Topic: Natural Products and Hepatocellular Carcinoma

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A special issue of Hepatoma Research  (Print ISSN:2394-5079; Online ISSN:2454-2520).

Deadline for manuscript submissions: 10 Nov 2015

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Guest Editor(s)

  • Mosaad Attia Abdel-Wahhab, MD
    Food Toxicology and Contaminants Department, National Research Center, Dokki, Cairo 12622, Egypt.


Special Issue Introduction:

Hepatocellular carcinoma (HCC) is a major health problem, with more than 500,000 cases diagnosed annually. Natural products (NPs) are chemical compounds or substances produced by a living organism found in nature. Some NPs have beneficial effects however; some others have toxic effects. Several mycotoxins were classified as hepatocarcinogenic. The most important mycotoxins is aflatoxin B1 (AFB1) which is a mutagenic natural compound contaminate many food sources, especially in some parts of Africa and Asia and is recognized as one of the most potent hepatocarcinogens in humans. Recent research pointed out an increasing interest concerning the health benefits of a diet rich in NPs. The use of herbal medicines can be traced back several thousand years ago in ancient China, ancient Egyptian and Romans. Generally, NPs have played a key role in drug discovery and are still a prolific source of novel lead compounds or pharmacophores for medicinal chemistry. Although, HCC is always hard to treat, this special issue aims to gather updated progress in this important area and shed the light on the possibility to introduce a new drug based on the benefit of NPs.

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 10 Nov 2015
Contacts: Lijun Jin, Managing Editor,

Published Articles Download All Articles
  • Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

    Mosaad A. Abdel-Wahhab , Olivier Joubert , Aziza A. El-Nekeety , Hafiza A. Sharaf , Ferial M. Abu-Salem , Bertrand H. Rihn
    Aim: This study aimed to determine the composition of ethanol extract of jojoba seeds, and to evaluate its hepatoprotective effects in rats fed fumonisin B1 (FB1)-contaminated diet. Methods: Jojoba seeds were extracted in 95% ethanol, and the chemical composition was determined. Male rats were divided into six groups and treated for 8 weeks as follows: (1) Untreated control; (2)... Read more
    Hepatoma Res 2016;2:78-86. | doi:10.4103/2394-5079.168078
    Published on: 9 Mar 2016  | Viewed:4057  | Downloaded:241
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  • Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse effects owing to chemotherapy and recurrence. The role of Curcumin as an adjuvant remedy is explored... Read more
    Hepatoma Res 2016;2:62-70. | doi:10.20517/2394-5079.2015.59
    Published on: 9 Mar 2016  | Viewed:17865  | Downloaded:452
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  • Coffee, Traditional Chinese Medicine and cannabinoids as potential tools for prevention and treatment of hepatocellular carcinoma

    Stefano Gitto , Ranka Vukotic , Pietro Andreone
    In the last decade, the incidence of hepatocellular carcinoma (HCC) is growing in both Europe and United States. Conventional therapies such as liver resection, transplantation, ablation, chemoembolization and sorafenib are not enough to avoid a significant mortality. Many studies suggested the positive effect of caffeine for prevention of HCC. Nevertheless, the amount of therapeutic caffeine... Read more
    Hepatoma Res 2016;2:71-7. | doi:10.20517/2394-5079.2015.63
    Published on: 9 Mar 2016  | Viewed:2892  | Downloaded:166
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  • Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise from diet-associated conditions such as non-alcoholic fatty liver disease and non-alcoholic... Read more
    Hepatoma Res 2016;2:53-61. | doi:10.20517/2394-5079.2015.64
    Published on: 9 Mar 2016  | Viewed:5313  | Downloaded:240
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  • Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Hepatoma Res 2015;1:107-8. | doi:10.4103/2394-5079.161626
    Published on: 15 Oct 2015  | Viewed:5078  | Downloaded:172
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  • Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Hepatoma Res 2015;1:109-10. | doi:10.4103/2394-5079.161332
    Published on: 15 Oct 2015  | Viewed:42435  | Downloaded:265
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  • Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in humans. Several researches have been reported numerous natural and phytochemical compounds that... Read more
    Hepatoma Res 2015;1:111-8. | doi:10.4103/2394-5079.167378
    Published on: 15 Oct 2015  | Viewed:8218  | Downloaded:555
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  • Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor response. Several studies aimed at discovering more molecules for the management of HCC. Those studies aimed... Read more
    Hepatoma Res 2015;1:119-24. | doi:10.4103/2394-5079.167379
    Published on: 15 Oct 2015  | Viewed:7006  | Downloaded:419
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  • Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were divided into 6 groups (8 rats each) and treated orally for 28 consecutive days as follows. Group 1: rats... Read more
    Hepatoma Res 2015;1:125-35. | doi:10.4103/2394-5079.167375
    Published on: 15 Oct 2015  | Viewed:10554  | Downloaded:380
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  • Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with different concentrations of AFB1 and/or FB1 for 24 and 48 h with or without aqueous extract of A.... Read more
    Hepatoma Res 2015;1:136-46. | doi:10.4103/2394-5079.167377
    Published on: 15 Oct 2015  | Viewed:7117  | Downloaded:222
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  • Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4... Read more
    Hepatoma Res 2015;1:147-54. | doi:10.4103/2394-5079.167376
    Published on: 15 Oct 2015  | Viewed:7607  | Downloaded:360
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Hepatoma Research ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)
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