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Topic: Single-cell RNA Sequencing in Hepatocellular Carcinoma

A special issue of Hepatoma Research

ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)

Submission deadline: 1 Aug 2022

Guest Editor(s)

  • Daniel Wai Hung Ho, PhD

    State Key Laboratory of Liver Research, the University of Hong Kong, Hong Kong, China.

    Website | E-mail

Special Issue Introduction

Liver cancer is a common fatal human malignancy. It is known to have different etiological risk factors such as hepatitis virus infection, alcohol consumption, and obesity. Notably, it has a high degree of heterogeneity, both intra- and inter-tumorally. Traditional analytic strategies have their inherent limitations, and the emergence of single-cell sequencing allows comprehensive investigations at unprecedented resolution.

Given the merits of single-cell sequencing approaches in the study of liver cancer, there are increasing numbers of studies adopting this method. After obtaining the single-cell data, various cellular and molecular landscapes can be delineated. In this special issue, we focus on the single-cell investigations of liver cancer, ranging from basic to translational perspectives.

This special issue calls for original or review manuscripts, perspectives, opinions and commentary, etc. on different aspects, including but not limited to:
1. Intra-tumoral and inter-tumoral heterogeneity of liver cancer
2. Transcriptomic, genetic/genomic, and epigenomic landscape of liver cancer
3. Cellular landscape and the underlying interactions between cells within the tumor microenvironment
4. Lineage hierarchy of liver cancer stem cell
5. Mechanistic exploration using single-cell sequencing
6. Biomarker discovery for treatment, diagnosis, and prognosis

Submission Deadline

1 Aug 2022

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
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Submission Deadline: 1 Aug 2022
Contacts: Paula Dong, Assistant Editor,

Published Articles

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