Topic: Molecular Mechanism of Hepatocellular Carcinoma

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A special issue of Hepatoma Research  (Print ISSN:2394-5079; Online ISSN:2454-2520).

Deadline for manuscript submissions: 26 Apr 2018

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Guest Editor(s)

  • Seung Kew Yoon, MD
    Cancer Hospital, Seoul St. Mary's hospital, The Catholic University of Korea, Seoul, South Korea.

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Special Issue Introduction:

It is generally accepted that hepatocarcinogenesis is a very complex process that occurs through a multistep biological process during malignant transformation of normal hepatocytes in which various factors including genetic and epigenetic alterations are involved. Specifically, recent advances of NGS technologies have allowed the researchers to more profound understand the molecular mechanism of HCC, which have contributed to develop target therapy for cancers by identifying gene and associated signals involved in carcinogenesis and tumor progression. However, it is very difficult to completely treat advanced HCC because most advanced HCC are accompanied with poor liver function by liver cirrhosis. Surgical approaches including resection and liver transplantation in these cases are not available and so molecular target therapy combined with immunotherapy has been an alternative strategy to prolong patients’ survival. To this end, further investigation of molecular pathway through various approaches in hepatocarcinogenesis and tumor progression is indispensable. In this session, we discuss recent advances in the molecular mechanism of HCC in various aspects and apply it to develop new molecular target therapy for HCC.

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://hrjournal.net/pages/view/author_instructions
For Online Submission, please login at http://www.editorialmanager.com/hres/default.aspx
Submission Deadline: 26 Apr 2018
Contacts: Siqi Li, Assistant Editor, editor001@hrjournal.net

Published Articles Download All Articles
  • Mechanisms and clinical behavior of hepatocellular carcinoma in HBV and HCV infection and alcoholic and non-alcoholic fatty liver disease

    Riccardo Nevola , Luca Rinaldi , Mauro Giordano , Aldo Marrone , Luigi Elio Adinolfi
    Hepatocellular carcinoma (HCC) is the main tumor of the liver and is the sixth most frequently diagnosed tumor in the world. It is the evolution of chronic hepatic injury secondary to different etiologies. Chronic hepatitis B virus and hepatitis C virus infection, chronic alcoholic hepatitis, as well as non-alcoholic fatty liver disease are the most common causes behind the development of HCC.... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:55. | doi:10.20517/2394-5079.2018.38
    Published on: 20 Sep 2018  | Viewed:385  | Downloaded:33
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  • The fibroblast growth factor receptor pathway in hepatocellular carcinoma

    Joycelyn Jie Xin Lee , Su Pin Choo
    Hepatocellular carcinoma is the third most common cause of cancer-related death globally and portends a poor prognosis. The fibroblast growth factor receptor (FGFR) pathway is increasingly acknowledged to play a role in the pathogenesis of hepatocellular carcinoma (HCC) and is postulated to be upregulated as a mechanism of resistance to anti-VEGF treatment. We attempt to review the importance... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:52. | doi:10.20517/2394-5079.2018.42
    Published on: 13 Sep 2018  | Viewed:363  | Downloaded:34
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  • Molecular mechanism of hepatocellular carcinoma

    Seung Kew Yoon
    Development of hepatocellular carcinoma (HCC) is very complex and occurs through a multistep biological process of malignant transformation of normal hepatocytes in which various factors, including genetic and epigenetic alterations, regulation of oxidative stress, inflammation, and immunity are involved. To date, numerous studies have described the molecular pathogenesis of HCC, but the... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:42. | doi:10.20517/2394-5079.2018.23
    Published on: 8 Aug 2018  | Viewed:934  | Downloaded:169
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  • Oxidative stress and hepatocarcinogenesis

    Ying Fu , Fung-Lung Chung
    Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. There are two major challenges for HCC, the first being that early detection is generally not applicable, and secondly, it is usually fatal within several months after diagnosis. HCC is an inflammation-induced cancer. It is known that chronic inflammation leads to oxidative/nitrosative stress and... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:39. | doi:10.20517/2394-5079.2018.29
    Published on: 1 Aug 2018  | Viewed:1091  | Downloaded:163
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  • Aberrant pre-mRNA splicing regulation in the development of hepatocellular carcinoma

