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    Review| Open Access

    Screening for hepatocellular carcinoma: summary of current guidelines up to 2018

    Nevin Yilmaz, Ugur Eser Yilmaz, Kaya Suer, Vedat Goral, Nedim Cakir

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related to worldwide death with a great geographical variation. To be eligible for curative therapy at the time of diagnosis is important. However, the majority of cases are diagnosed at late stages. This can be achieved with... Read more

    Hepatoma Res 2018;4:46. | doi:10.20517/2394-5079.2018.49
    Published on: 16 Aug 2018  | Viewed:0  | Downloaded:0
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    Opinion| Open Access

    Elimination of hepatitis from Pakistan by 2030: is it possible?

    Yasir Waheed, Masood Siddiq

    Globally 71 million people are living with hepatitis C virus (HCV) out which 7.1 million (10%) are present in Pakistan. Genotype 3 is the most common HCV type in the country. World Health Organization is working with health authorities in different countries for effective control of HCV, to... Read more

    This article belongs to the Special Issue What More We can do on Hepatitis C? Hepatoma Res 2018;4:45. | doi:10.20517/2394-5079.2018.58
    Published on: 14 Aug 2018  | Viewed:158  | Downloaded:3
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    Review| Open Access

    Exosome-based liquid biopsy in the management of hepatocellular carcinoma

    Aparna Jayachandran, Sasidhar Venkata Manda, Ritu Shrestha, Kim R. Bridle, Prashanth Prithviraj, Darrell H. G. Crawford

    Hepatocellular carcinoma (HCC) commonly presents at an advanced stage due to the lack of efficient early screening tools. Early, non-invasive biomarkers useful in the diagnosis and prognosis of HCC would be of significant benefit for HCC management. Development of exosome-based liquid biopsy as a... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:44. | doi:10.20517/2394-5079.2018.59
    Published on: 13 Aug 2018  | Viewed:24  | Downloaded:2
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    Review| Open Access

    Factors predicting hepatocellular carcinoma in hepatitis C infection

    Zaigham Abbas, Minaam Abbas

    Hepatitis C virus (HCV) has emerged as a leading cause of hepatocellular carcinoma (HCC). In most cases, the virus causes HCC in the presence of chronic hepatic inflammation, advanced fibrosis, and cirrhosis. A combination of viral, environmental, and genetic factors are likely to determine the... Read more

    This article belongs to the Special Issue What More We can do on Hepatitis C? Hepatoma Res 2018;4:43. | doi:10.20517/2394-5079.2018.26
    Published on: 8 Aug 2018  | Viewed:80  | Downloaded:4
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    Review| Open Access

    Molecular mechanism of hepatocellular carcinoma

    Seung Kew Yoon

    Development of hepatocellular carcinoma (HCC) is very complex and occurs through a multistep biological process of malignant transformation of normal hepatocytes in which various factors, including genetic and epigenetic alterations, regulation of oxidative stress, inflammation, and immunity are... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:42. | doi:10.20517/2394-5079.2018.23
    Published on: 8 Aug 2018  | Viewed:153  | Downloaded:20
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    Original Article| Open Access

    Heat shock reduces HCV replication via regulation of ribosomal L22 in Alu-RNA molecule dependent manner

    Hamada Farghaly, Adel A. Guirgis, Hany Khalil

    Aim: Hepatitis C virus (HCV) infection is a global health problem that affects more than 180 million people worldwide. HCV is associated with several hepatic and other hepatic disorders including malignancies. HCV is a small enveloped positive-single strand RNA virus that belongs to Hepacivirus... Read more

    This article belongs to the Special Issue What More We can do on Hepatitis C? Hepatoma Res 2018;4:41. | doi:10.20517/2394-5079.2018.30
    Published on: 7 Aug 2018  | Viewed:142  | Downloaded:13
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    Review| Open Access

    Immunotherapy: a new era for hepatocellular carcinoma

    Ya-Jing He, Ya-Bing Guo, Wei Zhu, Yu-Kai He, Jin-Lin Hou

    Cancer is a major disease threatening human health. The overall prognosis for hepatocellular carcinoma (HCC) patients is poor, with a dismal 5-year survival rate of approximately 5%-30%. The dysfunction of immune system plays a pivotal role in the development of cancer, which has attracted... Read more

    Hepatoma Res 2018;4:40. | doi:10.20517/2394-5079.2018.45
    Published on: 6 Aug 2018  | Viewed:250  | Downloaded:8
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    Review| Open Access

    Oxidative stress and hepatocarcinogenesis

    Ying Fu, Fung-Lung Chung

    Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. There are two major challenges for HCC, the first being that early detection is generally not applicable, and secondly, it is usually fatal within several months after diagnosis. HCC is an... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:39. | doi:10.20517/2394-5079.2018.29
    Published on: 1 Aug 2018  | Viewed:511  | Downloaded:67
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    Review| Open Access

    Fat and hepatocellular carcinoma

    Clara Balsano, Cristiana Porcu, Silvia Sideri, Simona Tavolaro

    Obesity and diabetes are associated with the onset of hepatocellular carcinoma (HCC). These two illnesses correlate also with the development of non-alcoholic fatty liver disease (NAFLD). Currently, NAFL is considered the leading form of chronic liver disease in the Western industrialized... Read more

    This article belongs to the Special Issue New Insights in Liver Cancer Hepatoma Res 2018;4:38. | doi:10.20517/2394-5079.2018.51
    Published on: 25 Jul 2018  | Viewed:673  | Downloaded:94
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    Review| Open Access

    Aberrant pre-mRNA splicing regulation in the development of hepatocellular carcinoma

    Supriya Sen

    Alternative splicing is a highly regulated process that plays a critical role in diversification of the transcriptome and proteome in the cell. Several diseases, including different types of cancers, have been associated with aberrant regulation of alternative splicing. Thus, correcting... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:37. | doi:10.20517/2394-5079.2018.39
    Published on: 18 Jul 2018  | Viewed:163  | Downloaded:6
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