REFERENCES
1. Alazawi W, Cunningham M, Dearden J, Foster GR. Systematic review: outcome of compensated cirrhosis due to chronic hepatitis C infection. Aliment Pharmacol Ther 2010;32:344-55.
2. Fattovich G, Pantalena M, Zagni I, Realdi G, Schalm SW, et al. Effect of hepatitis B and C virus infections on the natural history of compensated cirrhosis: a cohort study of 297 patients. Am J Gastroenterol 2002;97:2886-95.
3. Kobayashi M, Ikeda K, Hosaka T, Sezaki H, Someya T, et al. Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections. J Med Virol 2006;78:459-65.
4. Toshikuni N, Izumi A, Nishino K, Inada N, Sakanoue R, et al. Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus-related cirrhosis. J Gastroenterol Hepatol 2009;24:1276-83.
5. Wirth TC, Manns MP. The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma. Ann Oncol 2016;27:1467-74.
6. Gaddikeri S, McNeeley MF, Wang CL, Bhargava P, Dighe MK, et al. Hepatocellular Carcinoma in the Noncirrhotic Liver. Am J Roentgenol 2014;203:34-47.
7. El-Refaie A, Savage K, Bhattacharya S, Khakoo S, Harrison TJ, et al. HCV-associated hepatocellular carcinoma without cirrhosis. J Hepatol 1996;24:277-85.
8. Yeh M, Daniel H, Torbenson M. Hepatitis c associated hepatocellular carcinomas in non- cirrhotic livers. Mod Pathol 2010;23:276-83.
9. Ray RB, Meyer K, Ray R. Hepatitic decompensation is the major driver of death in HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma. Virology 2000;271:197-204.
11. McCombs J, Matsuda T, Tonnu-Mihara I, Saab S, Hines P, et al. The risk of long-term morbidity and mortality in patients with chronic hepatitis c : results from an analysis of data from a department of veterans affairs clinical registry. JAMA Intern Med 2014;174:204-12.
12. van der Meer AJ, Veldt BJ, Feld JJ, Wedemeyer H, Dufour JF, et al. Association between sustained virological response and all cause mortality among patients with chronic hepatitis c and advanced hepatic fibrosis. J Am Med Assoc 2012;308:2584-93.
13. Cabibbo G, Petta S, Barbara M, Attardo S, Bucci L, et al. Hepatic decompensation is the major driver of death in hcv-infected cirrhotic patients with successfully treated early hepatocellular carcinoma. J Hepatol 2017;67:65-71.
15. McHutchison JG, et al. Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C. N Engl J Med 1998;339:1485-92.
16. Manns M P, Wedemeyer H, Cornberg M. Treating viral hepatitis C: efficacy, side effects, and complications. Gut 2006;55:1350-9.
17. Hsu CS, Chao YC, Lin HH, Chen DS, Kao JH. Systematic review: impact of interferon-based therapy on hcv-related hepatocellular carcinoma. Sci Rep 2015;5:1-9.
18. Kohli A, Shaffer A, Sherman A, Kottilil S. Treatment of hepatitis C: a systematic review. J Am Med Assoc 2014;312:631-40.
19. Geddawy A, Ibrahim YF, Elbahie NM, Ibrahim MA. Direct acting anti-hepatitis C virus drugs: Clinical pharmacology and future direction. J Transl Intern Med 2017;5:8-17.
20. Putra J, Schiano T, Fiel MI. Histological assessment of the liver explant in transplanted hcv-patients achieving sustained virologic response with direct-acting antiviral agents. Histopathology 2018;72:990-6.
21. Ahmad J, Eng F, Branch AD. HCV and HCC : clinical update and a review of hcc-associated viral mutations in the core gene. Semin. Liver Dis 2011;31:347-55.
22. Lok AS, Seeff LB, Morgan TR, di Bisceglie AM, Sterling RK, et al. Incidence of hepatocellular carcinoma and associated risk factors in hepatitis c-related advanced liver disease. Gastroenterology 2009;136:138-48.
23. Lok AS, Everhart JE, Wright EC, Di Bisceglie AM, Kim HYt, et al. Maintenance peginterferon therapy and other factors associated with hepatocellular carcinoma in patients with advanced hepatitis c. Gastroenterology 2011;140:840-9.
24. Shiffman ML, Morishima C, Dienstag JL, Lindsay KL, Hoefs JC, et al. Effect of HCV RNA suppression during peginterferon alfa-2a maintenance therapy on clinical outcomes in the HALT-C trial. Gastroenterology 2009;137:1986-94.
25. Morgan TR, Ghany MG, Kim HY, Snow KK, Shiffman ML, et al. Outcome of sustained virological responders with histologically advanced chronic hepatitis c. Hepatology 2010;52:833-44.
26. Cardoso AC, Moucari R, Figueiredo-Mendes C, Ripault MP, Giuily N, et al. Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis. J Hepatol 2010;52:652-7.
