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Hepatoma Res 2021;7:[Accepted].10.20517/2394-5079.2021.26@The Author(s) 2021
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A practical approach to pediatric liver transplantation in hepatoblastoma and hepatocellular carcinoma

Correspondence Address: Dr. Ana M. Calinescu, Division of Pediatric Surgery, University Center of Pediatric Surgery of Western Switzerland, Geneva University Hospitals, 6 Rue Willy Donze, Geneva 1205, Switzerland. E-mail :


© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (, which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


Progressively, as chemotherapy has become more effective, more children with liver malignancies are amenable to liver transplantation, and indications have expanded from a limited range of cases (mostly hepatoblastoma) to a range of other unresectable malignant liver tumours; as a result, more children with hepatocellular carcinoma are also now proposed to transplantation, even and often outside the Milan’s criteria, for a cure. More, recent series highlighted that patient and graft survival after transplantation for hepatoblastoma and hepatocellular carcinoma have improved in the last decade. Although consensus has not yet been reached about transplantation as a possible cure for other tumour types than hepatoblastoma and hepatocellular carcinoma, liver transplantation, generally speaking, has become an important pillar in the management of pediatric liver malignancies. Remaining limitations and inquiries relate to patient selection (in term of selection criteria considering the risk of recurrence), the role and usefulness of chemotherapy after transplantation, or the best immunosuppression strategy to both protecting renal function and improving outcome. Though some prospective studies are on the way regarding these aspects, more studies are necessary to explore this rapidly changing aspect of care.

Cite This Article

Calinescu AM, Héry G, de Ville de Goyet J, Branchereau S. A practical approach to pediatric liver transplantation in hepatoblastoma and hepatocellular carcinoma. Hepatoma Res 2021;7:[Accept].

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