Published Special Issues
Topic: Natural Products and Hepatocellular Carcinoma
  • Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Published on: 15 Oct 2015
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  • Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise from diet-associated conditions such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Furthermore, toxins and nutrients such as mycotoxins and alcohol have an established role in the pathogenesis of chronic liver diseases, whereas specific diet patterns or foods have been...
    Published on: 9 Mar 2016
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  • Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Published on: 15 Oct 2015
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  • Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse effects owing to chemotherapy and recurrence. The role of Curcumin as an adjuvant remedy is explored in this article. Curcumin stimulates apoptosis of cancer cells, acts as anti-proliferative agent, has anti-angiogenic action, prevents tumor invasiveness and metastasis and prevents recurrence. It also...
    Published on: 9 Mar 2016
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  • Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in humans. Several researches have been reported numerous natural and phytochemical compounds that may counteract or prevent the hepatic injury and primary liver cancer. The conservative treatment of liver toxicity and HCC may face awkward challenges in chemotherapy such as therapeutic failure or...
    Published on: 15 Oct 2015
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  • Coffee, Traditional Chinese Medicine and cannabinoids as potential tools for prevention and treatment of hepatocellular carcinoma

    Stefano Gitto , Ranka Vukotic , Pietro Andreone
    In the last decade, the incidence of hepatocellular carcinoma (HCC) is growing in both Europe and United States. Conventional therapies such as liver resection, transplantation, ablation, chemoembolization and sorafenib are not enough to avoid a significant mortality. Many studies suggested the positive effect of caffeine for prevention of HCC. Nevertheless, the amount of therapeutic caffeine and the high-dose safety are unknown. Many authors proposed Traditional Chinese Medicine as preventive and/or curative approach. Although it reveals limits such as the uncertain safety profile and the...
    Published on: 9 Mar 2016
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  • Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor response. Several studies aimed at discovering more molecules for the management of HCC. Those studies aimed at recognizing and targeting several signaling and molecular pathways that lead to cellular proliferation and tumor formation. In this review, we discussed the role of several agents found in natural...
    Published on: 15 Oct 2015
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  • Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

    Mosaad A. Abdel-Wahhab , Olivier Joubert , Aziza A. El-Nekeety , Hafiza A. Sharaf , Ferial M. Abu-Salem , Bertrand H. Rihn
    Aim: This study aimed to determine the composition of ethanol extract of jojoba seeds, and to evaluate its hepatoprotective effects in rats fed fumonisin B1 (FB1)-contaminated diet. Methods: Jojoba seeds were extracted in 95% ethanol, and the chemical composition was determined. Male rats were divided into six groups and treated for 8 weeks as follows: (1) Untreated control; (2) FB1-contaminated diet (80 mg/kg diet); (3) low dose (0.5 mg/kg b.w.) jojoba extract; (4) high dose (1.0 mg/kg b.w.) jojoba extract; (5) low dose jojoba extract plus FB1; and (6) high dose jojoba extract plus FB1....
    Published on: 9 Mar 2016
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  • Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were divided into 6 groups (8 rats each) and treated orally for 28 consecutive days as follows. Group 1: rats were given normal saline and used as controls; group 2: rats treated with CFME (200 mg/kg); group 3: rats treated with FSME (200 mg/kg); group 4: rats treated with AZA (25 mg/kg); and groups 5 and 6:...
    Published on: 15 Oct 2015
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  • Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with different concentrations of AFB1 and/or FB1 for 24 and 48 h with or without aqueous extract of A. hybridus. Results: AFB1 decreased the viability of cells after 24 and 48 h of exposure. EC50 values for AFB1 were 10.5 and 1.8 μmol/L for the two periods, respectively. When the 48 h exposure to...
    Published on: 15 Oct 2015
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  • Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w)...
    Published on: 15 Oct 2015
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