Most Viewed: Last TWO YEARS
  • Review|Open Access

    Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma

    Hanaa Ali Hassan , Nermin E. El-Gharib , Anmar F. Azhari
    Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in chronic liver disease. HCC associated with various risk factors including hepatitis B virus infection; hepatitis C virus infection; prolonged aflatoxin exposure; and alcoholic cirrhosis. Overall, one-third of cirrhosis patients will develop HCC during their life time. Also, chemical carcinogens cause... Read more
    Hepatoma Res 2016;2:216-23. | doi:10.20517/2394-5079.2016.12
    Published on: 5 Aug 2016  | Viewed:95484  | Downloaded:143
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Hepatoma Res 2015;1:109-10. | doi:10.4103/2394-5079.161332
    Published on: 15 Oct 2015  | Viewed:40759  | Downloaded:199
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  • Review|Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard
    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host cellular signaling processes can be detrimental to host cell physiology and can lead to virus-associated pathogenesis, including, for oncogenic viruses, cell transformation and cancer progression. Included among these oncogenic viruses is the hepatitis B virus (HBV). Despite the availability of an HBV... Read more
    Hepatoma Res 2016;2:163-86. | doi:10.20517/2394-5079.2016.05
    Published on: 1 Jul 2016  | Viewed:19453  | Downloaded:765
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  • Review|Open Access

    “PERISH” flowchart for selection of the patients with resectable hepatocellular carcinoma

    Cuneyt Kayaalp , H. Kerem Tolan , Mehmet Caglikulekci
    A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms/staging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always diffi culties in remembering and/or recalling the contents of the algorithms/staging systems. Moreover, most algorithms/staging systems do not include data about the extent of hepatectomy, intra-hepatic distribution of tumor(s), and technical feasibility of resection, all of which are vital in the surgeons’ decision-making process. Here, we aimed to present a... Read more
    Hepatoma Res 2015;1:165-70. | doi:10.4103/2394-5079.161329
    Published on: 15 Oct 2015  | Viewed:17513  | Downloaded:255
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  • Review|Open Access

    Physiological potential of cytokines and liver damages

    Fathia A. Mannaa , Khaled G. Abdel-Wahhab
    Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between tissues and the immune system; and participating in many physiological processes through their either anti-inflammatory or pro-inflammatory characteristics. Many cytokines have multiple cellular sources and targets, as well as many natural inducers and inhibitors. In pathophysiological conditions and... Read more
    Hepatoma Res 2016;2:131-43. | doi:10.20517/2394-5079.2015.58
    Published on: 1 Jun 2016  | Viewed:8997  | Downloaded:281
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were divided into 6 groups (8 rats each) and treated orally for 28 consecutive days as follows. Group 1: rats were given normal saline and used as controls; group 2: rats treated with CFME (200 mg/kg); group 3: rats treated with FSME (200 mg/kg); group 4: rats treated with AZA (25 mg/kg); and groups 5 and 6:... Read more
    Hepatoma Res 2015;1:125-35. | doi:10.4103/2394-5079.167375
    Published on: 15 Oct 2015  | Viewed:7981  | Downloaded:270
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse effects owing to chemotherapy and recurrence. The role of Curcumin as an adjuvant remedy is explored in this article. Curcumin stimulates apoptosis of cancer cells, acts as anti-proliferative agent, has anti-angiogenic action, prevents tumor invasiveness and metastasis and prevents recurrence. It also... Read more
    Hepatoma Res 2016;2:62-70. | doi:10.20517/2394-5079.2015.59
    Published on: 9 Mar 2016  | Viewed:7265  | Downloaded:309
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  • Review|Open Access

    Expectations for partial splenic arterial embolization simultaneous transcatheter arterial chemoembolization for hepatocellular carcinoma

    Toru Ishikawa
    Hepatocellular carcinoma (HCC) is frequently complicated by cirrhosis, and it is not unusual for treatment options to be limited as a result of pancytopenia due to hypersplenism. Partial splenic embolization (PSE) has been performed for thrombocytopenia resulting from hypersplenism. However, the safety and effi cacy of concurrent transcatheter arterial chemoembolization (TACE) with PSE for HCC remain unclear. Thrombocytopenia has been improved, and treatment continued using concurrent PSE. In addition, the hepatic functional reserve could be maintained even after treatment for HCC.... Read more
    Hepatoma Res 2015;1:155-8. | doi:10.4103/2394-5079.161284
    Published on: 15 Oct 2015  | Viewed:7026  | Downloaded:140
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  • Review|Open Access

