Articles
  • Review|Open Access

    Novel predictive and prognostic strategies of hepatitis B virus related hepatocellular carcinoma

    Wen-Bin Liu , Fan Yang , Ding-Yi Shao , Guang-Wen Cao
    Hepatocellular carcinoma (HCC) is a common malignancy and an important cause of cancer death worldwide. Chronic hepatitis B virus (HBV) infection is the major cause of HCC. Recent studies of HBV-induced carcinogenesis not only discovered many new biomarkers but also developed a novel theory:... Read more
    Hepatoma Res 2016;2:331-40. | doi:10.20517/2394-5079.2016.38
    Published on: 23 Dec 2016  | Viewed:1809  | Downloaded:117
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  • Original Article|Open Access

    Effect of obesity on perioperative outcomes after laparoscopic hepatectomy

    Seeyuen J. Lee , Adam Hauch , Erica Kane , Christoper DuCoin , Michael Darden , Geoffrey Parker , Emad Kandil , Joseph F. Buell
    Aim: Laparoscopic hepatectomy is increasing in utilization, however the procedure has not been adequately examined in the obese patient. This study aims to analyze the effect of obesity on perioperative outcomes after laparoscopic hepatectomy. Methods: Retrospective analysis of 396 laparoscopic... Read more
    Hepatoma Res 2016;2:323-7. | doi:10.20517/2394-5079.2016.34
    Published on: 13 Dec 2016  | Viewed:971  | Downloaded:61
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  • Commentary|Open Access

    Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota”

    Anna Egresi , Krisztina Hagymási , Gabriella Lengyel
    Hepatoma Res 2016;2:328-30. | doi:10.20517/2394-5079.2016.31
    Published on: 13 Dec 2016  | Viewed:823  | Downloaded:80
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  • Original Article|Open Access

    Role of contrast-enhanced ultrasound in the evaluation of vascularization of hepatocellular carcinoma

    Francesco Loria , Giuseppe Loria , Salvatore Basile , Giuseppe Crea , Luciano Frosina , Francesca Frosina
    Aim: Early individualization of hepatocellular carcinoma is crucial to obtain good therapeutic results, thanks to several options such as percutaneous therapies, surgical resections and transplant. Aim of this study is to evaluate the vascularization of hepatocarcinoma using contrast enhanced... Read more
    Hepatoma Res 2016;2:316-22. | doi:10.20517/2394-5079.2016.27
    Published on: 22 Nov 2016  | Viewed:1185  | Downloaded:89
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  • Original Article|Open Access

    Evaluating normalization approaches for the better identification of aberrant microRNAs associated with hepatocellular carcinoma

    Jing Shen , Qiao Wang , Irina Gurvich , Helen Remotti , Regina M. Santella
    Aim: Dysregulated microRNAs (miRNAs) have been identified in hepatocellular carcinoma (HCC), but only a small proportion have been confirmed. An appropriate normalizer is crucial to determining the accuracy and reliability of data from miRNA studies. Methods: Different normalization strategies... Read more
    Hepatoma Res 2016;2:305-15. | doi:10.20517/2394-5079.2016.28
    Published on: 18 Nov 2016  | Viewed:1649  | Downloaded:85
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  • Case Report|Open Access

    Aggressive primary hepatic histiocytic sarcoma: case report and literature review

    Guang Yang , Jeremy Deisch , Haixia Qin , Craig Zuppan , Anwar S. Raza
    Histiocytic sarcoma is an uncommon non-Langerhans histiocyte disorder of mature tissue histiocytes. The authors presented an example of this rare tumor in a 14-year-old girl who presented with left upper quadrant pain, loss of appetite, and weight loss. A large 18 cm × 10 cm heterogeneous solid... Read more
    Hepatoma Res 2016;2:300-4. | doi:10.20517/2394-5079.2016.10
    Published on: 7 Nov 2016  | Viewed:1512  | Downloaded:62
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  • Case Report|Open Access

