Articles
  • Topic: Natural Products and Hepatocellular Carcinoma

    Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w)...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with different concentrations of AFB1 and/or FB1 for 24 and 48 h with or without aqueous extract of A. hybridus. Results: AFB1 decreased the viability of cells after 24 and 48 h of exposure. EC50 values for AFB1 were 10.5 and 1.8 μmol/L for the two periods, respectively. When the 48 h exposure to...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were divided into 6 groups (8 rats each) and treated orally for 28 consecutive days as follows. Group 1: rats were given normal saline and used as controls; group 2: rats treated with CFME (200 mg/kg); group 3: rats treated with FSME (200 mg/kg); group 4: rats treated with AZA (25 mg/kg); and groups 5 and 6:...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor response. Several studies aimed at discovering more molecules for the management of HCC. Those studies aimed at recognizing and targeting several signaling and molecular pathways that lead to cellular proliferation and tumor formation. In this review, we discussed the role of several agents found in natural...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in humans. Several researches have been reported numerous natural and phytochemical compounds that may counteract or prevent the hepatic injury and primary liver cancer. The conservative treatment of liver toxicity and HCC may face awkward challenges in chemotherapy such as therapeutic failure or...
    Published on: 15 Oct 2015
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  • Review

    “PERISH” flowchart for selection of the patients with resectable hepatocellular carcinoma

    Cuneyt Kayaalp , H. Kerem Tolan , Mehmet Caglikulekci
    A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms/staging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always diffi culties in remembering and/or recalling the contents of the algorithms/staging systems. Moreover, most algorithms/staging systems do not include data about the extent of hepatectomy, intra-hepatic distribution of tumor(s), and technical feasibility of resection, all of which are vital in the surgeons’ decision-making process. Here, we aimed to present a...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Published on: 15 Oct 2015
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  • Review

    Microwave coagulation therapy of hepatocellular carcinoma

    Yong-Song Guan
    Microwave coagulation therapy (MCT) is a relatively new method of tumor ablation compared to other minimally invasive local therapies for hepatocellular carcinoma (HCC). It is a thermal ablation modality based on the application of heat, potentially leading to larger ablation zones. In recent years, there is a steady increase in the application of this modality to the treatment of HCC because it offers several advantages in the management of tumors larger than 3 cm in diameter. This article reviews the advances in MCT for the treatment of HCC in recent years including its brief history,...
    Published on: 15 Oct 2015
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  • Topic: Natural Products and Hepatocellular Carcinoma

    Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Published on: 15 Oct 2015
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  • Review

    Expectations for partial splenic arterial embolization simultaneous transcatheter arterial chemoembolization for hepatocellular carcinoma

    Toru Ishikawa
    Hepatocellular carcinoma (HCC) is frequently complicated by cirrhosis, and it is not unusual for treatment options to be limited as a result of pancytopenia due to hypersplenism. Partial splenic embolization (PSE) has been performed for thrombocytopenia resulting from hypersplenism. However, the safety and effi cacy of concurrent transcatheter arterial chemoembolization (TACE) with PSE for HCC remain unclear. Thrombocytopenia has been improved, and treatment continued using concurrent PSE. In addition, the hepatic functional reserve could be maintained even after treatment for HCC....
    Published on: 15 Oct 2015
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  • Original Article

    Sorafenib suppresses hepatitis B virus gene expression via inhibiting JNK pathway

    Hyun Kook Cho , Ju Ran Kim , So Young Kim , Yi Yi Kyaw , Aye Aye Win , Jae Hun Cheong
    Aim: Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases. Sorafenib is a multikinase inhibitor and an approved anti-liver cancer drug. Here we demonstrated the antiviral effect of sorafenib on HBV gene expression. Methods: To investigate the effect of sorafenib on HBV gene expression, a luciferase assay was performed with ×1.3 Cp-luciferase HBV construct and reverse transcriptase polymerase chain reaction (PCR), real-time PCR, and Western blotting analyses were performed using HepG2 cells derived from hepatocellular carcinoma and Chang liver cells derived from a...
    Published on: 15 Jul 2015
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  • Original Article

    Long-term immune-modulatory side effects of radiofrequency ablation in patients with liver metastases and hepatocellular carcinoma

    Thaddeus Till Wissniowski , Thomas Gress , Pietro Di Fazio
    Aim: Used as a palliative therapy for unresectable liver cancer, radiofrequency ablation (RFA) is associated with the induction of immunological responses. Here, we show strong evidence of tumor-specific peripheral blood mononuclear cells (PBMCs) 12 months after RFA. Methods: Three patients with colorectal cancer (CRC) metastases to the liver and two patients with primary hepatocellular carcinoma (HCC) were enrolled in this study. PBMC, isolated 12 months after RFA, were stimulated with normal and tumor tissue lysate. Interferon gamma secretion was evaluated by flow cytometry and...
    Published on: 15 Jul 2015
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  • Editorial

    Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique?

