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    Review| Open Access

    Direct antiviral therapy for hepatitis C and hepatocellular carcinoma: facing the conundrum

    Federica Buonfiglioli , Stefano Brillanti

    Direct antiviral therapy has dramatically changed our possibility to eradicate hepatitis C virus (HCV) infection in all stages of chronic liver disease, with sustained virological response rates well above 90%. HCV eradication should lead to a better prognosis even after cirrhosis has... Read more

    Hepatoma Res 2018;4:6. | doi:10.20517/2394-5079.2017.42
    Published on: 10 Feb 2018  | Viewed:208  | Downloaded:25
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    Review| Open Access

    Treatment of high-burden hepatocellular carcinoma: an oncologist perspective

    Landon L. Chan , Stephen L. Chan

    Hepatocellular carcinoma (HCC) is recognized as a major global healthcare burden. Although there have been tremendous improvements in cancer screening and treatment, HCC mortality rate remains high. Many patients with HCC present late to medical attention and thus are not candidates for curative... Read more

    Hepatoma Res 2018;4:5. | doi:10.20517/2394-5079.2017.49
    Published on: 7 Feb 2018  | Viewed:351  | Downloaded:13
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    Cohort Profile| Open Access

    Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer

    Tao-Yang Chen , Geng-Sun Qian , Chun-Sun Fan , Yan Sun , Jin-Bing Wang , Pei-Xin Lu , Xue-Feng Xue , Yan Wu , Qi-Nan Zhang , Yan Jin , Yi-Qian Wu , Yu Gan , Jian-Quan Lu , Thomas W. Kensler , John D. Groopman , Hong Tu

    Qidong hepatitis B virus (HBV) infection cohort (QBC) is a prospective community-based study designed to investigate causative factors of primary liver cancer (PLC) in Qidong, China, where both PLC and HBV infection are highly endemic. Residents aged 20-65 years, living in seven townships of... Read more

    Hepatoma Res 2018;4:4. | doi:10.20517/2394-5079.2017.50
    Published on: 26 Jan 2018  | Viewed:786  | Downloaded:22
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    Original Article| Open Access

    Hepatocellular carcinoma in the setting of Interferon-free treatment for chronic HCV hepatitis - experience of a single center

    Elena Laura Iliescu , Adriana Mercan-Stanciu , Letitia Toma , Elena Simona Ioanitescu , Radu Dumitru , Daniel Rusie

    Aim: This study aims to analyze the particularities of hepatitis C induced hepatocellular carcinoma (HCC), developed during or after treatment with direct-acting antivirals. Methods: We conducted an observational prospective study on 278 patients, who underwent treatment for hepatitis C related... Read more

    Hepatoma Res 2018;4:3. | doi:10.20517/2394-5079.2017.48
    Published on: 18 Jan 2018  | Viewed:749  | Downloaded:15
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    Original Article| Open Access

    Comparison of outcomes between laparoscopic vs. open liver resection for intermediate stage hepatocellular carcinoma

    Avril David , YoungRok Choi , Ho-Seong Han , Yoo-Seok Yoon , Jai Young Cho

    Aim: The Barcelona Clinic Liver Score (BCLC) currently limits hepatic resection only for small, solitary tumors measuring 2-3 cm with no signs of portal hypertension (PHT) or macrovascular invasion. The aim of this study was to show the benefit of surgical resection, and to compare the... Read more

    This article belongs to the Special Issue Management of Huge and Advanced Hepatocellular Carcinoma Hepatoma Res 2018;4:2. | doi:10.20517/2394-5079.2017.51
    Published on: 18 Jan 2018  | Viewed:447  | Downloaded:29
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    Original Article| Open Access

    Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort

    Scott T. Nishioka , Miles M. Sato , Linda L. Wong , Maarit Tiirikainen , Sandi A. Kwee

    Aim: Increased serum alpha-fetoprotein (AFP) levels are associated with specific molecular sub-classes of hepatocellular carcinoma (HCC), supporting AFP as a predictive or therapeutic biomarker for precision treatment of this disease. Considering recent efforts to validate HCC molecular... Read more

    Hepatoma Res 2018;4:1. | doi:10.20517/2394-5079.2017.46
    Published on: 12 Jan 2018  | Viewed:1139  | Downloaded:50
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    Topic: Novel Approaches for HCC| Open Access

    The impact of nucleos(t)ide analog therapy in hepatitis B on the incidence of hepatocellular carcinoma: an update including recent literature findings

    Walid S. Ayoub , Francis Dailey , Paul Martin , Patricia D. Jones

    Worldwide, hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality. In men, it is the fifth most common cancer and seventh most common in women; HCC is the second highest cause of cancer-related death worldwide. It is less prevalent in the USA and Northern Europe and more... Read more

    Hepatoma Res 2017;3:302-8. | doi:10.20517/2394-5079.2016.44
    Published on: 20 Dec 2017  | Viewed:316  | Downloaded:22
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    Original Article| Open Access

    Association of serum levels of transforming growth factor β1 with disease severity in patients with hepatocellular carcinoma

    Mohamed Ahmed Samy Kohla , Ahmed Attia , Nehad Darwesh , Manar Obada , Hossam Taha , Marwa F. Youssef

    Aim: Transforming growth factor (TGF) is overexpressed by tumor cells like other proteins and growth factors. TGF-β1 is then activated in the extracellular compartment but is unable to control cell proliferation because of the absence or low level of TGF-β1 receptors on the plasma membrane of... Read more

    Hepatoma Res 2017;3:294-301. | doi:10.20517/2394-5079.2017.40
    Published on: 12 Dec 2017  | Viewed:385  | Downloaded:29
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    Topic: Management of Huge and Advanced Hepatocellular Carcinoma| Open Access

    The role of oral antiviral therapy in hepatitis B-related hepatocellular carcinoma

    James Fung , Kenneth S.H. Chok

    Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) in places where chronic hepatitis B infection is endemic. Oral nucleos(t)ide analog (NA) therapy can reduce the risk of HCC, but cannot completely prevent its development. For HBV-related HCCs, viral inhibition by NAs... Read more

    Hepatoma Res 2017;3:284-93. | doi:10.20517/2394-5079.2017.38
    Published on: 27 Nov 2017  | Viewed:421  | Downloaded:25
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    Topic: Management of Huge and Advanced Hepatocellular Carcinoma| Open Access

    Robotic hepatectomy for hepatocellular carcinoma: a clinical review

    Eric C.H. Lai , Daniel T.M. Chung , Oliver C.Y. Chan , Chung Ngai Tang

    The robotic surgical system was developed to overcome the disadvantages of conventional laparoscopic surgery. The use of robots in liver surgery was not well evaluated. This article aimed at reviewing robotic partial hepatectomy to conventional laparoscopic or open partial hepatectomy in terms of... Read more

    Hepatoma Res 2017;3:278-83. | doi:10.20517/2394-5079.2017.37
    Published on: 27 Nov 2017  | Viewed:586  | Downloaded:9
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