Most Viewed: Last TWO YEARS
  • Review|Open Access

    Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma

    Hanaa Ali Hassan , Nermin E. El-Gharib , Anmar F. Azhari
    Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in chronic liver disease. HCC associated with various risk factors including hepatitis B virus infection; hepatitis C virus infection; prolonged aflatoxin exposure; and alcoholic cirrhosis. Overall, one-third of cirrhosis patients will develop HCC during their life time. Also, chemical carcinogens cause... Read more
    Hepatoma Res 2016;2:216-23. | doi:10.20517/2394-5079.2016.12
    Published on: 5 Aug 2016  | Viewed:96258  | Downloaded:148
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  • Review|Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard
    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host cellular signaling processes can be detrimental to host cell physiology and can lead to virus-associated pathogenesis, including, for oncogenic viruses, cell transformation and cancer progression. Included among these oncogenic viruses is the hepatitis B virus (HBV). Despite the availability of an HBV... Read more
    Hepatoma Res 2016;2:163-86. | doi:10.20517/2394-5079.2016.05
    Published on: 1 Jul 2016  | Viewed:24309  | Downloaded:855
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  • Review|Open Access

    Physiological potential of cytokines and liver damages

    Fathia A. Mannaa , Khaled G. Abdel-Wahhab
    Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between tissues and the immune system; and participating in many physiological processes through their either anti-inflammatory or pro-inflammatory characteristics. Many cytokines have multiple cellular sources and targets, as well as many natural inducers and inhibitors. In pathophysiological conditions and... Read more
    Hepatoma Res 2016;2:131-43. | doi:10.20517/2394-5079.2015.58
    Published on: 1 Jun 2016  | Viewed:10355  | Downloaded:306
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse effects owing to chemotherapy and recurrence. The role of Curcumin as an adjuvant remedy is explored in this article. Curcumin stimulates apoptosis of cancer cells, acts as anti-proliferative agent, has anti-angiogenic action, prevents tumor invasiveness and metastasis and prevents recurrence. It also... Read more
    Hepatoma Res 2016;2:62-70. | doi:10.20517/2394-5079.2015.59
    Published on: 9 Mar 2016  | Viewed:8309  | Downloaded:339
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  • Review|Open Access

    Diet and nutrition therapy in pre-liver transplant patients

    Neha Bakshi , Kalyani Singh
    Malnutrition is universally prevalent among pre-liver transplantation patients. Malnutrition among cirrhotic patients had been associated to increased morbidity and mortality rates. Also, severely malnourished patients before the transplant surgery have a higher rate of complications and a decreased overall survival rate after liver transplantation. In light of the high incidence of malnutrition and associated complications, it is essential to initiate treatment as early as it is assessed. This review addresses the aetiologies of malnutrition and appropriate treatment strategies to correct... Read more
    Hepatoma Res 2016;2:207-15. | doi:10.20517/2394-5079.2016.02
    Published on: 5 Aug 2016  | Viewed:5226  | Downloaded:208
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  • Review|Open Access

    Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

    Alba Castán , Ylenia Navarro , Luis Sarría , Raquel Larrosa , Mario Serradilla , Alejandro Serrablo
    Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively rare. Compared with HCC arising in cirrhotic livers they have some quirks. HCC in healthy livers are large tumors at diagnosis, and are detected due to the onset of abdominal symptoms, outside of any scheduled monitoring program. In non-cirrhotic patients, HCC has the same appearance as the classic image of cirrhotic HCC substrate. The presence of capsule, extensive intratumoral necrosis and typical behavior in the dynamic study after administration of intravenous contrast are present in most of the non-cirrhotic... Read more
    Hepatoma Res 2017;3:1-17. | doi:10.20517/2394-5079.2015.62
    Published on: 12 Jan 2017  | Viewed:4954  | Downloaded:253
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  • Original Article|Open Access

    Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

    Jing Shen , Abby B. Siegel , Helen Remotti , Qiao Wang , Regina M. Santella
    Aim: Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate “HCC tumor type specific” and “tumor common” miRNA panels. Methods: The authors integrate and analyze clinical, etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas (TCGA) and HCC data from Columbia University Medical Center (CUMC). Results: Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues (over 2-fold changes) after Bonferroni... Read more
    Hepatoma Res 2016;2:151-62. | doi:10.20517/2394-5079.2015.66
    Published on: 1 Jun 2016  | Viewed:4391  | Downloaded:220
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise from diet-associated conditions such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Furthermore, toxins and nutrients such as mycotoxins and alcohol have an established role in the pathogenesis of chronic liver diseases, whereas specific diet patterns or foods have been... Read more
    Hepatoma Res 2016;2:53-61. | doi:10.20517/2394-5079.2015.64
    Published on: 9 Mar 2016  | Viewed:3813  | Downloaded:175
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  • Minireview|Open Access

    Updates on hepatorenal syndrome and strategies bridging to liver transplantation

    Chung Yeung Cheung , Kenneth S.H. Chok
    Hepatorenal syndrome is not an uncommon life-threatening complication arising from liver cirrhosis. The diagnostic criteria for this syndrome have been revised throughout the years, with recent revisions aimed at improving earlier diagnosis and treatment. Liver transplantation remains the only definitive treatment for hepatorenal syndrome. Due to the scarcity of liver grafts, many patients die waiting. This review focuses on the different strategies to bridge patients to liver transplantation and to improve the postoperative outcome. Read more
    Hepatoma Res 2017;3:67-72. | doi:10.20517/2394-5079.2016.48
    Published on: 12 Apr 2017  | Viewed:3598  | Downloaded:378
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  • Original Article|Open Access

    Surgical resection or radiofrequency ablation in the management of hepatocellular carcinoma: single center experience

    Wael Mansy , Morsi Mohammed , Sameh Saber
    Aim: The aim of this study is to prove or disprove the superiority of surgical resections over radiofrequency ablation (RFA) with respect to efficacy and safety. Methods: The study was conducted in Zagazig University Hospitals, which included 40 patients with hepatocellular carcinoma (HCC) during the period from November 2011 to December 2014, using either liver resection or RFA. Results: Hepatic resection was done in 20 patients (13 males, 7 females). Interventional RFA was done in 20 patients (12 males, 8 females). There was no in-hospital mortality after resection. One- and two-year... Read more
    Hepatoma Res 2016;2:92-7. | doi:10.4103/2394-5079.169642
    Published on: 1 Apr 2016  | Viewed:3540  | Downloaded:118
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  • Review|Open Access

    Percutaneous hepatic perfusion with melphalan for unresectable liver metastasis

    Humair S. Quadri , Eden C. Payabyab , David J. Chen , William Figg , Marybeth S. Hughes
    Percutaneous hepatic perfusion (PHP) is an investigative technique for treating patients with diffuse unresectable metastatic liver disease. The technique has been clinically evaluated and shows great treatment potential for regional therapy to the liver. The advantage of PHP lies in its minimally invasive approach and ability to be repeated when compared to isolated hepatic perfusion. In a literature search, 135 publications were screened and 16 of these publications, including clinical trials and reviews, contributed to this review of PHP with melphalan. Melphalan is an alkylating agent... Read more
    Hepatoma Res 2016;2:197-202. | doi:10.20517/2394-5079.2016.24
    Published on: 13 Jul 2016  | Viewed:3268  | Downloaded:147
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  • Original Article|Open Access

    Hepatoprotective and antioxidant activity of Bombax ceiba flowers against carbon tetrachloride-induced hepatotoxicity in rats

