Articles
  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a... Read more
    Hepatoma Res 2015;1:147-54. | doi:10.4103/2394-5079.167376
    Published on: 15 Oct 2015  | Viewed:6486  | Downloaded:291
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with... Read more
    Hepatoma Res 2015;1:136-46. | doi:10.4103/2394-5079.167377
    Published on: 15 Oct 2015  | Viewed:6308  | Downloaded:164
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were... Read more
    Hepatoma Res 2015;1:125-35. | doi:10.4103/2394-5079.167375
    Published on: 15 Oct 2015  | Viewed:8196  | Downloaded:290
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor... Read more
    Hepatoma Res 2015;1:119-24. | doi:10.4103/2394-5079.167379
    Published on: 15 Oct 2015  | Viewed:5556  | Downloaded:304
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases... Read more
    Hepatoma Res 2015;1:111-8. | doi:10.4103/2394-5079.167378
    Published on: 15 Oct 2015  | Viewed:6242  | Downloaded:420
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  • Review|Open Access

    “PERISH” flowchart for selection of the patients with resectable hepatocellular carcinoma

    Cuneyt Kayaalp , H. Kerem Tolan , Mehmet Caglikulekci
    A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms/staging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always diffi culties in remembering and/or recalling the contents of... Read more
    Hepatoma Res 2015;1:165-70. | doi:10.4103/2394-5079.161329
    Published on: 15 Oct 2015  | Viewed:19502  | Downloaded:261
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Hepatoma Res 2015;1:109-10. | doi:10.4103/2394-5079.161332
    Published on: 15 Oct 2015  | Viewed:41061  | Downloaded:201
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  • Review|Open Access

    Microwave coagulation therapy of hepatocellular carcinoma

    Yong-Song Guan
    Microwave coagulation therapy (MCT) is a relatively new method of tumor ablation compared to other minimally invasive local therapies for hepatocellular carcinoma (HCC). It is a thermal ablation modality based on the application of heat, potentially leading to larger ablation zones. In recent... Read more
    Hepatoma Res 2015;1:159-64. | doi:10.4103/2394-5079.164648
    Published on: 15 Oct 2015  | Viewed:6912  | Downloaded:228
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Hepatoma Res 2015;1:107-8. | doi:10.4103/2394-5079.161626
    Published on: 15 Oct 2015  | Viewed:4720  | Downloaded:116
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  • Review|Open Access

    Expectations for partial splenic arterial embolization simultaneous transcatheter arterial chemoembolization for hepatocellular carcinoma

    Toru Ishikawa
    Hepatocellular carcinoma (HCC) is frequently complicated by cirrhosis, and it is not unusual for treatment options to be limited as a result of pancytopenia due to hypersplenism. Partial splenic embolization (PSE) has been performed for thrombocytopenia resulting from hypersplenism. However, the... Read more
    Hepatoma Res 2015;1:155-8. | doi:10.4103/2394-5079.161284
    Published on: 15 Oct 2015  | Viewed:7087  | Downloaded:143
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  • Original Article|Open Access

    Sorafenib suppresses hepatitis B virus gene expression via inhibiting JNK pathway

    Hyun Kook Cho , Ju Ran Kim , So Young Kim , Yi Yi Kyaw , Aye Aye Win , Jae Hun Cheong
    Aim: Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases. Sorafenib is a multikinase inhibitor and an approved anti-liver cancer drug. Here we demonstrated the antiviral effect of sorafenib on HBV gene expression. Methods: To investigate the effect of sorafenib on HBV... Read more
    Hepatoma Res 2015;1:97-103. | doi:10.4103/2394-5079.158391
    Published on: 15 Jul 2015  | Viewed:8313  | Downloaded:106
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  • Original Article|Open Access

    Long-term immune-modulatory side effects of radiofrequency ablation in patients with liver metastases and hepatocellular carcinoma

    Thaddeus Till Wissniowski , Thomas Gress , Pietro Di Fazio
    Aim: Used as a palliative therapy for unresectable liver cancer, radiofrequency ablation (RFA) is associated with the induction of immunological responses. Here, we show strong evidence of tumor-specific peripheral blood mononuclear cells (PBMCs) 12 months after RFA. Methods: Three patients with... Read more
    Hepatoma Res 2015;1:92-6. | doi:10.4103/2394-5079.158024
    Published on: 15 Jul 2015  | Viewed:6896  | Downloaded:92
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  • Editorial|Open Access

    Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique?