    An extra-adrenal pheochromocytoma mimicking a primary liver cancer

    Kenneth Siu Ho Chok , Florence Loong , Chung Mau Lo
    Despite doctors’ every effort to be vigilant when diagnosing, sometimes a preoperative diagnosis is disproved by postoperative pathological examination. A patient was diagnosed with hepatocellular carcinoma and received surgery as treatment. On operation, a solitary retroperitoneal mass rather... Read more
    Hepatoma Res 2016;2:297-9. | doi:10.20517/2394-5079.2016.04
    Published on: 7 Nov 2016  | Viewed:1593  | Downloaded:65
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  • Case Report|Open Access

    Hepatocarcinoma with metastasis to the anterior mediastinum

    Rogério Camargo Pinheiro Alves , Lorena Sagrilo Auer , Lisa Rodrigues da Cunha Saud , Raquel Coris Arrelaro , Aline Carboni Casado , Bruno Gustavo Ferreira , Denis Szjenfeld , Paula Bechara Poletti
    Liver malignancies are the sixth leading cause of cancer worldwide, whereas hepatocellular carcinoma (HCC) is the most frequent histological type of liver cancer. Extrahepatic metastasis, which rarely involves the mediastinum, is associated with poor prognosis. An 80-year-old male presenting with... Read more
    Hepatoma Res 2016;2:293-6. | doi:10.20517/2394-5079.2016.01
    Published on: 21 Oct 2016  | Viewed:1353  | Downloaded:107
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  • Original Article|Open Access

    Is transarterial embolization a valuable treatment option for spontaneous rupture of hepatocellular carcinoma: experience from a tertiary care hospital of South-Asia

    Amna Subhan Butt , Saeed Hamid , Nazish Butt , Fatima Sharif , Tanveer Ul Haq , Wasim Jafri
    Aim: Transarterial embolization (TAE) has been found beneficial in treatment of ruptured Hepatocellular carcinoma (HCC) in earlier studies. So far no data is available from Pakistan. The aim of this study was to evaluate clinicopathological characteristics, outcomes of patients presented with... Read more
    Hepatoma Res 2016;2:279-86. | doi:10.20517/2394-5079.2016.08
    Published on: 21 Oct 2016  | Viewed:2119  | Downloaded:120
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  • Case Report|Open Access

    Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis with an unusual presentation of abdominal compartment syndrome

    Li Lei , Camilla J. Cobb , Jeffrey Cao , Anwar S. Raza
    Hemophagocytic lymphohistiocytosis (HLH) is a cytokine storm syndrome caused by an overactive but ineffective immune reaction. Without prompt diagnosis and treatment, HLH is life-threatening. However, presenting symptoms are often nonspecific, with fatigue and fever being the most common. A high... Read more
    Hepatoma Res 2016;2:287-92. | doi:10.20517/2394-5079.2016.18
    Published on: 21 Oct 2016  | Viewed:1491  | Downloaded:66
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Liver resection for hepatocellular carcinoma within a fast-track management: a propensity-score matched analysis between open and laparoscopic approach

    Francesca Ratti , Federica Cipriani , Raffaella Reineke , Marco Catena , Michele Paganelli , Luigi Beretta , Luca Aldrighetti
    Aim: The study was designed to assess the implications of enhanced recovery after surgery (ERAS) approach in patients submitted to open liver resection for hepatocellular carcinoma (HCC) comparing their short term outcome with patients treated by laparoscopic approach, in a case-matched design.... Read more
    Hepatoma Res 2016;2:271-8. | doi:10.20517/2394-5079.2016.20
    Published on: 30 Sep 2016  | Viewed:1025  | Downloaded:67
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic resection of hepatocellular carcinoma in patients with and without cirrhosis: the Brisbane experience

