Hot Keywords
non-alcoholic fatty liver disease epidemiology microenvironment nonalcoholic steatohepatitis transplantation cholangiocarcinoma direct-acting antiviral immunotherapy hepatitis B hepatitis C liver resection imaging cancer stem cell diagnosis gene cirrhosis biomarker recurrence

Hepatoma Res 2015;1:49.10.4103/2394-5079.159519
Open AccessEditorial

The evolving role of laparoscopic ablation

Tulane Transplant Institute, Tulane University, New Orleans, LA 70118, USA

Correspondence Address: Prof. Joseph F. Buell, Tulane Transplant Institute, Tulane University, New Orleans, LA 70118, USA. E-mail:

    Views:6814 | Downloads:335 | Cited:0 | Comments:0 | :0

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License (, which allows others to remix, tweak and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

    In the last two decades, the etiology of hepatocellular cancer has shifted from hepatitis B to hepatitis C with the incidence of nonalcoholic steatohepatitis (NASH) rising dramatically. This sudden rise in NASH and newly diagnosed cases of hepatocellular cancer may represent the tip of an epidemic. Current recommendations for patients with chronic hepatitis B or hepatitis C infections should be screened with routine use of ultrasound. Despite this Surveillance, Epidemiology, and End Results, data would suggest that the average size of newly diagnosed hepatocellular cancer is beyond the Milan criteria at the time of diagnosis. In the setting of fatty liver disease and NASH, an early serologic diagnosis is not evident.

    Significant limitations already exist in the availability of liver allografts for liver transplantation. This constraint in organ availability necessitates improved loco-regional therapies. Open and laparoscopic liver resection have been traditionally limited to Child’s A and early B cirrhotics. In recent years, more sophisticated evaluations have been proposed including transjugular pressure gradients and vital dye excretion. With the unfortunate limitations in transplantation and resection, ablation has become the mainstay of therapy. Chemoembolization and later radioembolization with yttrium have been most frequently employed a technique for ablation.

    Surgical ablation initially was hampered by technologic limitations. This included liver fracture and profuse bleeding associated with cryotherapy, and prolonged treatment times and patient hyperthermia with radiofrequency ablation. Radiofrequency ablation with its slow thermal evolution was susceptible to heat sink and inadequate ablations. The most recent evolution in ablation was the development of microwave ablation. Microwave catheters were designed to decrease treatment times and overcome thermal sinks.

    Despite the improved treatment capacity, microwave catheters create more oblong ablation cavities. The treatment areas are not exact with potential marginal recurrence from inadequate ablations. Next generation microwave catheters are being designed to generate uniform ablation defects. Alternative treatment options include advanced imaging registration and catheter placement. In this current issue of Hepatoma Research, the role of laparoscopic ablation is discussed and evaluated. Additional articles discuss the mechanism and role of sorafenib in the adjuvant and primary treatment of unresectable hepatocellular cancer.

    In the next decade, the number and incidence of unresectable and untransplantable liver cancers will increase dramatically. This necessitates improvements in loco-regional control including ablation technologies and adjuvant systemic therapies.

    Financial support and sponsorship


    Conflicts of interest

    There are no conflicts of interest.

    Cite This Article

    Buell JF. The evolving role of laparoscopic ablation. Hepatoma Res 2015;1:49 .



    Download and Bookmark


    Download PDF Add to Bookmark

    Share This Article

    Article Access Statistics

    Full-Text Views Each Month

    PDF Downloads Each Month


    Comments must be written in English. Spam, offensive content, impersonation, and private information will not be permitted. If any comment is reported and identified as inappropriate content by OAE staff, the comment will be removed without notice. If you have any queries or need any help, please contact us at

    © 2016-2021 OAE Publishing Inc., except certain content provided by third parties