Topic: The Interplay between Direct-Acting Antivirals and Hepatocellular Carcinoma in Chronic Hepatitis C

A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 30 Nov 2019

Guest Editor(s)

  • Ming-Lung Yu, MD, PhD
    Professor, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University, Kaohsiung, Taiwan.

    Website | E-mail

Special Issue Introduction

Chronic hepatitis C (CHC) infection is one of the major etiologies of hepatocellular carcinoma (HCC). As with the observations in the interferon era, treating patients with directly acting antivirals significantly reduces HCC risk. However, the risk ratio reduction may be more limited in patients who already possess decompensated liver cirrhosis. In terms of HCC recurrence, it has been suggested HCC may recur more frequently and aggressively after DAA intervention. The difficulty of performing a prospective study comparing to non-treatment cohort may render an inconclusive results. The issue of washout period between curative HCC treatment and initiating DAA treatment may also determine the interpreting the outcomes. With more evidence emerge, the HCV eradication by DAA should not have a negative impact on HCC recurrence.
From the other perspective, whether the presence of active HCC would compromise DAA treatment efficacy remains an area of uncertainty. The discrepant results may arise from diverse patient characteristics and treatment regimens. The long-term survival benefit of HCV eradication in patients with active HCC remains to be studied. In this issue, the interaction between DAA and HCC will be reviewed.


Raymond T. Chung&Stephanie Marie Rutledge  Massachusetts General Hospital, Harvard Medical School, Boston, USA (Published)
Suna Yapali  Division of Gastroenterology and Hepatology, Acibadem Mehmet Ali Aydinlar University, Turkey
João Marcello de Araujo Neto  Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Warren N. Schmidt  University of Iowa Carver College of Medicine, Iowa City, USA
Bashar Attar  Cook County Health and Hospitals System, Chicago, USA
Tathagata Choudhuri  Visva-Bharati University, Santiniketan, India
George Lau  The University of Hong Kong, Pokfulam, Hong Kong
Mocan Tudor&Zeno Sparchez  Institute for Gastroenterology and Hepatology, Cluj-Napoca, Romania
Ming Yang  Beijing Tsinghua Changgung Hospital, Beijing, China
Mamuka Zakalashvili  Medical Center Mrcheveli, Tbilisi, Georgia
Mario Pirisi  Università del Piemonte Orientale, Novara, Italy
Stefano Brillanti  Alma Mater Studiorum Università di Bologna, Bologna, Italy
Syed Muhammad Ali Shah  Nawaz Sharif Medical College, University of Gujrat, Gujrat, Pakistan
Tatsuo Kanda  Nihon University School of Medicine, Tokyo, Japan
Mohamed Kohla  Menoufia University, Shebin El Kom, Egypt
Sandra Ciesek  Institute of Medical Virology, University Hospital Frankfurt, Frankfurt, Germany
Mohamed El Kassas  Helwan University, Cairo, Egypt
Wen-Juei Jeng&Wei Teng  Chang Gung Memorial Hospital, Linkou branch, Taiwan
Moutaz F.M. Derbala  Hamad Medical Corporation, Doha, Qatar
Chia-Yen Dai  Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
Zahari A. Krastev  Sveti Ivan Rilski hospital, Sofia, Bulgaria (Submitted, under processing)
Anna Maria Spera  Università degli Studi di Napoli Federico II, Naples, Italy
Hasmik Ghazinian  Nork Clinical Hospital of Infectious Diseases, Yerevan, Armenia
Jung Hyun Kwon&Sun Hong Yoo  The Catholic University of Korea, Seoul, South Korea
Zainab A. Zakaria  Heliopolis University for Sustainable Development, Heliopolis, Egypt
Yi-Hao Yen  Chang Gung University College of Medicine, Taoyuan, Taiwan
Alma Minerva Perez Rios  Department of Infectious Disease, Hospital General Regional 110 IMSS Guadalajara, Jalisco, Mexico
Donald Jensen&Sheila Eswaran  Rush University Medical Center, Chicago, USA
Hesham El-Sayed  Suez Canal University, Ismalia, Egypt
Juan Socorro Armendariz-Borunda, Christian Monroy&Laura Sanchez  Tecnologico de Monterrey, Monterrey, Mexico
Pin-Nan Cheng  National Cheng Kung University Hospital, Tainan, Taiwan
Erica Villa  Università degli Studi di Modena e Reggio Emilia, Modena, Italy
Mohammad Umar  Riphah Institute of Pharmaceutical Sciences, Islamabad, Pakistan
Pisit Tangkijvanich  Chulalongkorn University, Bangkok, Thailand
David E Bernstein&Tai-Ping Lee  Hofstra Northwell School of Medicine, Hempstead, USA
The list is arranged in no particular order and being updated.

Submission Deadline

30 Nov 2019

Submission Information

Articles of special issue are free of charge for article processing.
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Submission Deadline: 30 Nov 2019
Contacts: Haidi Ding, Assistant Editor,

Published Articles