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Published on: 15 Jul 2015
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  • Original Article

    Laparoscopic radiofrequency ablation for hepatocellular carcinoma

    Anna Sánchez-López , Anna Pallisera-Lloveras , Ramon Saiz-Mendiguren , Manuel Ferrer-Marsal , José Carlos Vicens-Arbona , José Andrés Cifuentes-Ródenas , Jose Manuel Ramia
    Aim: The optimal treatment for hepatocellular carcinoma (HCC) is either surgical resection or liver transplantation, but only one-third of the patients are suitable candidates for surgery. Laparoscopic radiofrequency ablation (RFA) in selected patients is a safe, feasible technique, which has proved to be superior to the percutaneous approach in patients with severe liver disease or in lesions in which the percutaneous approach is impossible. The aim of this study is to present our experience with laparoscopic RFA and demonstrate its safety as an alternative therapeutic procedure in...
    Published on: 15 Jul 2015
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  • Editorial

    Preneoplastic foci in mice fed diethyl 1, 4-dihydro, 1, 4, 6-trimethyl 3, 5-pyridine decarboxylate are resistant to protoporphyrin accumulation

    Samuel W. French , M. Waheed Roomi
    Published on: 15 Jul 2015
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  • Review

    Hepatoma and trematode infestation: a short review

    Viroj Wiwanitkit
    Hepatoma is a common cancer that can be seen around the world and clinical correlation between infection and hepatoma is evident. Hepatitis virus infection is proved for its relationship with hepatoma. However, the knowledge of other infections is still limited. In this short review, the relationship between hepatoma and some trematode infestation including echinococcosis fascioliasis, opisthorchiasis, clonorchiasis and schistosomiasis are described and discussed. Opisthorchiasis and clonorchiasis are confi rmed for cholangiocarcinoma carcinogenesis but still lack evidence for hepatoma...
    Published on: 15 Jul 2015
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  • Original Article

    Aqueous extract of Corchorus olitorius decreases cytotoxicity of aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Afl atoxin B1 (AFB1) and fumonisin B1 (FB1) are important food-borne mycotoxins. Co-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to these mycotoxins in grain are greatest. The aim of the current study was to evaluate the potential protective effects of an aqueous extract of Cochorus olitorius (C. olitorius, moroheiya) against cytotoxicity of AFB1 and/or FB1 in H4IIE-luc rat hepatoma cells, using assays to measure cell viability...
    Published on: 15 Jul 2015
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  • Editorial

    The evolving role of laparoscopic ablation

    Joseph F. Buell
    Published on: 15 Jul 2015
    [HTML]   [PDF]   Viewed:6063   Downloaded:94
  • Review

    Hepatocellular carcinoma in elderly patients: a concise review on systemic therapy with sorafenib

    Lombardi Giuseppe , Vitale Alessandro , Sara Lonardi , Bellu Luisa , Pambuku Ardi , Marsico Valentina , Crivellari Gino , Aliberti Camillo , Cillo Umberto , Zagonel Vittorina
    The treatment of hepatocellular carcinoma (HCC) in elderly patients is unclear. In particular, the efficacy and safety of sorafenib as a systemic treatment in these patients is still under debate. We performed a concise review of sorafenib therapy in this population. However, it is important to make any decisions on treatment for elderly patients with HCC through a multidisciplinary team that includes experts in the liver disease. Patients with good clinical conditions should be treated with sorafenib.
    Published on: 15 Jul 2015
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  • Original Article

    Anti-proliferative and apoptotic effificacy of diallyl disulfide on Ehrlich ascites carcinoma

    Osama M. Ahmed , Rasha R. Ahmed
    Aim: This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfide (DADS) against Ehrlich ascites carcinoma (EAC) and to suggest its probable mechanism of action. Methods: EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock mice. EAC-bearing mice were orally treated with 100 mg/kg body weight for 2 weeks beginning from the 1st day of EAC intraperitoneal transplantation. Cytotoxicity effects of DADS against EAC-cells in vitro were investigated at different concentrations (0, 6.25, 12.5, 25, 50, and 100 μg/mL) of DADS using...
    Published on: 15 Jul 2015
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  • Case Report

    Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib: a case report and literature review

    Kenneth Siu Ho Chok , Ian Yu Hong Wong , See Ching Chan , Ronnie Tung Ping Poon , Chung Mau Lo
    Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) invasion and metastatic lymph node metastases has a poor prognosis, and surgical resection is seldom indicated. We report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor thrombosis in the IVC was successfully downstaged and ultimately resected together with the IVC. After the disease had been downstaged, curative resection of the tumor and IVC was conducted with immediate reconstruction of the IVC. The patient has survived for more than 2 years after the surgery. In...
    Published on: 15 Jul 2015
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  • Original Article

    Salvage transplantation for post-resection recurrence in hepatocellular carcinoma associated with hepatitis C virus etiology: a feasible strategy?