    Supriya Sen
    Alternative splicing is a highly regulated process that plays a critical role in diversification of the transcriptome and proteome in the cell. Several diseases, including different types of cancers, have been associated with aberrant regulation of alternative splicing. Thus, correcting alternative splicing is an attractive strategy to restore normal cell physiology in patients with cancer... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:37. | doi:10.20517/2394-5079.2018.39
    Published on: 18 Jul 2018  | Viewed:447  | Downloaded:18
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  • [18F]FDG PET imaging evaluation on non-alcoholic fatty liver disease and hepatocellular carcinoma model treated with sorafenib

    Fernando Gomes de Barros Costa , José Tadeu Stefano , Daniele de Paula Faria , Caio de Souza Levy , Maria Cristina Chammas , Camila de Godoi Carneiro , Isabel Veloso Alves Pereira , Bruno Cogliati , Flair José Carrilho , Claudia P. Oliveira
    Aim: Evaluate the effect of sorafenib in a rat model of non-alcoholic fatty liver disease (NAFLD) related to hepatocellular carcinoma (HCC) by quantifying the correlation between changes in glucose metabolism on PET imaging and degree of tumor differentiation. Methods: NAFLD related HCC was induced by the combination of high fat and choline deficient diet with diethylnitrosamine (100 mg/L) for... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:35. | doi:10.20517/2394-5079.2018.06
    Published on: 12 Jul 2018  | Viewed:541  | Downloaded:29
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  • Somatostatin in hepatocellular carcinoma: experimental and therapeutic implications

    Elias Kouroumalis , Demetrius Samonakis , George Notas
    The neuropeptide somatostatin has been shown to control the secretion of several hormones and growth factors, but also to inhibit the proliferation of several tumor cells. Hepatocellular carcinoma (HCC) is a leading cause of death all over the world due to very limited treatment modalities. Early reports showed that somatostatin may influence HCC growth, making somatostatin a potential... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:34. | doi:10.20517/2394-5079.2018.33
    Published on: 11 Jul 2018  | Viewed:359  | Downloaded:37
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  • The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

    Saranya Chidambaranathan-Reghupaty , Rachel Mendoza , Paul B. Fisher , Devanand Sarkar
    Staphylococcal nuclease and tudor domain containing 1 (SND1) is a protein that regulates a complex array of functions. It controls gene expression through transcriptional activation, mRNA degradation, mRNA stabilization, ubiquitination and alternative splicing. More than two decades of research has accumulated evidence of the role of SND1 as an oncogene in various cancers. It is a promoter of... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:32. | doi:10.20517/2394-5079.2018.34
    Published on: 10 Jul 2018  | Viewed:381  | Downloaded:21
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  • Performance of different biomarkers for the management of hepatocellular carcinoma

    Ángela Rojas , Yolanda Sánchez-Torrijos , Antonio Gil-Gómez , Chang-Hai Liu , Clara Rodríguez-Rivas , María Teresa Ferrer , Manuel Romero-Gómez
    Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the second cause of cancer related death due to latent liver disease, late diagnosis and non-available therapeutic treatment. Liver biopsy is still the gold standard in order to know the molecular biology of the tumor, its behaviour and invasive characteristics. Conventional diagnosis methods for HCC detection include... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:31. | doi:10.20517/2394-5079.2018.60
    Published on: 6 Jul 2018  | Viewed:888  | Downloaded:111
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  • Hypoxic microenvironment and hepatocellular carcinoma treatment

    Ci-Ai Lin , Lin-Lin Chang , Hong Zhu , Qiao-Jun He , Bo Yang
    Hepatocellular carcinoma (HCC) is one of the most rapidly growing and prevalent cancers in the whole world. The characterized hypoxia region inside the HCC tumors has been recently found as the key driver of HCC malignance and treatment failure, leading to a variety of hypoxia-related biological consequences including angiogenesis, metastasis, metabolism deregulation and drug resistance, which... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:26. | doi:10.20517/2394-5079.2018.27
    Published on: 29 Jun 2018  | Viewed:431  | Downloaded:32
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  • Pathway analysis provides insight into the genetic susceptibility to hepatocellular carcinoma and insight into immuno-therapy treatment response

