Hot Keywords
non-alcoholic fatty liver disease epidemiology microenvironment nonalcoholic steatohepatitis transplantation cholangiocarcinoma direct-acting antiviral immunotherapy hepatitis B hepatitis C liver resection imaging cancer stem cell diagnosis gene cirrhosis biomarker recurrence

Topic: Role of Liver Stem Cells in the Tumorigenic Progression of Liver Cancer

A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 31 May 2020

Guest Editor(s)

  • Anne Corlu, PhD
    INSERM, University of Rennes, INRA, Institut NuMeCAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.

    Website | E-mail

  • Orlando Musso, MD, PhD
    INSERM, University of Rennes, INRA, Institut NuMeCAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.

    Website | E-mail

Special Issue Introduction

Hepatocellular carcinoma (HCC) is the leading cause of death in patients with severe liver fibrosis. Over 80% of HCCs arise in a background of liver fibrosis resulting from chronic viral infections, alcohol abuse, as well as exposure to aflatoxin B, genetic diseases and metabolic syndrome. The only potentially curative treatment for a minority of selected cases is liver transplantation. Recently, encouraging therapeutic results have been reported with protocols that apply one or more of the following methods: partial hepatectomy, tumor ablation, chemoembolization, selective internal radiation therapy, as well as systemic approaches with multikinase inhibitors and targeting of anti-tumor immunity. Despite this wealth of therapeutic strategies, treatment resistance and hence cancer progression result from co-evolution of an ecosystem composed of cancer cells themselves and their microenvironment. Evolving interactions within this ecosystem progressively select the fittest cancer stem cells. Stemness displays a diversity of phenotypes involving, but not limited to, cell plasticity, metabolic adaptations, drug detoxification, immune escape and quiescence, which converge to generate pluripotency. Cancer progression through the emergence of pluripotency ultimately fosters the survival of the fittest cancer cells. In this special issue, the diversity of phenotypes and pathways leading to stemness in hepatocellular carcinomas is reviewed.


1. Kun Guo   Dalian Med University, China.
2. Giuseppe Carruba   Division of Research and Internationalization, ARNAS-Civico Di Cristina e Benfratelli, Palermo, Italy.
3. Raymond Wu   Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
4. German L Velez-Reyes   Department of Biology, Natural Sciences Faculty, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico.
5. Kazushige Yokoyama & Kungkai Kuo   School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.
6. Claude Caron De-Fromentel   Cancer Research Centre of Lyon, INSERM, CNRS, Université Claude Bernard Lyon1, Centre Léon Bérard, Lyon, France.
7. Rosa Maria Pascale   Department of Clinical, Surgery and Experimental Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy.
8. Orlando Musso   INSERM, Univ Rennes, INRA, Institut NuMeCAN (Nutrition Metabolisms and Cancer), F-35000 Rennes, France.
9. Yong Yang   Center for New Drug Safety Eva­luation and Research, China Pharmaceutical University, Nanjing, China.
10. Nai Yang Fu   Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.
11. Pascal Pineau   Unité 'Organisation Nucléaire et Oncogenèse', INSERM U993, Institut Pasteur, Paris, France.
The list is arranged in no particular order and to be updated.

Submission Deadline

31 May 2020

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
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Submission Deadline: 31 May 2020
Contacts: Delphine Wong, Assistant Editor,

Published Articles

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