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    Original Article| Open Access

    Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

    Nisha Bhatia , Baljinder Singh , Ashwani Koul

    Aim: The present study was aimed to determine the modulatory role of lycopene enriched tomato extract (LycT) during initiation of N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma (HCC). Methods: Female Balb/c mice were divided into 4 groups: control, NDEA (200 mg NDEA/kg b.wt,... Read more

    Hepatoma Res 2018;4:9. | doi:10.20517/2394-5079.2018.04
    Published on: 27 Mar 2018  | Viewed:376  | Downloaded:7
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    Original Article| Open Access

    Prediction of post-progression survival in patients with advanced hepatocellular carcinoma treated with sorafenib by using time-dependent changes in clinical characteristics

    Yoshiyuki Wada , Yuko Takami , Hajime Matsushima , Masaki Tateishi , Tomoki Ryu , Munehiro Yoshitomi , Hideki Saitsu

    Aim: Sorafenib has been shown to improve time to tumor progression (TTP) and overall survival (OS) in patients with hepatocellular carcinoma (HCC); however, post-progression survival (PPS) has not been well characterized in these patients. This study aimed to evaluate the predictors of PPS by... Read more

    Hepatoma Res 2018;4:8. | doi:10.20517/2394-5079.2017.39
    Published on: 6 Mar 2018  | Viewed:966  | Downloaded:71
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    Case Report| Open Access

    Congenital absence of the portal vein complicated by hepatocellular carcinoma in the liver of an adult woman: review of imaging, literature and management

    Ankit Mehta , Shree R. Venkat , Lorraine Portelance , Lynn G. Feun

    We present a case of absence of the portal vein and Laennec’s cirrhosis in a 51-year-old female who was diagnosed with hepatocellular carcinoma (HCC). Only 101 cases of this malformation of the splanchnic vasculature have been reported of which 4 were reported to have HCC. Patient had disease... Read more

    This article belongs to the Special Issue Novel Approaches for HCC Hepatoma Res 2018;4:7. | doi:10.20517/2394-5079.2017.35
    Published on: 27 Feb 2018  | Viewed:1211  | Downloaded:44
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    Review| Open Access

    Direct antiviral therapy for hepatitis C and hepatocellular carcinoma: facing the conundrum

    Federica Buonfiglioli , Stefano Brillanti

    Direct antiviral therapy has dramatically changed our possibility to eradicate hepatitis C virus (HCV) infection in all stages of chronic liver disease, with sustained virological response rates well above 90%. HCV eradication should lead to a better prognosis even after cirrhosis has... Read more

    Hepatoma Res 2018;4:6. | doi:10.20517/2394-5079.2017.42
    Published on: 10 Feb 2018  | Viewed:1885  | Downloaded:137
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    Review| Open Access

    Treatment of high-burden hepatocellular carcinoma: an oncologist perspective

    Landon L. Chan , Stephen L. Chan

    Hepatocellular carcinoma (HCC) is recognized as a major global healthcare burden. Although there have been tremendous improvements in cancer screening and treatment, HCC mortality rate remains high. Many patients with HCC present late to medical attention and thus are not candidates for curative... Read more

    This article belongs to the Special Issue Management of Huge and Advanced Hepatocellular Carcinoma Hepatoma Res 2018;4:5. | doi:10.20517/2394-5079.2017.49
    Published on: 7 Feb 2018  | Viewed:1504  | Downloaded:87
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    Cohort Profile| Open Access

    Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer

    Tao-Yang Chen , Geng-Sun Qian , Chun-Sun Fan , Yan Sun , Jin-Bing Wang , Pei-Xin Lu , Xue-Feng Xue , Yan Wu , Qi-Nan Zhang , Yan Jin , Yi-Qian Wu , Yu Gan , Jian-Quan Lu , Thomas W. Kensler , John D. Groopman , Hong Tu

    Qidong hepatitis B virus (HBV) infection cohort (QBC) is a prospective community-based study designed to investigate causative factors of primary liver cancer (PLC) in Qidong, China, where both PLC and HBV infection are highly endemic. Residents aged 20-65 years, living in seven townships of... Read more

    Hepatoma Res 2018;4:4. | doi:10.20517/2394-5079.2017.50
    Published on: 26 Jan 2018  | Viewed:1797  | Downloaded:70
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    Original Article| Open Access

    Hepatocellular carcinoma in the setting of interferon-free treatment for chronic HCV hepatitis - experience of a single center

    Elena Laura Iliescu , Adriana Mercan-Stanciu , Letitia Toma , Elena Simona Ioanitescu , Radu Dumitru , Daniel Rusie

    Aim: This study aims to analyze the particularities of hepatitis C induced hepatocellular carcinoma (HCC), developed during or after treatment with direct-acting antivirals. Methods: We conducted an observational prospective study on 278 patients, who underwent treatment for hepatitis C related... Read more

    Hepatoma Res 2018;4:3. | doi:10.20517/2394-5079.2017.48
    Published on: 18 Jan 2018  | Viewed:1539  | Downloaded:52
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    Original Article| Open Access

    Comparison of outcomes between laparoscopic vs. open liver resection for intermediate stage hepatocellular carcinoma

    Avril David , YoungRok Choi , Ho-Seong Han , Yoo-Seok Yoon , Jai Young Cho

    Aim: The Barcelona Clinic Liver Score (BCLC) currently limits hepatic resection only for small, solitary tumors measuring 2-3 cm with no signs of portal hypertension (PHT) or macrovascular invasion. The aim of this study was to show the benefit of surgical resection, and to compare the... Read more

    This article belongs to the Special Issue Management of Huge and Advanced Hepatocellular Carcinoma Hepatoma Res 2018;4:2. | doi:10.20517/2394-5079.2017.51
    Published on: 18 Jan 2018  | Viewed:967  | Downloaded:59
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    Original Article| Open Access

    Clinical and molecular sub-classification of hepatocellular carcinoma relative to alpha-fetoprotein level in an Asia-Pacific island cohort

    Scott T. Nishioka , Miles M. Sato , Linda L. Wong , Maarit Tiirikainen , Sandi A. Kwee

    Aim: Increased serum alpha-fetoprotein (AFP) levels are associated with specific molecular sub-classes of hepatocellular carcinoma (HCC), supporting AFP as a predictive or therapeutic biomarker for precision treatment of this disease. Considering recent efforts to validate HCC molecular... Read more

    Hepatoma Res 2018;4:1. | doi:10.20517/2394-5079.2017.46
    Published on: 12 Jan 2018  | Viewed:2282  | Downloaded:94
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    Topic: Novel Approaches for HCC| Open Access

    The impact of nucleos(t)ide analog therapy in hepatitis B on the incidence of hepatocellular carcinoma: an update including recent literature findings

    Walid S. Ayoub , Francis Dailey , Paul Martin , Patricia D. Jones

    Worldwide, hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality. In men, it is the fifth most common cancer and seventh most common in women; HCC is the second highest cause of cancer-related death worldwide. It is less prevalent in the USA and Northern Europe and more... Read more

    Hepatoma Res 2017;3:302-8. | doi:10.20517/2394-5079.2016.44
    Published on: 20 Dec 2017  | Viewed:659  | Downloaded:64
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