Special Issue
Topic: Molecular Pathogenesis and Drivers of Cholangiocarcinoma
A Special Issue of Hepatoma Research
ISSN 2454-2520 (Online) 2394-5079 (Print)
Submission deadline: 30 Dec 2022
Guest Editor(s)
Luca Fabris, MD, PhD
Associate Professor of Gastroenterology, Department of Molecular Medicine, University of Padova, Padua, Italy.
Special Issue Introduction
Development and progression of cholangiocarcinoma (CCA) is sustained by an intricate and heterogeneous process that include the deregulation of signalling pathways, related to development and liver repair, which control cell homeostasis and survival, chronic inflammation, fibrosis, angiogenesis and immune cell response. A complex interplay of extracellular ligands (pro-inflammatory cytokines and chemokines, growth factors, matrix components among others) released by a multitude of cell types which populate a dense tumour microenvironment represents a defining feature of CCA. Moreover, thanks to the advent of integrative genomic studies, it is emerging that distinctive genomic alteration affecting cell cycle regulation, DNA damage and repair, kinase signalling and morphogens can be differently found in the intrahepatic and extrahepatic variants of CCA (iCCA, eCCA). Moreover, epigenetics, including deregulation of methylation, histone modifications, aberrant expression of non-coding RNAs and post-translation modifications of proteins, was shown to play a key role in either the initiation or progression of CCA. Acquisition of a cancer stem cell-like phenotype may also contribute to the wide tumour heterogeneity and resistance to anti-cancer drugs, which typically characterize CCA.
In this Special Issue of Hepatoma Research, major experts in the subject will discuss the intricate landscape of genetic and epigenetic perturbations, multicellular communications within the tumour microenvironment, molecular effectors and related signalling, which incite the malignant transformation and the highly invasive behaviour of this still enigmatic type of cancer.
Potential topics include, but are not limited to the followings:
1. Genomic alterations in iCCA
2. Genomic alterations in eCCA
3. Epigenetic alterations and post-translational modifications in CCAs
4. Signalling and molecular networks related to development and inflammation involved in CCA initiation and progression
5. Stemness and plasticity in CCA development and progression
6. Tumor microenvironment highlighting CAF, including different subpopulations
7. Tumor microenvironment highlighting TAM and immune cells
8. Tumor microenvironment highlighting angiogenesis
9. Tumor microenvironment highlighting fibrosis and ECM proteins
10. Chemoresistance and CCA progression
In this Special Issue of Hepatoma Research, major experts in the subject will discuss the intricate landscape of genetic and epigenetic perturbations, multicellular communications within the tumour microenvironment, molecular effectors and related signalling, which incite the malignant transformation and the highly invasive behaviour of this still enigmatic type of cancer.
Potential topics include, but are not limited to the followings:
1. Genomic alterations in iCCA
2. Genomic alterations in eCCA
3. Epigenetic alterations and post-translational modifications in CCAs
4. Signalling and molecular networks related to development and inflammation involved in CCA initiation and progression
5. Stemness and plasticity in CCA development and progression
6. Tumor microenvironment highlighting CAF, including different subpopulations
7. Tumor microenvironment highlighting TAM and immune cells
8. Tumor microenvironment highlighting angiogenesis
9. Tumor microenvironment highlighting fibrosis and ECM proteins
10. Chemoresistance and CCA progression
Submission Deadline
30 Dec 2022
Submission Information
For Author Instructions, please refer to https://www.oaepublish.com/hr/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=hr&SpecialIssueId=hr220512
Submission Deadline: 30 Dec 2022
Contacts: Delphine Wong, Assistant Editor, editor_delphine@hrjournal.net
Published Articles
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