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    Review| Open Access

    Alpha-fetoprotein as a predictor of hepatocellular carcinoma recurrence following liver transplantation

    Evangelia M. Fatourou, Abid R. Suddle, Michael A. Heneghan

    Alpha-fetoprotein (AFP) has been increasingly recognised as a valuable marker in predicting HCC recurrence post-liver transplantation. Moreover, its secretion has been associated with poor histological tumour characteristics as it reflects an aggressive tumour biological behaviour. This review... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:63. | doi:10.20517/2394-5079.2018.62
    Published on: 10 Oct 2018  | Viewed:197  | Downloaded:11
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    Review| Open Access

    Liver transplantation for hepatocellular carcinoma - non-cancer factors and implications for improving outcome beyond standard tumor criteria

    Arno Kornberg, Martina Schernhammer

    Liver transplantation (LT) is recognized as best treatment option in patients with early hepatocellular cancer (HCC) in underlying liver cirrhosis. Apart from tumor size and number implemented in the Milan criteria, which are current worldwide standards for patient selection, several biological... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:60. | doi:10.20517/2394-5079.2018.86
    Published on: 29 Sep 2018  | Viewed:194  | Downloaded:8
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    Original Article| Open Access

    Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation

    James Fung, Danny Ka-Ho Wong, Yasuhito Tanaka, Regina Lo, Tiffany Wong, Kenneth Siu-Ho Chok, Albert Chi-Yan Chan, Tan-To Cheung, Wing-Chiu Dai, Kelvin Ng, Kevin Ng, Man Kwan, Irene Ng, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen, Chung-Mau Lo

    Aim: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for chronic hepatitis B (CHB) can be associated with reappearance of hepatitis B surface antigen (HBsAg). The current study determined the significance of HBsAg qualitatively and quantitatively using a highly... Read more

    Hepatoma Res 2018;4:62. | doi:10.20517/2394-5079.2018.92
    Published on: 29 Sep 2018  | Viewed:271  | Downloaded:11
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    Original Article| Open Access

    Novel diagnosis and therapy for hepatoma targeting HBV-related carcinogenesis through alternative splicing of FIR (PUF60)/FIRΔexon2

    Kazuyuki Matsushita, Tyuji Hoshino

    Aim: Disturbed alternative splicing of far upstream element-binding protein-interacting repressor (FIR) was found to be unable to repress c-Myc transcription and so it might be important for suppressing tumor development. FIR is a splicing variant of poly (U)-binding-splicing factor (PUF60), and... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:61. | doi:10.20517/2394-5079.2018.81
    Published on: 29 Sep 2018  | Viewed:294  | Downloaded:15
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    Review| Open Access

    Role of the contrast-enhanced ultrasoud in the diagnosis of HCC in cirrhotic liver

    Francesco Loria, Antonello Parlati, Giuseppe Loria, Luciano Frosina, Giuseppe Crea, Salvatore Basile, Caterina Alessio, Giuseppe Di Leo, Adele De Caridi, Vittorio Maschio, Nicola Zizzi, Orazio Trapuzzano, Salvatore Giuseppe Galea

    The development of second generation ultrasound (US) contrast-medium and specific imaging techniques with dedicated softwares, allows to observe the liver perfusion in real time, becoming an useful and less invasive method to describe precisely the vascularization of hepatic lesions. This... Read more

    This article belongs to the Special Issue New Insights in Liver Cancer Hepatoma Res 2018;4:59. | doi:10.20517/2394-5079.2018.75
    Published on: 28 Sep 2018  | Viewed:230  | Downloaded:14
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    Review| Open Access

    Staging of hepatocellular carcinoma

    Sedat Karademir

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths in the world. In contrast to other cancers, survival of patients with HCC is determined by the extent of the tumor in addition to underlying liver disease and its functional reserve. From risk factors to management, HCC... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:58. | doi:10.20517/2394-5079.2018.40
    Published on: 26 Sep 2018  | Viewed:163  | Downloaded:8
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    Review| Open Access

    New insights on hepatocellular carcinoma: epidemiology and clinical aspects

    Claudio Puoti

    Primary liver cancer represents the 4th most common tumor in males (4% of all cancers) and the 7th most common tumor in females (2.3% of all cancers), with a prevalence of 53/100,000 in males and 22/100,000 in females (male-to-female ratio = 2:1). In the majority of the cases, hepatocellular... Read more

    This article belongs to the Special Issue New Insights in Liver Cancer Hepatoma Res 2018;4:57. | doi:10.20517/2394-5079.2018.67
    Published on: 21 Sep 2018  | Viewed:249  | Downloaded:18
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    Review| Open Access

    Mechanisms and clinical behavior of hepatocellular carcinoma in HBV and HCV infection and alcoholic and non-alcoholic fatty liver disease

    Riccardo Nevola, Luca Rinaldi, Mauro Giordano, Aldo Marrone, Luigi Elio Adinolfi

    Hepatocellular carcinoma (HCC) is the main tumor of the liver and is the sixth most frequently diagnosed tumor in the world. It is the evolution of chronic hepatic injury secondary to different etiologies. Chronic hepatitis B virus and hepatitis C virus infection, chronic alcoholic hepatitis, as... Read more

    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma Hepatoma Res 2018;4:55. | doi:10.20517/2394-5079.2018.38
    Published on: 20 Sep 2018  | Viewed:275  | Downloaded:22
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    Review| Open Access

    HCV-discovery to elimination, “myth or reality”

    Wasim Jafri, Basit Siddiqui, Safia Awan

    Hepatitis C virus (HCV) was discovered in 1989, before that it was commonly known as transfusion associated non A non B hepatitis. It rapidly assumed the role of leading cause of cirrhosis and liver cancer and a leading indication for liver transplant globally. For over two decades the treatment... Read more

    This article belongs to the Special Issue What More We can do on Hepatitis C? Hepatoma Res 2018;4:54. | doi:10.20517/2394-5079.2018.36
    Published on: 20 Sep 2018  | Viewed:161  | Downloaded:9
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    Original Article| Open Access

    Adult African Americans undergoing cadaveric liver transplantation for hepatocellular carcinoma within the Milan criteria have the lowest 5-year survival among all the ethnic groups in the United States: analysis of USA national data between January 2002

    Michele Molinari, Subhashini Ayloo, Allan Tsung, Patrick Bou Samra, Naudia Jonaissaint

    Aim: To investigate the potential effects of recipient ethnicity on the short and long-term outcomes of patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) in the United States. We performed a retrospective study using the standard transplant analysis and research... Read more

    This article belongs to the Special Issue Management of Hepatocellular Carcinoma Hepatoma Res 2018;4:56. | doi:10.20517/2394-5079.2018.71
    Published on: 20 Sep 2018  | Viewed:160  | Downloaded:8
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