    Daniel J. Kilburn , Universe Leung , David J. Cavallucci , Cassandra Jeavons , Mehan Siriwardhane , Richard Bryant , Thomas R. O’Rourke , Shinn Yeung , Nicholas A. O’Rourke
    Aim: Laparoscopic liver resection for hepatocellular carcinoma (HCC) is increasingly common around the world. There may be significant advantages over open resections. However, due to technical difficulties, they are performed in few centers with expertise in liver and advanced laparoscopic... Read more
    Hepatoma Res 2016;2:264-70. | doi:10.20517/2394-5079.2016.29
    Published on: 30 Sep 2016  | Viewed:1330  | Downloaded:106
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic liver resection for hepatocellular carcinoma in patients with cirrhosis

    Jai Young Cho , Ho-Seong Han
    Hepatocellular carcinoma (HCC) is a common malignant tumor and many cases occur in patients with liver cirrhosis. Although liver transplantation is the most effective treatment option, hepatectomy is still the first curative treatment option because liver transplantation is limited by the donors... Read more
    Hepatoma Res 2016;2:259-63. | doi:10.20517/2394-5079.2016.13
    Published on: 30 Sep 2016  | Viewed:1157  | Downloaded:102
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Case report of the fourth laparoscopic liver resection and review of repeat laparoscopic resection for recurrent hepatocellular carcinoma in cirrhotic liver

    Zenichi Morise , Masashi Isetani , Norihiko Kawabe Norihiko Kawabe , Hirokazu Tomishige , Hidetoshi Nagata , Satoshi Arakawa , Masahiro Ikeda , Kenshiro Kamio
    A 73-year-old woman with liver cirrhosis caused by hepatitis C virus (HCV) underwent treatment of three hepatocellular carcinomas (HCCs) in liver segment 4, following three previous laparoscopic liver resections (LLRs) over 73 months. Contrast-enhanced computed tomography showed three 0.5-1.2 cm... Read more
    Hepatoma Res 2016;2:253-8. | doi:10.20517/2394-5079.2016.09
    Published on: 19 Sep 2016  | Viewed:1980  | Downloaded:73
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic liver resection in the cirrhotic patient

    Ben Robichaux , Jesse Sulzer , Joseph F. Buell
    Aim: The adoption of laparoscopic liver resection has been expansive in the last 2 decades with the exception of cirrhotic patients. The current study examines the outcomes of our cirrhotic resections to determine the potential limitations of this technique. Methods: Retrospective analysis of 114... Read more
    Hepatoma Res 2016;2:248-52. | doi:10.20517/2394-5079.2016.23
    Published on: 19 Sep 2016  | Viewed:1167  | Downloaded:59
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Indications and technique for laparoscopic liver resection in patients with hepatocellular carcinoma and liver cirrhosis

    Yuichiro Otsuka , Masaru Tsichiya , Toshio Katagiri , Yoshihisa Kubota , Jun Ishii , Tetsuya Maeda , Hironori Kaneko
    Liver resection is the preferred initial treatment option for solitary or limited multifocal hepatocellular carcinoma (HCC). However, because of the characteristics of HCC, including its high recurrence rate and the frequent presence of chronic hepatitis and cirrhosis, both curability and... Read more
    Hepatoma Res 2016;2:241-7. | doi:10.20517/2394-5079.2016.11
    Published on: 19 Sep 2016  | Viewed:1938  | Downloaded:121
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Introduction of the special issue: “Advances in Minimally Invasive Cirrhotic Surgery”

    Giulio Belli
    Hepatoma Res 2016;2:239-40. | doi:10.20517/2394-5079.2016.16
    Published on: 19 Sep 2016  | Viewed:766  | Downloaded:53
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  • Original Article|Open Access

    Detecting hepatic nodules and identifying feeding arteries of hepatocellular carcinoma: efficacy of cone-beam computed tomography in transcatheter arterial chemoembolization