27. Kusano H, Akiba J, Ogasawara S, Sanada S, Yasumoto M, et al. Pegylated interferon-α2a inhibits proliferation of human liver cancer cells in vitro and in vivo. PLoS One 2013;8:1-10.
28. Llovet JM, Fuster J, Bruix J. The barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transplant 2004;10:115-20.
29. Zhang YJ, Liu YT, Yu XS. Effect of interferon therapy on outcomes after hepatic resection for hepatitis C virus-related hepatocellular carcinoma: a meta-analysis. Int J Clin Exp Med 2016;9:1675-83.
30. Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, et al. Impact of pegylated interferon therapy on outcomes of patients with hepatitis c virus-related hepatocellular carcinoma after curative hepatic resection. Ann Surg Oncol 2012;19:418-25.
31. Singal AK, Freeman DH Jr, Anand BS. Meta-analysis: interferon improves outcomes following ablation or resection of hepatocellular carcinoma. Aliment Pharmacol Ther 2010;32:851-8.
32. Miao RY, Zhao HT, Yang HY, Mao YL, Lu X, et al. Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: a meta-analysis. World J. Gastroenterol 2010;16:2931-42.
33. Kushner T, Dieterich D, Saberi B. Direct-acting antiviral treatment for patients with hepatocellular carcinoma. Curr Opin Gastroenterol 2018;34:1-8.
34. Prenner SB, Kulik L. Hepatocellular carcinoma in the wait-listed patient with hepatitis C virus. Curr Opin Organ Transplant 2018;23:237-43.
35. Saberi B, Dadabhai AS, Durand CM, Philosophe B, Cameron AM, et al. Challenges in treatment of hepatitis c among patients with hepatocellular carcinoma. Hepatology 2017;66:661-3.
36. Beste LA, Green PK, Berry K, Kogut MJ, Allison SK, et al. Effectiveness of hepatitis c antiviral treatment in a USA cohort of veteran patients with hepatocellular carcinoma. J Hepatol 2017;67:32-9.
37. Prenner SB, VanWagner LB, Flamm SL, Salem R, Lewandowski RJ, et al. Hepatocellular carcinoma decreases the chance of successful hepatitis C virus therapy with direct-acting antivirals. J Hepatol 2017;66:1173-81.
38. Radhakrishnan K, Di Bisceglie Adrian M., Reddy K. Rajender, Lim Joseph K., Levitsky Josh, et al. Impact of hepatocellular carcinoma (HCC) and tumor treatment on sustained virologic response (SVR) rates with direct-acting antiviral (DAA) therapy for hepatitis C: HCV-TARGET results. Hepatology 2017;66:755-6.
39. Soria A, Fabbiani M, Lapadula G, Gori A. Unexpected viral relapses in hepatitis C virus-infected patients diagnosed with hepatocellular carcinoma during treatment with direct-acting antivirals. Hepatology 2017;66:992-4.
40. Ji F, Yeo YH, Wei MT, Wei B, Dang S, et al. Hepatocellular carcinoma decreases the effectiveness of hepatitis C antiviral treatment: Do direct-acting antiviral regimens matter? Hepatology 2018;67:1180-2.
41. Reig M, Mariño Z, Perelló C, Iñarrairaegui M, Ribeiro A, et al. Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy. J Hepatol 2016;65:719-26.
42. Guarino M, Sessa A, Cossiga V, Morando F, Caporaso N, et al. Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: a few lights and many shadows. World J Gastroenterol 2018;24:2582-95.
43. El-Serag HB, Kanwal F, Richardson P, Kramer J. Risk of hepatocellular carcinoma after sustained virological response in veterans with hepatitis c virus infection. Hepatology 2016;64:130-7.
44. Waziry R, Hajarizadeh B, Grebely J, Amin J, Law M, et al. Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression. J Hepatol 2017;67:1204-12.
45. Ioannou GN, Green PK, Berry K. HCV eradication induced by direct-acting antiviral agents reduces the risk of hepatocellular carcinoma. J Hepatol 2018;68:25-32.
46. Recurrence Rate of Hepatocellular Carcinoma After Treatment of Chronic Hepatits C Patients With Direct Acting Antivirals: Randomized Controlled Phase 3 Trial. Available from: https://clinicaltrials.gov/ct2/show/NCT03551444 [Last accessed on 27 June 2019].
47. Incidence of de Novo Hepatocellular Carcinoma After Antiviral Agents for HCV. Available from: https://clinicaltrials.gov/ct2/show/NCT03551444 [Last accessed on 27 June 2019].
48. Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment (LONGHEAD). Available from: https://clinicaltrials.gov/ct2/show/NCT03551444 [Last accessed on 27 June 2019].
49. Effect of DAAs on Behavior of HCC in HCV Patients. Available from: https://clinicaltrials.gov/ct2/show/NCT03551444 [Last accessed on 27 June 2019].
50. Direct Acting Antiviral-Post Authorization Safety Study. Available from: https://clinicaltrials.gov/ct2/show/NCT03551444 [Last accessed on 27 June 2019].
