- Daniel Wai Hung Ho, PhD
State Key Laboratory of Liver Research, the University of Hong Kong, Hong Kong, China.
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Special Issue Introduction
Liver cancer is a common fatal human malignancy. It is known to have different etiological risk factors such as hepatitis virus infection, alcohol consumption, and obesity. Notably, it has a high degree of heterogeneity, both intra- and inter-tumorally. Traditional analytic strategies have their inherent limitations, and the emergence of single-cell sequencing allows comprehensive investigations at unprecedented resolution.
Given the merits of single-cell sequencing approaches in the study of liver cancer, there are increasing numbers of studies adopting this method. After obtaining the single-cell data, various cellular and molecular landscapes can be delineated. In this special issue, we focus on the single-cell investigations of liver cancer, ranging from basic to translational perspectives.
This special issue calls for original or review manuscripts, perspectives, opinions and commentary, etc. on different aspects, including but not limited to:
1. Intra-tumoral and inter-tumoral heterogeneity of liver cancer
2. Transcriptomic, genetic/genomic, and epigenomic landscape of liver cancer
3. Cellular landscape and the underlying interactions between cells within the tumor microenvironment
4. Lineage hierarchy of liver cancer stem cell
5. Mechanistic exploration using single-cell sequencing
6. Biomarker discovery for treatment, diagnosis, and prognosis
Submission Deadline 1 Aug 2022