    Yasuhiro Ushijima , Tsuyoshi Tajima , Akihiro Nishie , Yoshiki Asayama , Kousei Ishigami , Masakazu Hirakawa , Daisuke Kakihara , Daisuke Okamoto , Hiroshi Honda
    Aim: To evaluate the effectiveness of using cone-beam computed tomography (CBCT) in transcatheter arterial chemoembolization (TACE) to detect hapatocellular carcinoma (HCC) nodules and their feeding arteries. Methods: Twenty-four patients with HCCs who underwent TACE using CBCT in addition to... Read more
    Hepatoma Res 2016;2:231-6. | doi:10.20517/2394-5079.2016.32
    Published on: 25 Aug 2016  | Viewed:1564  | Downloaded:84
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  • Commentary|Open Access

    Comment on “Preliminary outcome of microwave ablation of hepatocellular carcinoma: breaking the 3-cm barrier?”

    Paola Tombesi , Francesca Di Vece , Francesca Ermili , Sergio Sartori
    Hepatoma Res 2016;2:237-8. | doi:10.20517/2394-5079.2016.30
    Published on: 25 Aug 2016  | Viewed:1550  | Downloaded:70
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  • Review|Open Access

    Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma

    Hanaa Ali Hassan , Nermin E. El-Gharib , Anmar F. Azhari
    Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in... Read more
    Hepatoma Res 2016;2:216-23. | doi:10.20517/2394-5079.2016.12
    Published on: 5 Aug 2016  | Viewed:95484  | Downloaded:143
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  • Review|Open Access

    Diet and nutrition therapy in pre-liver transplant patients

    Neha Bakshi , Kalyani Singh
    Malnutrition is universally prevalent among pre-liver transplantation patients. Malnutrition among cirrhotic patients had been associated to increased morbidity and mortality rates. Also, severely malnourished patients before the transplant surgery have a higher rate of complications and a... Read more
    Hepatoma Res 2016;2:207-15. | doi:10.20517/2394-5079.2016.02
    Published on: 5 Aug 2016  | Viewed:4369  | Downloaded:183
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  • Original Article|Open Access

    Efficacy of sorafenib therapy in patients with advanced hepatocellular carcinoma in Indian population

    Alit Abraham , Charumathi Purushothaman , Dhanya Damien , Jackson James , Prudence Attilade Rodrigues , Gursharan Singh
    Aim: Hepatocellular carcinoma (HCC) is the fourth most common type of cancer and the third leading cause of cancer-related mortality. Sorafenib is an oral multikinase inhibitor that is used for unresectable advanced HCC. It is only approved systemic therapy for advanced HCC. Methods: A... Read more
    Hepatoma Res 2016;2:224-8. | doi:10.20517/2394-5079.2016.03
    Published on: 5 Aug 2016  | Viewed:1719  | Downloaded:116
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  • Letter to Editor|Open Access

    Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes

    Kunio Takegoshi , Eikichi Okada , Qin Su
    Hepatoma Res 2016;2:229-30. | doi:10.20517/2394-5079.2016.26
    Published on: 5 Aug 2016  | Viewed:1077  | Downloaded:91
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  • Review|Open Access

    Percutaneous hepatic perfusion with melphalan for unresectable liver metastasis

    Humair S. Quadri , Eden C. Payabyab , David J. Chen , William Figg , Marybeth S. Hughes
    Percutaneous hepatic perfusion (PHP) is an investigative technique for treating patients with diffuse unresectable metastatic liver disease. The technique has been clinically evaluated and shows great treatment potential for regional therapy to the liver. The advantage of PHP lies in its... Read more
    Hepatoma Res 2016;2:197-202. | doi:10.20517/2394-5079.2016.24
    Published on: 13 Jul 2016  | Viewed:2932  | Downloaded:141
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  • Brief Communication|Open Access

