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Topic: Liver Cancer and Lifestyle: Evaluation, Nutritional Status, Dietary Habits and Prognosis

A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 30 Nov 2020

Guest Editor(s)

  • Manuela Merli, MD
    Department of Translational and Precision medicine, "Sapienza" University of Rome, Rome, Italy.

    Website | E-mail

Special Issue Introduction

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and a relevant health problem in many countries. The large majority of HCCs develop in patients with a diagnosis of liver cirrhosis. The incidence of HCC in these patients has been evaluated to be between 2% and 5% per year. The viral, alcoholic and metabolic origins of chronic liver disease have all been associated with the chance to develop HCC, so the treatment of HBV or HCV infections in geographic areas may progressively reduce the incidence rate of liver cancer in post viral patients. At present, a strict surveillance program with periodic liver ultrasonography is recommended in all cirrhotic patients to achieve early diagnosis and possible treatment. Malnutrition and Sarcopenia are widely recognized as associated complications in cirrhotic patients. Nutritional status, lifestyle and dietary habits have also been shown to influence patients’ outcome. No enough data are known in patients with HCC. Lifestyle, dietary intake and nutritional status (either malnutrition or overnutrition) may impact incidence, outcome, treatment complications and survival also in patients with a diagnosis of HCC. These parameters might be different according to the origin of liver disease, stage of HCC, and time from diagnosis to treatment applied. In this special issue we invite authors to contribute original data or review articles on the following topics:
1. Nutritional status and sarcopenia in patients with HCC.
2. Influence of nutritional status and/or sarcopenia on the incidence of HCC.
3. Nutritional status and/or Sarcopenia and survival in patients with HCC.
4. Nutritional status and/or sarcopenia and complications after treatment of HCC.
5. Nutritional status and/or sarcopenia and complications after liver transplantation for HCC.
6. Lifestyle and Diet as protective or risk factors of HCC (coffee, smoking, vitamins, exercise.).
7. Lifestyle and Diet for patients with HCC.
8. Energy expenditure and nutritional needs in patients with HCC.
9. Influence of nutritional status, lifestyle, dietary intake on recurrence of HCC.


1. Claudia Mandato  Department of Pediatrics, Children's Hospital Santobono-Pausilipon, Naples, Italy.
2. Daniella Miranda da Silva  Department of Nutrition, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
3. Yong-Bin Xiang  State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
4. Lemonica J.Koumbi  Hepatology and Gastroenterology Section, Department of Medicine, Imperial College London, London, UK.
5. Gianpaolo Vidili  Department of Clinical Medicine, University Hospital of Sassari, Sassari, Italy.
6. Giovanni Galati  Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
7. Gianluca Svegliati-Baroni  Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy.
8. Stefania Brozzetti  Department of Surgery "Pietro Valdoni", University of Rome "La Sapienza", Rome, Italy.
9. Fabio Farinati  Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
The list is arranged in no particular order and being updated.

Submission Deadline

30 Nov 2020

Submission Information

Articles of special issue are free of charge for article processing.
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Submission Deadline: 30 Nov 2020
Contacts: Victoria Lee, Assistant Editor,

Published Articles

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