    Yih-Kuang Lu , Jacob Morris Brill , Ardesher Aghili , Kenneth Howard Buetow
    Clear evidence exists for genetic susceptibility to hepatocellular carcinoma (HCC). Genome-wide association studies have identified multiple candidate susceptibility loci. These loci suggest that genetic variation in the immune system may underpin HCC susceptibility. Genes for the antigen processing and presentation pathway have been observed to be significantly enriched across studies and the... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:21. | doi:10.20517/2394-5079.2018.44
    Published on: 22 Jun 2018  | Viewed:696  | Downloaded:40
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  • Mitoepigenetics and hepatocellular carcinoma

    María Guadalupe Lozano-Rosas , Enrique Chávez , Alejandro Rusbel Aparicio-Cadena , Gabriela Velasco-Loyden , Victoria Chagoya de Sánchez
    Mitochondria are the center of energy production in eukaryotic cells and are crucial for several cellular processes. Dysfunctional mitochondria have been associated with cancer progression. Mitochondria contain their own circular DNA (mtDNA), which codes for 13 proteins, 2rRNA, 22tRNA and non-coding RNAs. Recent evidence showed the presence of 5-methylcytosine and 5-hydroximethylcytosine in... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:19. | doi:10.20517/2394-5079.2018.48
    Published on: 19 Jun 2018  | Viewed:692  | Downloaded:56
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  • T cell immunotherapy in hepatitis B virus related hepatocellular carcinoma

    Morteza Hafezi , Antonio Bertoletti , Anthony T. Tan
    Chronic hepatitis B Virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). While multiple treatment modalities are available, liver transplantation remains the sole curative treatment for advanced stages of HCC, and hence new treatment approaches are required to fulfill this unmet need of curative HCC therapy. Our first-in-man proof-of-concept adoptive T-cell... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:16. | doi:10.20517/2394-5079.2018.55
    Published on: 30 May 2018  | Viewed:1141  | Downloaded:73
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  • New strategy to distinguish clonal origin of RHCC/MHCC between intrahepatic metastasis and multicentric occurrence

    Han Wang , Wen-Ming Cong
    Hepatocellular carcinoma (HCC) is a kind of malignancy with high potential of metastasis and multicentric occurrence. The treatment of recurrent hepatocellular carcinoma (RHCC) and multinodular hepatocellular carcinoma (MHCC) is always a nodus because of the diverse clonal origin of RHCC/MHCC. Theoretically, the RHCC/MHCC can originate from intrahepatic metastasis (IM type) or multicentric... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:14. | doi:10.20517/2394-5079.2018.16
    Published on: 28 May 2018  | Viewed:943  | Downloaded:72
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  • Beta2-glycoprotein I cooperate with hepatitis B surface antigen promotes hepatocellular carcinogenesis via the nuclear factor kappa B signal pathway were enhanced by the lipopolysaccharide

    Xue-Li Ding , Xue Jing , Nai-Jun Han , Zi-Bin Tian , Pu-Jun Gao , Lin Yang , Ya-Nan Yu
    Aim: We aimed to elucidate whether beta2-glycoprotein I (β2GPI) cooperation with hepatitis B surface antigen (HBsAg) promoted hepatocellular carcinogenesis enhanced by the lipopolysaccharide (LPS) via activation of nuclear factor kappa B (NF-κB) and expression of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and alpha fetal protein (AFP) in liver cancer cells. Methods: Liver cancer... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:12. | doi:10.20517/2394-5079.2018.07
    Published on: 28 Apr 2018  | Viewed:618  | Downloaded:45
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  • Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

    Nisha Bhatia , Baljinder Singh , Ashwani Koul
    Aim: The present study was aimed to determine the modulatory role of lycopene enriched tomato extract (LycT) during initiation of N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma (HCC). Methods: Female Balb/c mice were divided into 4 groups: control, NDEA (200 mg NDEA/kg b.wt, cumulative dose), LycT (5 mg/kg b.wt, thrice a week) and LycT + NDEA. LycT administration was commenced 2... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:9. | doi:10.20517/2394-5079.2018.04
    Published on: 27 Mar 2018  | Viewed:1281  | Downloaded:48
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Hepatoma Research ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)
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