fig1

Figure 1. Ion channel-based therapy for HCC prevention and treatment. The expression of several ion channels is altered in liver disorders leading to HCC, as well as in HCC. Because of the very relevant participation of ion channels in cellular processes leading to HCC, targeting either the expression or activity of these proteins may lead to the prevention and treatment of liver diseases including HCC. HCC: hepatocellular carcinoma; HCV: hepatitis C virus; HBV: hepatitis B virus; NAFLD: nonalcoholic fatty liver disease