fig1

Figure 1. Molecular pathways involved in hypoxia HCC malignance. HCC: hepatocellular carcinoma; YAP: Yes associate-protein; MMPs: matrix metalloproteinases; HMGB1: high mobility group box 1; TLR: Toll-like receptor; IL: interleukin; VEGF: vascular endothelial growth factor; HIF: hypoxia-induced factor; SCF: stem cell factor