fig6

Figure 6. Far upstream element-binding protein-interacting repressor Δexon2 (FIRΔexon2) inhibitor BK697 inhibited the growth of the HeLa cells. BK697 is a candidate anticancer drug for inhibiting hepatitis B virus (HBV) replication for hepatoma therapy. FIR/poly (U)-binding-splicing factor (PUF60) has three different functions. (1) A c-Myc gene transcriptional repressor; (2) disturbance of substrate proteins degradation through competing with the access to degron pocket of F-box and WD repeat domain-containing 7 (FBW7); and (3) transcriptional/posttranscriptional regulation of HBV covalently closed circular DNA (cccDNA). Targeting FIR/PUF60 is a promising strategy for cancer therapy. FIR: FUBP1-interacting repressor; WD: W (Typ) D (Asp)