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    Original Article| Open Access

    [18F]FDG PET imaging evaluation on non-alcoholic fatty liver disease and hepatocellular carcinoma model treated with sorafenib

    Fernando Gomes de Barros Costa , José Tadeu Stefano , Daniele de Paula Faria , Caio de Souza Levy , Maria Cristina Chammas , Camila de Godoi Carneiro , Isabel Veloso Alves Pereira , Bruno Cogliati , Flair José Carrilho , Claudia P. Oliveira

    Aim: Evaluate the effect of sorafenib in a rat model of non-alcoholic fatty liver disease (NAFLD) related to hepatocellular carcinoma (HCC) by quantifying the correlation between changes in glucose metabolism on PET imaging and degree of tumor differentiation. Methods: NAFLD related HCC was... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:35. | doi:10.20517/2394-5079.2018.06
    Published on: 12 Jul 2018  | Viewed:102  | Downloaded:1
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    Review| Open Access

    Somatostatin in hepatocellular carcinoma: experimental and therapeutic implications

    Elias Kouroumalis , Demetrius Samonakis , George Notas

    The neuropeptide somatostatin has been shown to control the secretion of several hormones and growth factors, but also to inhibit the proliferation of several tumor cells. Hepatocellular carcinoma (HCC) is a leading cause of death all over the world due to very limited treatment modalities. Early... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:34. | doi:10.20517/2394-5079.2018.33
    Published on: 11 Jul 2018  | Viewed:49  | Downloaded:3
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    Review| Open Access

    Living donor liver transplantation for patients with hepatocellular carcinoma in Japan

    Yasuhiko Sugawara , Hidekazu Yamamoto , Taizo Hibi

    Liver transplantation has now been an established treatment for hepatocellular carcinoma and cirrhosis. The Milan criteria have been accepted and applied widely in the world as an indication for deceased donor liver transplant. Due to the severe organ shortage, however, living donor liver... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:33. | doi:10.20517/2394-5079.2018.69
    Published on: 10 Jul 2018  | Viewed:120  | Downloaded:4
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    Review| Open Access

    The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

    Saranya Chidambaranathan-Reghupaty , Rachel Mendoza , Paul B. Fisher , Devanand Sarkar

    Staphylococcal nuclease and tudor domain containing 1 (SND1) is a protein that regulates a complex array of functions. It controls gene expression through transcriptional activation, mRNA degradation, mRNA stabilization, ubiquitination and alternative splicing. More than two decades of research... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:32. | doi:10.20517/2394-5079.2018.34
    Published on: 10 Jul 2018  | Viewed:114  | Downloaded:4
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    Review| Open Access

    Performance of different biomarkers for the management of hepatocellular carcinoma

    Ángela Rojas , Yolanda Sánchez-Torrijos , Antonio Gil-Gómez , Chang-Hai Liu , Clara Rodríguez-Rivas , María Teresa Ferrer , Manuel Romero-Gómez

    Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the second cause of cancer related death due to latent liver disease, late diagnosis and non-available therapeutic treatment. Liver biopsy is still the gold standard in order to know the molecular biology of the tumor,... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:31. | doi:10.20517/2394-5079.2018.60
    Published on: 6 Jul 2018  | Viewed:72  | Downloaded:14
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    Review| Open Access

    Oncogenic Wnt3a: a promising specific biomarker in hepatocellular carcinoma

    Min Yao , Miao Fang , Wen-Jie Zheng , Deng-Fu Yao

    Hepatocellular carcinoma (HCC) is still one of the most common and rapidly fatal malignancies worldwide with a multi-factorial, multi-step, complex process, and poor prognosis. Early discovery and effective therapy of HCC are of utmost importance. Recent studies demonstrated that Wnt/β-catenin... Read more

    Hepatoma Res 2018;4:30. | doi:10.20517/2394-5079.2018.32
    Published on: 5 Jul 2018  | Viewed:110  | Downloaded:12
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    Review| Open Access

    Understanding the inflammation-cancer transformation in the development of primary liver cancer

    Hong-Jin Chen , Ming-Hua Hu , Fang-Gui Xu , Hao-Jun Xu , Jun-Jun She , Hong-Ping Xia

    Primary liver cancer is one of the leading causes of cancer-related deaths worldwide. China has more than 55% liver cancer cases globally. The development of hepatocellular carcinoma (HCC) was caused by a variety of risks factors, including chronic inflammation by virus, alcohol consumption and... Read more

    Hepatoma Res 2018;4:29. | doi:10.20517/2394-5079.2018.18
    Published on: 5 Jul 2018  | Viewed:270  | Downloaded:23
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    Review| Open Access

    Pro-oncogenic role of SerpinB3 in hepatocellular carcinoma

    Andrea Martini , Patrizia Pontisso

    Hepatocellular carcinoma (HCC) is one of the most relevant sanitary problems for its prevalence and poor prognosis. This tumor is characterized by highly heterogeneous features, both at clinical and molecular level. SerpinB3 (squamous cell carcinoma antigen-1 or SCCA1) is a serine-protease... Read more

    This article belongs to the Special Issue New Insights in Liver Cancer Hepatoma Res 2018;4:28. | doi:10.20517/2394-5079.2018.50
    Published on: 29 Jun 2018  | Viewed:204  | Downloaded:24
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    Review| Open Access

    Hypoxic microenvironment and hepatocellular carcinoma treatment

    Ci-Ai Lin , Lin-Lin Chang , Hong Zhu , Qiao-Jun He , Bo Yang

    Hepatocellular carcinoma (HCC) is one of the most rapidly growing and prevalent cancers in the whole world. The characterized hypoxia region inside the HCC tumors has been recently found as the key driver of HCC malignance and treatment failure, leading to a variety of hypoxia-related biological... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:26. | doi:10.20517/2394-5079.2018.27
    Published on: 29 Jun 2018  | Viewed:167  | Downloaded:14
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    Original Article| Open Access

    Expression quantitative trait loci for PVT1 contributes to the prognosis of hepatocellular carcinoma

    Ting Tian , Ci Song , Zhe-Ning Pu , Zi-Jun Ge , Cheng-Xiao Yu , Ji-Bin Liu , Zhi-Bin Hu

    Aim: Plasmacytoma variant translocation 1 (PVT1), a long intergenic non-coding RNA, was overexpressed in liver cancer. A single nucleotide polymorphism (SNP) rs4733586 was identified as an expression quantitative trait loci (eQTL) for PVT1 using bioinformatics analysis. This study was to assess... Read more

    Hepatoma Res 2018;4:27. | doi:10.20517/2394-5079.2018.24
    Published on: 29 Jun 2018  | Viewed:159  | Downloaded:6
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