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    Review| Open Access

    Ablative techniques in hepatocellular carcinoma treatment

    Ehsun Naeem , Shahab Abid

    Hepatocellular carcinoma has been known to arise commonly in the setting of chronic liver disease. Due to its association with cirrhosis, patients with hepatocellular carcinoma often present with markedly diminished hepatic functional reserve, making them poor surgical candidates. For such... Read more

    This article belongs to the Special Issue What More We can do on Hepatitis C? Hepatoma Res 2018;4:18. | doi:10.20517/2394-5079.2018.22
    Published on: 13 Jun 2018  | Viewed:65  | Downloaded:10
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    Review| Open Access

    Pre-S2 and HBV associated hepatocellular carcinoma

    Ying Zheng , Yan-Yan Qian , Hong Fan

    Hepatitis B virus (HBV) infection is a primary cause of hepatocellular carcinoma (HCC). Under selection pressures of host immunity and/or immunoprophylaxis and antiviral therapies, HBV evolves by accumulating mutations in its genome. Several studies highlighted the considerable importance of HBV... Read more

    Hepatoma Res 2018;4:17. | doi:10.20517/2394-5079.2018.08
    Published on: 31 May 2018  | Viewed:281  | Downloaded:19
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    Review| Open Access

    T cell immunotherapy in hepatitis B virus related hepatocellular carcinoma

    Morteza Hafezi , Antonio Bertoletti , Anthony T. Tan

    Chronic hepatitis B Virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). While multiple treatment modalities are available, liver transplantation remains the sole curative treatment for advanced stages of HCC, and hence new treatment approaches are required to fulfill... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:16. | doi:10.20517/2394-5079.2018.55
    Published on: 30 May 2018  | Viewed:545  | Downloaded:31
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    Original Article| Open Access

    Hepatocellular carcinoma in patients without cirrhosis: relevance and clinical characteristics

    Kellyane Santana Dias Carvalho , Luciano E. Fonseca , Helma P. Cotrim

    Aim: The present study evaluated the frequency of hepatocellular carcinoma (HCC) in patients without cirrhosis. Methods: HCC patients were recruited from two reference centers for liver disease in Northeast Brazil from 2010 to 2016. The diagnosis of HCC and cirrhosis was based on international... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:15. | doi:10.20517/2394-5079.2018.13
    Published on: 29 May 2018  | Viewed:296  | Downloaded:26
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    Review| Open Access

    New strategy to distinguish clonal origin of RHCC/MHCC between intrahepatic metastasis and multicentric occurrence

    Han Wang , Wen-Ming Cong

    Hepatocellular carcinoma (HCC) is a kind of malignancy with high potential of metastasis and multicentric occurrence. The treatment of recurrent hepatocellular carcinoma (RHCC) and multinodular hepatocellular carcinoma (MHCC) is always a nodus because of the diverse clonal origin of RHCC/MHCC.... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:14. | doi:10.20517/2394-5079.2018.16
    Published on: 28 May 2018  | Viewed:411  | Downloaded:35
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    Original Article| Open Access

    Neoadjuvant hepatic arterial infusion chemotherapy for resectable hepatocellular carcinomas

    Rina Tsutsui , Hiroaki Nagamatsu , Osamu Itano , Akihiro Deguchi , Tsubasa Tsutsumi , Mamoru Hiraki , Naohisa Mizukami , Jun Akiba

    Aim: To evaluate the effect of neoadjuvant hepatic arterial infusion chemotherapy (HAIC) on the survival of patients with resectable hepatocellular carcinoma (HCC). Methods: Between January 2003 and January 2014, 80 patients underwent hepatic resection for HCC. Of these patients, we evaluated 49... Read more

    Hepatoma Res 2018;4:13. | doi:10.20517/2394-5079.2018.20
    Published on: 11 May 2018  | Viewed:976  | Downloaded:39
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    Original Article| Open Access

    Beta2-glycoprotein I cooperate with hepatitis B surface antigen promotes hepatocellular carcinogenesis via the nuclear factor kappa B signal pathway were enhanced by the lipopolysaccharide

    Xue-Li Ding , Xue Jing , Nai-Jun Han , Zi-Bin Tian , Pu-Jun Gao , Lin Yang , Ya-Nan Yu

    Aim: We aimed to elucidate whether beta2-glycoprotein I (β2GPI) cooperation with hepatitis B surface antigen (HBsAg) promoted hepatocellular carcinogenesis enhanced by the lipopolysaccharide (LPS) via activation of nuclear factor kappa B (NF-κB) and expression of tumor necrosis factor-α (TNF-α),... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:12. | doi:10.20517/2394-5079.2018.07
    Published on: 28 Apr 2018  | Viewed:400  | Downloaded:29
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    Review| Open Access

    Systemic therapies for hepatocellular carcinoma: a recap of the current status

    Petros Giovanis , Manuela De Bona , Fabio Farinati , Andrea Buda , Riccardo Berletti , Fable Zustovich , Simona D’Ippolito , Michele De Boni , Umberto Cillo , Davide Pastorelli

    After decades of frustrating nihilism due to lack of innovative therapeutic solutions, the onco-hepatological community is facing up to important novelties for the treatment of intermediate and advanced stages of liver cancer. Four new drugs have been investigated and resulted in positive data:... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:10. | doi:10.20517/2394-5079.2018.21
    Published on: 27 Apr 2018  | Viewed:863  | Downloaded:86
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    Original Article| Open Access

    A potential clinical based score in hepatitis C virus cirrhotic patients to exclude small hepatocellular carcinoma

    Denise Cerqueira Paranaguá-Vezozzo , Celso Eduardo Lourenço Matielo , Daniel Ferraz de Campos Mazo , Lucas Souto Nacif , Mario Guimaraes Pessoa , Gleicy Luz Reinoso Pereira , Roque Gabriel Rezende de Lima , Patricia Momoyo Yoshimura Zitelli , Suzane Kioko Ono , Flair José Carrilho

    Aim: Hepatitis C virus (HCV) cirrhosis is an important cause of hepatocellular carcinoma (HCC). This study aimed to identify factors of HCC presence among HCV cirrhotic patients with and without small diameter HCC (≤ 3 cm). Methods: A case control transversal study between 1998 and 2003 including... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:11. | doi:10.20517/2394-5079.2018.17
    Published on: 27 Apr 2018  | Viewed:685  | Downloaded:50
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    Original Article| Open Access

    Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

    Nisha Bhatia , Baljinder Singh , Ashwani Koul

    Aim: The present study was aimed to determine the modulatory role of lycopene enriched tomato extract (LycT) during initiation of N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma (HCC). Methods: Female Balb/c mice were divided into 4 groups: control, NDEA (200 mg NDEA/kg b.wt,... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:9. | doi:10.20517/2394-5079.2018.04
    Published on: 27 Mar 2018  | Viewed:717  | Downloaded:22
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