fig1

Figure 1. Immunohistochemistry of Wnt3a or Wnt5a expression in HCC tissues with different staging^[20,65]. (A) The Wnt3a expression in HCC tissues (SP, original magnification: A1-A5, ×200; B1-B5, ×400); (B) the Wnt5a expression in HCC tissue (SP, original magnification, A1-A5, ×200; B1-B5, ×400). In Wnt3a, A1 and B1, the low or without Wnt3a expression in the para-cancerous tissues, and A2-A5 and B2-B5, the brown staining of Wat3a expression with gradually increasing from stage I, II to III-IV of HCC tissues; In Wnt5a, A1 and B1, the strongest Wnt3a expression in the para-cancerous tissues, and A2-A4 and B2-B4, the brown staining of Wat3a expression with gradually decreasing from stage I to III of HCC tissues, and A5 and B5, the low or without Wnt5a expression were discovered in HCC tissues at stage IV. HCC: hepatocellular carcinoma tissues; Para-HCC: paracancerous tissues; Wnt3a: wingless-type MMTV integration site family member 3a; Wnt5a: wingless-type MMTV integration site family member 5a