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    Review| Open Access

    Role of early growth response 1 in liver metabolism and liver cancer

    Nancy Magee , Yuxia Zhang

    The liver is an essential organ for nutrient and drug metabolism - possessing the remarkable ability to sense environmental and metabolic stimuli and provide an optimally adaptive response. Early growth response 1 (Egr1), an immediate early transcriptional factor which acts as a coordinator of... Read more

    Hepatoma Res 2017;3:268-77. | doi:10.20517/2394-5079.2017.36
    Published on: 20 Nov 2017  | Viewed:20  | Downloaded:3
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    Original Article| Open Access

    Neoplastic macrovascular invasion represents an independent risk factor for dismal survival in sorafenib treatment for hepatocellular carcinoma

    Michele Lecchini , Andrea Olivani , Elisabetta Biasini , Raffaele Dalla Valle , Carlo Ferrari , Gabriele Missale , Claudia Schianchi

    Aim: Sorafenib efficacy and safety in advanced hepatocellular carcinoma (HCC) have been demonstrated in two randomized international clinical trials and in clinical practice studies. Because of poor survival advantage, to identify clinical and biological parameters remains an unmet clinical need.... Read more

    Hepatoma Res 2017;3:260-7. | doi:10.20517/2394-5079.2017.44
    Published on: 16 Nov 2017  | Viewed:134  | Downloaded:17
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    Viewpoint of Editor-in-Chief| Open Access

    Cancer Evo-Dev, a novel hypothesis derived from studies on hepatitis B virus-induced carcinogenesis

    Guang-Wen Cao

    Non-resolving inflammation, which may be maintained by infection, pollution, and metabolic stimulants and their interactions with immunogenetic predisposition, provides a fertile field for cancer development. This is strongly evident in hepatocellular carcinoma. Here, the framework of a... Read more

    Hepatoma Res 2017;3:241-59. | doi:10.20517/2394-5079.2017.45
    Published on: 27 Oct 2017  | Viewed:1016  | Downloaded:69
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    Review| Open Access

    Reducing liver cancer risk beginning at birth: experiences of preventing chronic hepatitis B virus infection in China

    Chunfeng Qu , Zhongping Duan , Kun Chen , Huaibin Zou

    In China, the death numbers due to primary liver cancer every year account for more than half of this disease burden worldwide. Hepatocellular carcinoma (HCC) represents the major histological type of primary liver cancer. In the Chinese population, at least 85% HCC cases are due to chronic... Read more

    Hepatoma Res 2017;3:228-40. | doi:10.20517/2394-5079.2017.41
    Published on: 25 Oct 2017  | Viewed:799  | Downloaded:42
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    Review| Open Access

    Interventional radiology for post-transplant anastomotic complications

    Toshiya Shibata

    The effectiveness of percutaneous interventional radiology for anastomotic stricture in hepatic vein, portal vein, and biliary tract after living donor liver transplantation (LDLT) is described. As a number of patients with LDLT are infants < 10-year-old in the study, the first treatment... Read more

    Hepatoma Res 2017;3:221-7. | doi:10.20517/2394-5079.2017.34
    Published on: 25 Oct 2017  | Viewed:220  | Downloaded:6
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    Original Article| Open Access

    Efficacy and HCC development after DAA therapy for patients with chronic hepatitis C: a single center retrospective cohort study

    Akitoshi Douhara , Hiroyuki Ogawa , Satoshi Nakatani , Takahiro Ozutsumi , Erika Shioyama , Masaaki Yoshikawa , Shigehiko Ueda

    Aim: The development of hepatocellular carcinoma (HCC) is reduced after interferon based treatment in patients with chronic hepatitis C (CHC). A new therapy using direct-acting antiviral agents (DAA) has been widely applied since 2014 for CHC. The purpose of this study is to investigate the... Read more

    Hepatoma Res 2017;3:215-20. | doi:10.20517/2394-5079.2017.32
    Published on: 17 Oct 2017  | Viewed:249  | Downloaded:20
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    Original Article| Open Access

    Clinical outcomes of direct-acting antiviral therapy in patients with compensated hepatitis C virus-related cirrhosis

    Estefania Berge , Ana Arencibia , Elena Otón , Luis Cejas , Silvia Acosta , Francisco Pérez

    Aim: The aim was to assess the clinical impact of direct-acting antiviral treatment in patients with compensated hepatitis C virus-related cirrhosis after one year of follow-up. Methods: An observational retrospective study was conducted on 129 consecutive patients with compensated cirrhosis... Read more

    Hepatoma Res 2017;3:209-14. | doi:10.20517/2394-5079.2017.28
    Published on: 27 Sep 2017  | Viewed:240  | Downloaded:23
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    Case Report| Open Access

    Total regression of hepatocellular carcinoma bone metastases, after liver transplantation, with sorafenib-everolimus

    Dimitrios Giakoustidis , Athanasios Apostolos Gargavanis , Nikolaos Salveridis , Evangelos Cholongitas , Emmanouil Sinakos , Konstantinos Papapolychroniadis , Vasileios Papanikolaou

    Hepatocellular carcinoma (HCC) represents the 5th commonest malignancy worldwide. Liver transplantation consist a radical and most efficient treatment for HCC. Tumor recurrence or metastases after liver transplantation is not uncommon. Hereby is presented a case of a patient transplanted for... Read more

    Hepatoma Res 2017;3:205-8. | doi:10.20517/2394-5079.2017.29
    Published on: 20 Sep 2017  | Viewed:246  | Downloaded:21
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    Topic: Management of Huge and Advanced Hepatocellular Carcinoma| Open Access

    Outcomes of emergency and interval hepatectomy for ruptured resectable hepatocellular carcinoma: a single tertiary referral centre experience

    Andrew Kai Yip Fung , Charing Ching Ning Chong , Kit Fai Lee , John Wong , Yue Sun Cheung , Anthony Kwong Wai Fong , Paul Bo San Lai

    Aim: The short and long term outcomes of patients who underwent emergency and interval hepatectomy for ruptured and resectable hepatocellular carcinoma (HCC) were analysed. Methods: The data of patients with ruptured HCC presenting between April 2004 and October 2015 were analysed. Emergency... Read more

    Hepatoma Res 2017;3:196-204. | doi:10.20517/2394-5079.2017.23
    Published on: 8 Sep 2017  | Viewed:533  | Downloaded:35
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    Topic: Management of Huge and Advanced Hepatocellular Carcinoma| Open Access

    Surgical strategy for huge and advanced hepatocellular carcinoma in Hong Kong

    Kenneth S.H. Chok

    In Hong Kong, surgical resection is the core curative treatment for huge and advanced hepatocellular carcinoma (HCC). For tumors measuring 10 cm or above, major hepatectomy is usually required, but a future liver remnant not large enough will preclude the operation. Hypertrophy of future liver... Read more

    Hepatoma Res 2017;3:189-95. | doi:10.20517/2394-5079.2017.33
    Published on: 3 Sep 2017  | Viewed:723  | Downloaded:56
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