Topic: Advances in Minimally Invasive Cirrhotic Surgery

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A special issue of Hepatoma Research  (Print ISSN:2394-5079; Online ISSN:2454-2520).

Deadline for manuscript submissions: 8 Jul 2016

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Guest Editor(s)

  • Giulio Belli, MD
    General and HPB Surgery, Loreto Nuovo Hospital, 80121 Naples, Italy.


Special Issue Introduction:

Hepatocellular carcinoma (HCC) is the sixth most common type of cancer worldwide and the third leading cause of cancer-related death. It is the most common primary liver cancer and its incidence increases when associated with the development of cirrhosis. Liver resection is a curative therapy, when liver transplantation due to the patient age and alcohol abuse, associated diseases, and shortage of donors, is not feasible. During the last decades, progress in preoperative patient assessment, refinement of the indications for resection, improved surgical technique, and the development of new surgical devices have greatly enhanced the safety of open hepatectomy in normal and even in cirrhotic liver. In fact, the role of the mininvasive approach in liver surgery continues to increase, and many types of liver resections, even in cirrhotic liver, including major hepatectomies, are now performed laparoscopically in specialized centers. It is now clear that laparoscopic liver resection for HCC on cirrhotic liver has better short results when compared to an open approach. In fact, despite its technical challenges, reduced operative blood loss, fewer early postoperative complications, such as postoperative ascites, lower analgesic drug requirements, and shorter hospital stay are the clear advantages of the laparoscopic approach. Therefore, laparoscopic resection of HCC in cirrhotic liver is not only feasible and safe in selected patients with excellent short-term results, but achieves not inferior long-term survival end recurrence rates compared with open surgery when stratified for tumor characteristics known to be related to survival of outcome.
In this special issue of Hepatoma Research focusing on “Advances in Minimally Invasive Cirrhotic Surgery”, the challenges of this rapidly developing field are addressed. Each of the contributors has referred specific aspects of their experienced area, discussing its limits but also its advantages. They have also discussed their technique and results.

Submission Information:

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Submission Deadline: 8 Jul 2016
Contacts: Siqi Li, Assistant Editor,

Published Articles Download All Articles
  • Laparoscopic liver resection for hepatocellular carcinoma in patients with cirrhosis

    Jai Young Cho , Ho-Seong Han
    Hepatocellular carcinoma (HCC) is a common malignant tumor and many cases occur in patients with liver cirrhosis. Although liver transplantation is the most effective treatment option, hepatectomy is still the first curative treatment option because liver transplantation is limited by the donors and high cost. In recent years, laparoscopic liver resection (LLR) has increasingly been performed... Read more
    Hepatoma Res 2016;2:259-63. | doi:10.20517/2394-5079.2016.13
    Published on: 30 Sep 2016  | Viewed:1978  | Downloaded:166
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  • Liver resection for hepatocellular carcinoma within a fast-track management: a propensity-score matched analysis between open and laparoscopic approach

    Francesca Ratti , Federica Cipriani , Raffaella Reineke , Marco Catena , Michele Paganelli , Luigi Beretta , Luca Aldrighetti
    Aim: The study was designed to assess the implications of enhanced recovery after surgery (ERAS) approach in patients submitted to open liver resection for hepatocellular carcinoma (HCC) comparing their short term outcome with patients treated by laparoscopic approach, in a case-matched design. Methods: The open-group (n = 60) was matched in a ratio of 1:1 with patients undergoing laparoscopic... Read more
    Hepatoma Res 2016;2:271-8. | doi:10.20517/2394-5079.2016.20
    Published on: 30 Sep 2016  | Viewed:1939  | Downloaded:139
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  • Laparoscopic resection of hepatocellular carcinoma in patients with and without cirrhosis: the Brisbane experience

    Daniel J. Kilburn , Universe Leung , David J. Cavallucci , Cassandra Jeavons , Mehan Siriwardhane , Richard Bryant , Thomas R. O’Rourke , Shinn Yeung , Nicholas A. O’Rourke
    Aim: Laparoscopic liver resection for hepatocellular carcinoma (HCC) is increasingly common around the world. There may be significant advantages over open resections. However, due to technical difficulties, they are performed in few centers with expertise in liver and advanced laparoscopic surgery. In this study the authors summarize the experience to date. Methods: A retrospective analysis of... Read more
    Hepatoma Res 2016;2:264-70. | doi:10.20517/2394-5079.2016.29
    Published on: 30 Sep 2016  | Viewed:2674  | Downloaded:172
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  • Case report of the fourth laparoscopic liver resection and review of repeat laparoscopic resection for recurrent hepatocellular carcinoma in cirrhotic liver

    Zenichi Morise , Masashi Isetani , Norihiko Kawabe Norihiko Kawabe , Hirokazu Tomishige , Hidetoshi Nagata , Satoshi Arakawa , Masahiro Ikeda , Kenshiro Kamio
    A 73-year-old woman with liver cirrhosis caused by hepatitis C virus (HCV) underwent treatment of three hepatocellular carcinomas (HCCs) in liver segment 4, following three previous laparoscopic liver resections (LLRs) over 73 months. Contrast-enhanced computed tomography showed three 0.5-1.2 cm HCCs deep within the portal territories of subsegments 4a and 4b. The patient underwent laparoscopic... Read more
    Hepatoma Res 2016;2:253-8. | doi:10.20517/2394-5079.2016.09
    Published on: 19 Sep 2016  | Viewed:3868  | Downloaded:163
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  • Indications and technique for laparoscopic liver resection in patients with hepatocellular carcinoma and liver cirrhosis

    Yuichiro Otsuka , Masaru Tsichiya , Toshio Katagiri , Yoshihisa Kubota , Jun Ishii , Tetsuya Maeda , Hironori Kaneko
    Liver resection is the preferred initial treatment option for solitary or limited multifocal hepatocellular carcinoma (HCC). However, because of the characteristics of HCC, including its high recurrence rate and the frequent presence of chronic hepatitis and cirrhosis, both curability and invasiveness must be considered when selecting a treatment for HCC. Laparoscopic liver resection (LLR) is... Read more
    Hepatoma Res 2016;2:241-7. | doi:10.20517/2394-5079.2016.11
    Published on: 19 Sep 2016  | Viewed:3014  | Downloaded:233
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  • Introduction of the special issue: “Advances in Minimally Invasive Cirrhotic Surgery”

    Giulio Belli
    Hepatoma Res 2016;2:239-40. | doi:10.20517/2394-5079.2016.16
    Published on: 19 Sep 2016  | Viewed:1297  | Downloaded:119
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  • Laparoscopic liver resection in the cirrhotic patient

    Ben Robichaux , Jesse Sulzer , Joseph F. Buell
    Aim: The adoption of laparoscopic liver resection has been expansive in the last 2 decades with the exception of cirrhotic patients. The current study examines the outcomes of our cirrhotic resections to determine the potential limitations of this technique. Methods: Retrospective analysis of 114 cirrhotic patients. Seventy-five (65.8%) laparoscopic resections were compared to 39 open... Read more
    Hepatoma Res 2016;2:248-52. | doi:10.20517/2394-5079.2016.23
    Published on: 19 Sep 2016  | Viewed:2352  | Downloaded:135
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Hepatoma Research ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)
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