    Microwave coagulation therapy of hepatocellular carcinoma

    Yong-Song Guan
    Microwave coagulation therapy (MCT) is a relatively new method of tumor ablation compared to other minimally invasive local therapies for hepatocellular carcinoma (HCC). It is a thermal ablation modality based on the application of heat, potentially leading to larger ablation zones. In recent years, there is a steady increase in the application of this modality to the treatment of HCC because it offers several advantages in the management of tumors larger than 3 cm in diameter. This article reviews the advances in MCT for the treatment of HCC in recent years including its brief history,... Read more
    Hepatoma Res 2015;1:159-64. | doi:10.4103/2394-5079.164648
    Published on: 15 Oct 2015  | Viewed:6817  | Downloaded:220
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w)... Read more
    Hepatoma Res 2015;1:147-54. | doi:10.4103/2394-5079.167376
    Published on: 15 Oct 2015  | Viewed:6307  | Downloaded:279
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with different concentrations of AFB1 and/or FB1 for 24 and 48 h with or without aqueous extract of A. hybridus. Results: AFB1 decreased the viability of cells after 24 and 48 h of exposure. EC50 values for AFB1 were 10.5 and 1.8 μmol/L for the two periods, respectively. When the 48 h exposure to... Read more
    Hepatoma Res 2015;1:136-46. | doi:10.4103/2394-5079.167377
    Published on: 15 Oct 2015  | Viewed:6208  | Downloaded:163
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in humans. Several researches have been reported numerous natural and phytochemical compounds that may counteract or prevent the hepatic injury and primary liver cancer. The conservative treatment of liver toxicity and HCC may face awkward challenges in chemotherapy such as therapeutic failure or... Read more
    Hepatoma Res 2015;1:111-8. | doi:10.4103/2394-5079.167378
    Published on: 15 Oct 2015  | Viewed:6005  | Downloaded:407
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor response. Several studies aimed at discovering more molecules for the management of HCC. Those studies aimed at recognizing and targeting several signaling and molecular pathways that lead to cellular proliferation and tumor formation. In this review, we discussed the role of several agents found in natural... Read more
    Hepatoma Res 2015;1:119-24. | doi:10.4103/2394-5079.167379
    Published on: 15 Oct 2015  | Viewed:5441  | Downloaded:293
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Hepatoma Res 2015;1:107-8. | doi:10.4103/2394-5079.161626
    Published on: 15 Oct 2015  | Viewed:4661  | Downloaded:114
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  • Review|Open Access

    Diet and nutrition therapy in pre-liver transplant patients

    Neha Bakshi , Kalyani Singh
    Malnutrition is universally prevalent among pre-liver transplantation patients. Malnutrition among cirrhotic patients had been associated to increased morbidity and mortality rates. Also, severely malnourished patients before the transplant surgery have a higher rate of complications and a decreased overall survival rate after liver transplantation. In light of the high incidence of malnutrition and associated complications, it is essential to initiate treatment as early as it is assessed. This review addresses the aetiologies of malnutrition and appropriate treatment strategies to correct... Read more
    Hepatoma Res 2016;2:207-15. | doi:10.20517/2394-5079.2016.02
    Published on: 5 Aug 2016  | Viewed:4369  | Downloaded:183
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  • Original Article|Open Access

    Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

    Jing Shen , Abby B. Siegel , Helen Remotti , Qiao Wang , Regina M. Santella
    Aim: Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate “HCC tumor type specific” and “tumor common” miRNA panels. Methods: The authors integrate and analyze clinical, etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas (TCGA) and HCC data from Columbia University Medical Center (CUMC). Results: Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues (over 2-fold changes) after Bonferroni... Read more
    Hepatoma Res 2016;2:151-62. | doi:10.20517/2394-5079.2015.66
    Published on: 1 Jun 2016  | Viewed:4072  | Downloaded:207
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  • Review|Open Access

    Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

    Alba Castán , Ylenia Navarro , Luis Sarría , Raquel Larrosa , Mario Serradilla , Alejandro Serrablo
    Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively rare. Compared with HCC arising in cirrhotic livers they have some quirks. HCC in healthy livers are large tumors at diagnosis, and are detected due to the onset of abdominal symptoms, outside of any scheduled monitoring program. In non-cirrhotic patients, HCC has the same appearance as the classic image of cirrhotic HCC substrate. The presence of capsule, extensive intratumoral necrosis and typical behavior in the dynamic study after administration of intravenous contrast are present in most of the non-cirrhotic... Read more
    Hepatoma Res 2017;3:1-17. | doi:10.20517/2394-5079.2015.62
    Published on: 12 Jan 2017  | Viewed:3823  | Downloaded:227
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise from diet-associated conditions such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Furthermore, toxins and nutrients such as mycotoxins and alcohol have an established role in the pathogenesis of chronic liver diseases, whereas specific diet patterns or foods have been... Read more
    Hepatoma Res 2016;2:53-61. | doi:10.20517/2394-5079.2015.64
    Published on: 9 Mar 2016  | Viewed:3656  | Downloaded:168
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  • Original Article|Open Access

    Surgical resection or radiofrequency ablation in the management of hepatocellular carcinoma: single center experience

    Wael Mansy , Morsi Mohammed , Sameh Saber
    Aim: The aim of this study is to prove or disprove the superiority of surgical resections over radiofrequency ablation (RFA) with respect to efficacy and safety. Methods: The study was conducted in Zagazig University Hospitals, which included 40 patients with hepatocellular carcinoma (HCC) during the period from November 2011 to December 2014, using either liver resection or RFA. Results: Hepatic resection was done in 20 patients (13 males, 7 females). Interventional RFA was done in 20 patients (12 males, 8 females). There was no in-hospital mortality after resection. One- and two-year... Read more
    Hepatoma Res 2016;2:92-7. | doi:10.4103/2394-5079.169642
    Published on: 1 Apr 2016  | Viewed:3293  | Downloaded:114
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  • Minireview|Open Access

    Updates on hepatorenal syndrome and strategies bridging to liver transplantation

    Chung Yeung Cheung , Kenneth S.H. Chok
    Hepatorenal syndrome is not an uncommon life-threatening complication arising from liver cirrhosis. The diagnostic criteria for this syndrome have been revised throughout the years, with recent revisions aimed at improving earlier diagnosis and treatment. Liver transplantation remains the only definitive treatment for hepatorenal syndrome. Due to the scarcity of liver grafts, many patients die waiting. This review focuses on the different strategies to bridge patients to liver transplantation and to improve the postoperative outcome. Read more
    Hepatoma Res 2017;3:67-72. | doi:10.20517/2394-5079.2016.48
    Published on: 12 Apr 2017  | Viewed:3230  | Downloaded:350
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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