    Hepatic disorder in Zika virus infection

    Viroj Wiwanitkit
    Zika virus infection is the present global problem. This arbovirus infection can cause acute illness and affect fetus in utero. However, there can be other additional clinical manifestation including to the hepatic disorder. In this short commentary article, the author briefly discusses on the... Read more
    Hepatoma Res 2016;2:203-4. | doi:10.20517/2394-5079.2016.17
    Published on: 13 Jul 2016  | Viewed:1770  | Downloaded:251
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  • Commentary|Open Access

    Comment on "A series of microRNA in the chromosome 14q32.2 maternally imprinted region related to progression of non-alcoholic fatty liver disease in a mouse model”

    Pietro Di Fazio , Thaddeus Till Wissniowski
    Hepatoma Res 2016;2:205-6. | doi:10.20517/2394-5079.2016.19
    Published on: 13 Jul 2016  | Viewed:811  | Downloaded:59
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  • Review|Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard
    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host... Read more
    Hepatoma Res 2016;2:163-86. | doi:10.20517/2394-5079.2016.05
    Published on: 1 Jul 2016  | Viewed:19453  | Downloaded:765
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  • Case Report|Open Access

    Hemorrhagic cardiac tamponade after percutaneous laser ablation of a liver metastasis in segment II

    Paola Tombesi , Francesca Di Vece , Silvia Rinaldi , Matteo Bertini , Sergio Sartori
    Despite percutaneous laser thermal ablation (LTA) of liver tumors being regarded as a safe technique, major complications can occur. We report the first case of hemorrhagic cardiac tamponade after LTA of a colorectal metastasis in segment II of the liver. Unpredictable heat diffusion causing... Read more
    Hepatoma Res 2016;2:193-6. | doi:10.20517/2394-5079.2015.68
    Published on: 1 Jul 2016  | Viewed:1721  | Downloaded:63
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  • Original Article|Open Access

    Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study

    Hiroshi Yoshida , Hiroshi Makino , Tadashi Yokoyama , Hiroshi Maruyama , Atsushi Hirakata , Junji Ueda , Yasuhiro Mamada , Nobuhiko Taniai , Eiji Uchida
    Aim: The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the... Read more
    Hepatoma Res 2016;2:187-92. | doi:10.20517/2394-5079.2016.06
    Published on: 1 Jul 2016  | Viewed:2458  | Downloaded:142
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  • Original Article|Open Access

    Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

    Jing Shen , Abby B. Siegel , Helen Remotti , Qiao Wang , Regina M. Santella
    Aim: Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate “HCC tumor type specific” and “tumor common” miRNA panels. Methods: The authors integrate and analyze clinical,... Read more
    Hepatoma Res 2016;2:151-62. | doi:10.20517/2394-5079.2015.66
    Published on: 1 Jun 2016  | Viewed:4072  | Downloaded:207
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  • Review|Open Access

    Physiological potential of cytokines and liver damages

    Fathia A. Mannaa , Khaled G. Abdel-Wahhab
    Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between... Read more
    Hepatoma Res 2016;2:131-43. | doi:10.20517/2394-5079.2015.58
    Published on: 1 Jun 2016  | Viewed:8997  | Downloaded:281
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  • Original Article|Open Access

    Hepatoprotective and antioxidant activity of Bombax ceiba flowers against carbon tetrachloride-induced hepatotoxicity in rats

    Manish M. Wanjari , Rachna Gangoria , Yadu Nandan Dey , Sudesh N. Gaidhani , Narendra K. Pandey , Ankush D. Jadhav
    Aim: The flowers of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of flowers of Bombax ceiba (BCAE) on experimentally induced hepatotoxicity in rats to substantiate its... Read more
    Hepatoma Res 2016;2:144-50. | doi:10.20517/2394-5079.2015.55
    Published on: 1 Jun 2016  | Viewed:2759  | Downloaded:401
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  • Review|Open Access

    Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis

    Atul Ranjan , Kaustav Bera , Tomoo Iwakuma
    Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet, the mechanisms underlying HCC progression remain unclear. Unlike other cancers, systematic chemotherapy is not effective for HCC patients, while surgical resection and liver... Read more
    Hepatoma Res 2016;2:114-21. | doi:10.20517/2394-5079.2015.67
    Published on: 6 May 2016  | Viewed:2089  | Downloaded:114
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  • Review|Open Access