    Manish M. Wanjari , Rachna Gangoria , Yadu Nandan Dey , Sudesh N. Gaidhani , Narendra K. Pandey , Ankush D. Jadhav
    Aim: The flowers of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of flowers of Bombax ceiba (BCAE) on experimentally induced hepatotoxicity in rats to substantiate its traditional use as hepatoprotective agent. Methods: Hepatotoxicity was induced in rats by carbon tetrachloride (CCl4) treatment; at the same time vehicle or BCAE (250 or 500 mg/kg) or silymarin (25 mg/kg) were administered daily orally for seven days. Hepatotoxicity was assessed by estimating the activities... Read more
    Hepatoma Res 2016;2:144-50. | doi:10.20517/2394-5079.2015.55
    Published on: 1 Jun 2016  | Viewed:3194  | Downloaded:411
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  • Review|Open Access

    Management of advanced hepatocellular carcinoma: review of current and potential therapies

    Asmaa Gomaa , Imam Waked
    Over the past few years, despite improvement in screening and diagnosis of hepatocellular carcinoma (HCC), advanced stage remains the most common presentation at diagnosis, with limited management options, especially options available to patients in limited resource countries. There is currently no effective systemic chemotherapy, targeted, or immunologic therapy for advanced stage HCC. Sorafenib is the only approved front-line molecular-targeted treatment,with slight survival benefit. Regorafenib has recently been approved as second line therapy for HCC after failure of sorafenib. Ongoing... Read more
    Hepatoma Res 2017;3:112-22. | doi:10.20517/2394-5079.2017.03
    Published on: 15 Jun 2017  | Viewed:2977  | Downloaded:442
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

    Mosaad A. Abdel-Wahhab , Olivier Joubert , Aziza A. El-Nekeety , Hafiza A. Sharaf , Ferial M. Abu-Salem , Bertrand H. Rihn
    Aim: This study aimed to determine the composition of ethanol extract of jojoba seeds, and to evaluate its hepatoprotective effects in rats fed fumonisin B1 (FB1)-contaminated diet. Methods: Jojoba seeds were extracted in 95% ethanol, and the chemical composition was determined. Male rats were divided into six groups and treated for 8 weeks as follows: (1) Untreated control; (2) FB1-contaminated diet (80 mg/kg diet); (3) low dose (0.5 mg/kg b.w.) jojoba extract; (4) high dose (1.0 mg/kg b.w.) jojoba extract; (5) low dose jojoba extract plus FB1; and (6) high dose jojoba extract plus FB1.... Read more
    Hepatoma Res 2016;2:78-86. | doi:10.4103/2394-5079.168078
    Published on: 9 Mar 2016  | Viewed:2964  | Downloaded:215
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  • Original Article|Open Access

    Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

    Mohamed Ahmed Samy Kohla , Om Kolsoum Al-Haddad , Ali Nada , Mohamed Al-Warraky , Manar Obada , Mohamed Amer , Sameera Ezzat , Ashraf Abou Gabal
    Aim: Epidermal growth factor (EGF) is a mitogen for hepatocyte grown in vitro, and its expression is up-regulated during liver regeneration. EGF also plays an important role in tumor initiation and progression. The goal of this study is to assess whether EGF is associated with advanced hepatocellular carcinoma (HCC) and also whether it is a predictive factor of shortened survival. Methods: Serum EGF levels were evaluated in a total of 151 subjects: 51 patients with unresectable HCC, (21 of them were eligible for transarterial chemoembolization (TACE) and serum EGF levels were measured... Read more
    Hepatoma Res 2016;2:18-25. | doi:10.4103/2394-5079.168959
    Published on: 15 Jan 2016  | Viewed:2926  | Downloaded:106
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  • Topic: Advances in the diagnosis and treatment of liver fibrosis|Open Access

    Advances in the diagnosis and treatment of liver fibrosis

    Jenny Yeuk-Ki Cheng , Grace Lai-Hung Wong
    Liver fibrosis is the center of diagnosis and management of essentially all chronic liver diseases. While liver biopsy examination still has a role in diagnosis and drug development, it is replaced by non-invasive assessments of liver biopsy in majority of the clinical scenarios. Radiological approaches, namely transient elastography, acoustic radiation force impulse imaging, shear wave elastography, magnetic resonance elastography provide accurate diagnosis of advanced fibrosis and cirrhosis. Serum test formulae based on common laboratory parameters or more specialized parameters including... Read more
    Hepatoma Res 2017;3:156-69. | doi:10.20517/2394-5079.2017.27
    Published on: 8 Aug 2017  | Viewed:2720  | Downloaded:181
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  • Original Article|Open Access

    Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study

    Hiroshi Yoshida , Hiroshi Makino , Tadashi Yokoyama , Hiroshi Maruyama , Atsushi Hirakata , Junji Ueda , Yasuhiro Mamada , Nobuhiko Taniai , Eiji Uchida
    Aim: The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the discrepancy between conventional and functional volumetry. Methods: The study group comprised 15 patients who underwent preoperative 3-dimensional (3D)-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT software before hepatectomy between July 2014 and August 2015. The diagnosis was... Read more
    Hepatoma Res 2016;2:187-92. | doi:10.20517/2394-5079.2016.06
    Published on: 1 Jul 2016  | Viewed:2652  | Downloaded:159
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  • Original Article|Open Access

    Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

    Adam Hauch , Carl Winkler , Eric Katz , Peter W. Lundberg , Mary Killackey , Anil S. Paramesh , Luis A. Balart , Nathan J. Shores , Martin Moehlen , Ward Miller , Douglas P. Slakey , Joseph F. Buell , Bob H. Saggi
    Aim: Portal vein thrombosis (PVT) in the liver transplant recipient poses many challenges. Unfortunately, the risk factors and effects on outcomes of PVT are not well-defined. Methods: This study analyzed the experience with PVT in liver transplant program from 2007 to 2013. This included the effectiveness of PVT diagnostics and its risk factors using logistical regression. The primary endpoints were Kaplan-Meir patient and graft survival. The secondary endpoints were the length of stay (LOS), transfusion rate, and overall morbidity. Independent predictors of survival were identified using... Read more
    Hepatoma Res 2016;2:36-41. | doi:10.4103/2394-5079.168070
    Published on: 29 Feb 2016  | Viewed:2421  | Downloaded:69
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  • Case Report|Open Access

    Nutrition profile of a liver transplant recipient

    Neha Bakshi , Kalyani Singh
    Malnutrition is almost universally present in patients undergoing liver transplantation. In this report, a male adult patient was followed from his pre-liver transplant phase until chronic post-transplant phase (3 months after the transplant). Improvement in nutrition status, quality of life, and performance status was seen from the pre-transplant to chronic post-transplant phase. Day to day nutrition monitoring and gradual increase in calorie and protein intake was seen in the acute post-transplant phase, but during pre- and chronic post-transplant phase, lack of nutrition support was... Read more
    Hepatoma Res 2016;2:98-102. | doi:10.4103/2394-5079.168958
    Published on: 1 Apr 2016  | Viewed:2389  | Downloaded:78
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  • Original Article|Open Access

    Is transarterial embolization a valuable treatment option for spontaneous rupture of hepatocellular carcinoma: experience from a tertiary care hospital of South-Asia

    Amna Subhan Butt , Saeed Hamid , Nazish Butt , Fatima Sharif , Tanveer Ul Haq , Wasim Jafri
    Aim: Transarterial embolization (TAE) has been found beneficial in treatment of ruptured Hepatocellular carcinoma (HCC) in earlier studies. So far no data is available from Pakistan. The aim of this study was to evaluate clinicopathological characteristics, outcomes of patients presented with spontaneously ruptured, unresectable HCC treated with or without TAE and to evaluate the factors associated with 30-day mortality. Methods: This was a cross sectional study. Patients ≥ 18 years old, presented with spontaneous rupture of unresectable HCC, were evaluated. The outcome measures were... Read more
    Hepatoma Res 2016;2:279-86. | doi:10.20517/2394-5079.2016.08
    Published on: 21 Oct 2016  | Viewed:2286  | Downloaded:135
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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