52. Pascasio JM, Vinaixa C, Ferrer MT, Colmenero J, Rubin A, et al. Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation. J Hepatol 2017;67:1168-76.
53. Persico M, Aglitti A, Aghemo A, Rendina M, Lleo A, et al. High efficacy of direct-acting anti-viral agents in hepatitis C virus-infected cirrhotic patients with successfully treated hepatocellular carcinoma. Aliment Pharmacol Ther 2018;47:1705-12.
54. Hassany M, Elsharkawy A, Maged A, Mehrez M, Asem N, et al. Hepatitis C virus treatment by direct-acting antivirals in successfully treated hepatocellular carcinoma and possible mutual impact. Eur J Gastroenterol Hepatol 2018;30:876-81.
55. Bas A, Samanci C, Gulsen F, Cantasdemir M, Kabasakal L, et al. Evaluation of liver stiffness after radioembolization by real-time shearwave TM elastography : preliminary study. Cardiovasc Intervent Radiol 2014;38:957-63.
56. LLovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90.
57. Llovet JM, Ducreux M, Lencioni R, Di Bisceglie AM, Dufour JF, et al. EASL - EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2012;56:908-43.
58. Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology 2018;67:358-80.
59. Himmelsbach K, Sauter D, Baumert TF, Ludwig L, Blum HE, et al. New aspects of an anti-tumour drug: Sorafenib efficiently inhibits HCV replication. Gut 2009;58:1644-53.
60. Bürckstümmer T, Kriegs M, Lupberger J, Pauli EK, Schmittel S, et al. Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication. FEBS Lett 2006;580:575-80.
61. Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, et al. HRas signal transduction promotes hepatitis c virus cell entry by triggering assembly of the host tetraspanin receptor complex. Cell Host Microbe 2013;13:302-13.
62. Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, et al. MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles. PLoS Pathog 2012;8:1-17.
63. Descamps V, Helle F, Louandre C, Martin E, Brochot E, et al. The kinase-inhibitor sorafenib inhibits multiple steps of the Hepatitis C Virus infectious cycle in vitro. Antiviral Res 2015;118:93-102.
64. Cabrera R, Limaye AR, Horne P, Mills R, Soldevila-Pico C, et al. The antiviral effect of sorafenib in hepatitis c-related hepatocellular carcinoma. Aliment Pharmacol Ther 2013;37:91-7.
65. Ji F, Li Z. Letter : the antiviral activity of sorafenib in patients with hepatitis C-related hepatocellular carcinoma. Aliment Pharmacol Ther 2013;37:372-3.
66. Bruix J, Cheng AL, Meinhardt G, Nakajima K, De Sanctis Y, et al. Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: analysis of two phase III studies. J Hepatol 2017;67:999-1008.
67. Llovet JM, Montal R, Sia D, Finn RS. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol 2018;15:599-616.
68. Liverpool U. of. HEP Drug Interaction checker.
69. Revuelta-Herrero JL, Giménez-Manzorro A, Matilla-Peña A, Herranz-Alonso A, Sanjurjo-Sáez M. Concomitant use of sorafenib with ombitasvir/paritaprevir/ritonavir and dasabuvir: Effectiveness and safety in clinical practice. J Clin Pharm Ther 2018;43:906-9.
70. Moreno-Cubero E, Larrubia JR. Specific CD8+ T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis. World J Gastroenterol 2016;22:6469-83.
71. Gardiner D, Lalezari J, Lawitz E, DiMicco M, Ghalib R, et al. A randomized, double-blind, placebo-controlled assessment of bms-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis c virus infection. PLoS One 2013;8:1-11.
72. El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet 2017;389:2492-502.
73. Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, et al. Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib ( KEYNOTE-224 ): a non-randomised, open-label phase 2 trial. Lancet Oncol 2018;940-52.
74. Mazouz S, Boisvert M, Shoukry NH, Lamarre D. Reversing immune dysfunction and liver damage after direct-acting antiviral treatment for hepatitis C. Can Liver J 2018;1:78-105.
75. Meissner EG, Kohli A, Higgins J, Lee YJ, Prokunina O, et al. Rapid changes in peripheral lymphocyte concentrations during interferon-free treatment of chronic hepatitis c virus infection. Hepatol Commun 2017;1:586-94.
76. AASLD & IDSA. AASLD/IDSA HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. Clin Liver Dis (Hoboken) 2018;12:117.
77. Kawaoka T, Aikata H, Teraoka Y, Inagaki Y, Honda F, et al. Impact of hepatitis c virus eradication on the clinical outcome of patients with hepatitis c virus-related advanced hepatocellular carcinoma treated with sorafenib. Oncology 2017;92:335-46.
78. Curry MP, Forns X, Chung RT, Terrault NA, Brown R Jr, et al. Sofosbuvir and ribavirin prevent recurrence of hcv infection after liver transplantation: an open-label study. Gastroenterology 2015;148:100-7.
