J, Navasa M, Gómez J, Colmenero J, Vila J, et al. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology 2002;35:140-8.
88. Li J, Sung CYJ, Lee N, Ni Y, Pihlajamäki J, et al. Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. Proc Natl Acad Sci U S A 2016;113:E1306-15.