    Human telomerase disease mutants and its relation with hepatocarcinoma

    Yin-Nan Chen , Yan-Min Zhang
    Telomerase is a special reverse transcriptase, which adds telomeric DNA repeats to the ends of chromosome to offset loss. A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustain proliferation and growth. Hepatocellular carcinoma (HCC) is one of the most... Read more
    Hepatoma Res 2016;2:109-13. | doi:10.20517/2394-5079.2015.56
    Published on: 6 May 2016  | Viewed:1899  | Downloaded:144
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  • Original Article|Open Access

    Can gender predict virological response to standard antiviral therapy for chronic hepatitis C? A retrospective study

    Paola Belci , Alessandro Collo , Maria Martorana , Andrea Evangelista , Sara Giunti , Roberto Gambino , Maurizio Cassader , Simona Bo , Marilena Durazzo
    Aim: The liver is a sexually dimorphic organ presenting gender differences in its metabolism, functions, enzyme activity, membrane lipid composition and immune response. This paper aimed to assess whether gender may predict virological response to standard antiviral therapy in subjects with... Read more
    Hepatoma Res 2016;2:122-30. | doi:10.20517/2394-5079.2015.53
    Published on: 6 May 2016  | Viewed:1412  | Downloaded:64
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  • Original Article|Open Access

    Surgical resection or radiofrequency ablation in the management of hepatocellular carcinoma: single center experience

    Wael Mansy , Morsi Mohammed , Sameh Saber
    Aim: The aim of this study is to prove or disprove the superiority of surgical resections over radiofrequency ablation (RFA) with respect to efficacy and safety. Methods: The study was conducted in Zagazig University Hospitals, which included 40 patients with hepatocellular carcinoma (HCC) during... Read more
    Hepatoma Res 2016;2:92-7. | doi:10.4103/2394-5079.169642
    Published on: 1 Apr 2016  | Viewed:3293  | Downloaded:114
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  • Case Report|Open Access

    Spontaneous rupture of hepatocellular carcinoma

    Amer Hawatmeh , Khalid Jumean , Ahmed Abu Arqoub , Hamid Shaaban
    This is a very interesting case of a 64-year-old female with a history of chronic hepatitis C infection, with abdominal pain and was found to have ruptured hepatocellular carcinoma (HCC). She was managed with the two-stage therapeutic approach first using transarterial embolization to provide... Read more
    Hepatoma Res 2016;2:103-6. | doi:10.4103/2394-5079.171207
    Published on: 1 Apr 2016  | Viewed:2055  | Downloaded:153
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  • Original Article|Open Access

    Arterial blood supply of hepatocellular carcinoma is associated with efficacy of sorafenib therapy

    Xiang-Hua Zhang , Qian Zhu , Jing Li , Liang Huang , Jian-Jun Yan , Feng Xu , Jun Li , Yi-Qun Yan
    Aim: There are some previous reports concerning the relationship between prognosis of patients treated with sorafenib and parameters of computed tomography (CT) and magnetic resonance imaging (MRI). This study presents monocentric experience with sorafenib in the treatment of hepatocellular... Read more
    Hepatoma Res 2016;2:87-91. | doi:10.4103/2394-5079.170542
    Published on: 1 Apr 2016  | Viewed:1088  | Downloaded:113
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  • Case Report|Open Access

    Nutrition profile of a liver transplant recipient

    Neha Bakshi , Kalyani Singh
    Malnutrition is almost universally present in patients undergoing liver transplantation. In this report, a male adult patient was followed from his pre-liver transplant phase until chronic post-transplant phase (3 months after the transplant). Improvement in nutrition status, quality of life, and... Read more
    Hepatoma Res 2016;2:98-102. | doi:10.4103/2394-5079.168958
    Published on: 1 Apr 2016  | Viewed:2148  | Downloaded:72
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  • Letter to Editor|Open Access