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Hepatoma Res 2015;1:52-7. | doi:10.4103/2394-5079.155697
    Published on: 15 Jul 2015  | Viewed:7233  | Downloaded:274
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  • Original Article|Open Access

    Laparoscopic radiofrequency ablation for hepatocellular carcinoma

    Anna Sánchez-López , Anna Pallisera-Lloveras , Ramon Saiz-Mendiguren , Manuel Ferrer-Marsal , José Carlos Vicens-Arbona , José Andrés Cifuentes-Ródenas , Jose Manuel Ramia
    Aim: The optimal treatment for hepatocellular carcinoma (HCC) is either surgical resection or liver transplantation, but only one-third of the patients are suitable candidates for surgery. Laparoscopic radiofrequency ablation (RFA) in selected patients is a safe, feasible technique, which has... Read more
    Hepatoma Res 2015;1:86-91. | doi:10.4103/2394-5079.157692
    Published on: 15 Jul 2015  | Viewed:8277  | Downloaded:107
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  • Editorial|Open Access

    Preneoplastic foci in mice fed diethyl 1, 4-dihydro, 1, 4, 6-trimethyl 3, 5-pyridine decarboxylate are resistant to protoporphyrin accumulation

    Samuel W. French , M. Waheed Roomi
    Hepatoma Res 2015;1:50-1. | doi:10.4103/2394-5079.155984
    Published on: 15 Jul 2015  | Viewed:5346  | Downloaded:92
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  • Review|Open Access

    Hepatoma and trematode infestation: a short review

    Viroj Wiwanitkit
    Hepatoma is a common cancer that can be seen around the world and clinical correlation between infection and hepatoma is evident. Hepatitis virus infection is proved for its relationship with hepatoma. However, the knowledge of other infections is still limited. In this short review, the... Read more
    Hepatoma Res 2015;1:63-6. | doi:10.4103/2394-5079.158390
    Published on: 15 Jul 2015  | Viewed:6456  | Downloaded:76
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  • Original Article|Open Access

    Aqueous extract of Corchorus olitorius decreases cytotoxicity of aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Afl atoxin B1 (AFB1) and fumonisin B1 (FB1) are important food-borne mycotoxins. Co-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to... Read more
    Hepatoma Res 2015;1:75-85. | doi:10.4103/2394-5079.155692
    Published on: 15 Jul 2015  | Viewed:8280  | Downloaded:166
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  • Editorial|Open Access

    The evolving role of laparoscopic ablation

    Joseph F. Buell
    Hepatoma Res 2015;1:49. | doi:10.4103/2394-5079.159519
    Published on: 15 Jul 2015  | Viewed:6166  | Downloaded:95
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  • Review|Open Access

    Hepatocellular carcinoma in elderly patients: a concise review on systemic therapy with sorafenib

    Lombardi Giuseppe , Vitale Alessandro , Sara Lonardi , Bellu Luisa , Pambuku Ardi , Marsico Valentina , Crivellari Gino , Aliberti Camillo , Cillo Umberto , Zagonel Vittorina
    The treatment of hepatocellular carcinoma (HCC) in elderly patients is unclear. In particular, the efficacy and safety of sorafenib as a systemic treatment in these patients is still under debate. We performed a concise review of sorafenib therapy in this population. However, it is important to... Read more
    Hepatoma Res 2015;1:58-62. | doi:10.4103/2394-5079.157695
    Published on: 15 Jul 2015  | Viewed:7445  | Downloaded:156
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  • Original Article|Open Access

    Anti-proliferative and apoptotic effificacy of diallyl disulfide on Ehrlich ascites carcinoma

    Osama M. Ahmed , Rasha R. Ahmed
    Aim: This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfide (DADS) against Ehrlich ascites carcinoma (EAC) and to suggest its probable mechanism of action. Methods: EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock... Read more
    Hepatoma Res 2015;1:67-74. | doi:10.4103/2394-5079.157602
    Published on: 15 Jul 2015  | Viewed:9442  | Downloaded:198
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  • Case Report|Open Access

    Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib: a case report and literature review

    Kenneth Siu Ho Chok , Ian Yu Hong Wong , See Ching Chan , Ronnie Tung Ping Poon , Chung Mau Lo
    Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) invasion and metastatic lymph node metastases has a poor prognosis, and surgical resection is seldom indicated. We report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor... Read more
    Hepatoma Res 2015;1:104-6. | doi:10.4103/2394-5079.155694
    Published on: 15 Jul 2015  | Viewed:5256  | Downloaded:132
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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