    Microwave coagulation therapy: the future is quite rosy

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Hepatoma Res 2016;2:107-8. | doi:10.4103/2394-5079.170543
    Published on: 1 Apr 2016  | Viewed:1045  | Downloaded:41
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

    Mosaad A. Abdel-Wahhab , Olivier Joubert , Aziza A. El-Nekeety , Hafiza A. Sharaf , Ferial M. Abu-Salem , Bertrand H. Rihn
    Aim: This study aimed to determine the composition of ethanol extract of jojoba seeds, and to evaluate its hepatoprotective effects in rats fed fumonisin B1 (FB1)-contaminated diet. Methods: Jojoba seeds were extracted in 95% ethanol, and the chemical composition was determined. Male rats were... Read more
    Hepatoma Res 2016;2:78-86. | doi:10.4103/2394-5079.168078
    Published on: 9 Mar 2016  | Viewed:2780  | Downloaded:201
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Coffee, Traditional Chinese Medicine and cannabinoids as potential tools for prevention and treatment of hepatocellular carcinoma

    Stefano Gitto , Ranka Vukotic , Pietro Andreone
    In the last decade, the incidence of hepatocellular carcinoma (HCC) is growing in both Europe and United States. Conventional therapies such as liver resection, transplantation, ablation, chemoembolization and sorafenib are not enough to avoid a significant mortality. Many studies suggested the... Read more
    Hepatoma Res 2016;2:71-7. | doi:10.20517/2394-5079.2015.63
    Published on: 9 Mar 2016  | Viewed:2023  | Downloaded:117
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse... Read more
    Hepatoma Res 2016;2:62-70. | doi:10.20517/2394-5079.2015.59
    Published on: 9 Mar 2016  | Viewed:7265  | Downloaded:309
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise... Read more
    Hepatoma Res 2016;2:53-61. | doi:10.20517/2394-5079.2015.64
    Published on: 9 Mar 2016  | Viewed:3656  | Downloaded:168
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  • Original Article|Open Access

    Predictive factors for the success of “one-off” ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

    Jian-Yun Long , Jing Li , Jie Cao , Liang Huang , Xiang-Hua Zhang , Jin-Kai Liu , Yi-Qun Yan
    Aim: To investigate the technique' s effectiveness and evaluate the risk factors affecting the success of "one-off" percutaneous ultrasound-guided radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC). Methods: A total of 462 consecutive patients who received RFA from February... Read more
    Hepatoma Res 2016;2:47-52. | doi:10.4103/2394-5079.172726
    Published on: 29 Feb 2016  | Viewed:1140  | Downloaded:62
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  • Original Article|Open Access

    Fascin-1 depletion from hepatocellular carcinoma cells inhibits migfilin and vasodilator-stimulated phosphoprotein expression and enhances adhesiona

    Vasiliki Gkretsi , Dimitrios P. Bogdanos
    Aim: Extracellular matrix (ECM)-adhesions and their interaction with actin cytoskeleton are fundamental for hepatocellular carcinoma (HCC). Fascin-1, an actin-bundling protein, is correlated with poor HCC prognosis, and is known regarding the molecular mechanism of its action. In this study, the... Read more
    Hepatoma Res 2016;2:42-6. | doi:10.4103/2394-5079.168071
    Published on: 29 Feb 2016  | Viewed:1165  | Downloaded:59
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  • Original Article|Open Access

    Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

    Adam Hauch , Carl Winkler , Eric Katz , Peter W. Lundberg , Mary Killackey , Anil S. Paramesh , Luis A. Balart , Nathan J. Shores , Martin Moehlen , Ward Miller , Douglas P. Slakey , Joseph F. Buell , Bob H. Saggi
    Aim: Portal vein thrombosis (PVT) in the liver transplant recipient poses many challenges. Unfortunately, the risk factors and effects on outcomes of PVT are not well-defined. Methods: This study analyzed the experience with PVT in liver transplant program from 2007 to 2013. This included the... Read more
    Hepatoma Res 2016;2:36-41. | doi:10.4103/2394-5079.168070
    Published on: 29 Feb 2016  | Viewed:2317  | Downloaded:68
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  • Review|Open Access

    Recent updates of genetic and genomic alterations in hepatocellular carcinoma

    Zhang Zhao , Jian Huang
    Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide. However, the molecular mechanisms underlining the development and progression of HCC remain unclear. Genetic and genomic alterations are common events in various types of cancers including HCC. With the... Read more
    Hepatoma Res 2016;2:31-5. | doi:10.4103/2394-5079.168446
    Published on: 29 Feb 2016  | Viewed:1185  | Downloaded:119
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  • Review|Open Access

    Role of antiviral therapy in patients with chronic hepatitis B or C virus in preventing the development of hepatocellular carcinoma

    Laura Scribano , Veronica Vanin , Giorgia Gottardo , Diana Sacchi , Francesco Paolo Russo
    Patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are at significant risk for hepatocellular carcinoma (HCC). The most important risk factor associated with HCC is liver cirrhosis, which is again predominantly caused by chronic HBV or HCV infection. The most... Read more
    Hepatoma Res 2016;2:10-7. | doi:10.4103/2394-5079.168961
    Published on: 15 Jan 2016  | Viewed:1817  | Downloaded:170
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  • Review|Open Access

    Interventional radiology therapies for liver cancer

    Romaric Loffroy , Louis Estivalet , Sylvain Favelier , Pierre Pottecher , Pierre-Yves Genson , Jean-Pierre Cercueil , Denis Krausé
    Hepatocellular carcinoma (HCC) is the fifth most frequently found primary malignant tumor in the world. Hepatic surgery and liver transplantation are considered optimal for the curative treatment of HCC. However, only 15-20% of HCCs may be surgically treated. Most of the surgically-non-eligible... Read more
    Hepatoma Res 2016;2:1-9. | doi:10.4103/2394-5079.167439
    Published on: 15 Jan 2016  | Viewed:1326  | Downloaded:138
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  • Original Article|Open Access

    Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

    Mohamed Ahmed Samy Kohla , Om Kolsoum Al-Haddad , Ali Nada , Mohamed Al-Warraky , Manar Obada , Mohamed Amer , Sameera Ezzat , Ashraf Abou Gabal
    Aim: Epidermal growth factor (EGF) is a mitogen for hepatocyte grown in vitro, and its expression is up-regulated during liver regeneration. EGF also plays an important role in tumor initiation and progression. The goal of this study is to assess whether EGF is associated with advanced... Read more
    Hepatoma Res 2016;2:18-25. | doi:10.4103/2394-5079.168959
    Published on: 15 Jan 2016  | Viewed:2689  | Downloaded:102
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  • Case Report|Open Access

    Hepatocellular carcinoma and type 2 diabetes mellitus: two cases highlighting changes in tumor glycogen content

    Kunio Takegoshi , Eikichi Okada , Kazuhiro Nomoto , Kouji Nobata , Takuro Sawasaki , Mitsuhiro Terada , Hirofumi Terakawa , Takashi Kobayashi , Kazuhisa Yabushita , Tatsuho Sugimoto , Shintaro Terahata
    This article reports two patients with hepatocellular carcinoma (HCC) and type 2 diabetes mellitus (T2DM), who showed marked changes in hepatocellular glycogen content. Periodic acid-Schiff (PAS)-positive and diastase-PAS-negative (glycogen-storing) hepatocytes were detected in both background... Read more
    Hepatoma Res 2016;2:26-30. | doi:10.4103/2394-5079.168725
    Published on: 15 Jan 2016  | Viewed:1558  | Downloaded:81
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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