    Bhavin Bhupendra Vasavada , Chao-Long Chan
    Aim: The aim was to analyze the feasibility of salvage liver transplant after liver resection in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) etiology. Methods: All the patients diagnosed with HCC with HCV etiology who underwent living donor liver transplant from July 2002 to November 2012 were studied. Their recurrence rate, mortality, and prognostic factors were analyzed and compared between primary transplant and salvage transplant for up to 5 years post-transplant. Results: One hundred and nine patients underwent a liver transplant for HCC associated with HCV etiology...
    Published on: 15 Apr 2015
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  • Editorial

    The evolving role of transarterial chemoembolization in themanagement of hepatocellular carcinoma

    Georgios Tsoulfas
    Published on: 15 Apr 2015
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  • Original Article

    Repeat liver surgery by laparoscopy for a malignant recurrence after previous open or laparoscopic resection

    Luigi Cioffi , Andrea Belli , Corrado Fantini , Alberto D'Agostino , Gianluca Russo , Giulio Belli
    Aim: This paper reported the experience of one center on repeat laparoscopic liver surgery for metastasis and hepatocellular carcinoma (HCC) with a review of the literature. Methods: This retrospective study included 24 patients who underwent laparoscopic re-intervention (hepatic resection and radiofrequency ablation) for recurrent HCC in cirrhosis (n = 17) and for recurrent malignant metastases (n = 7) after a previous open or laparoscopic procedure. Patients were divided into two groups according to the first surgical approach. Group 1 underwent open resection and laparoscopic procedure...
    Published on: 15 Apr 2015
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  • Editorial

    Laparoscopic hepatectomy in cirrhotic patients with hepatocellular carcinoma: technical aspects and potential benefits

    Osamu Itano , Takuya Minagawa , Yuko Kitagawa
    Published on: 15 Apr 2015
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  • Original Article

    Role of diabetes mellitus on the recurrence rate of hepatocellular carcinomas after radiofrequency ablation in chronic hepatitis C patients

    Abd Allah Ahmed El-Sawy , Mohamed Abd El-Raouf Tawfik
    Aim: The aim was to assess the impact of hyperglycemia on the recurrence of hepatocellular carcinoma (HCC) as well as evaluate survival after curative ablation by radiofrequency. Methods: This study, which was conducted retrospectively on 107 chronic hepatitis C (CHC) patients with 159 HCCs, was presented to the Hepatology Unit of Internal Medicine Department at Tanta University Hospitals. All lesions were curatively treated by radiofrequency ablation (RFA) and the surveillance of HCC recurrence was evaluated radiologically every 3 months for periods between 6 and 36 months. Of 107...
    Published on: 15 Apr 2015
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  • Case Report

    Successful living donor liver transplantation in a cystic fibrosis patient with combined hepatocellular carcinoma and cholangiocarcinoma

    Falk Rauchfuß , Felix Dondorf , René Fahrner , Michael Ardelt , Yves Dittmar , Utz Settmacher
    Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is a rare tumor entity. In this report, we describe a case of a young patient who developed a liver tumor in a cirrhotic liver caused by cystic fibrosis. All diagnostic findings suggested that this tumor was an HCC. We performed living donor liver transplantation. Histological examination of the tumor revealed combined HCC and CC as an incidental finding. Two years after the transplantation, the patient is in good clinical condition and is disease-free.
    Published on: 15 Apr 2015
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  • Editorial

    Hepatoma Research: the beginning of a new forum

    Joseph F. Buell
    Published on: 15 Apr 2015
    [HTML]   [PDF]   Viewed:6904   Downloaded:163
  • Review

    Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease

    Kevin M. Sokolowski , Mariappan Balamurugan , Selvi Kunnimalaiyaan , T. Clark Gamblin , Muthusamy Kunnimalaiyaan
    The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base. One such cancer, primary liver cancer, is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative modalities. As a result, hepatocellular carcinoma (HCC), representing the majority of primary liver cancer, is the third most common cause of cancer-related deaths globally. Survival rates are linked to stage of presentation as well as concomitant cirrhosis limiting the 5-year survival in these patients to...
    Published on: 15 Apr 2015
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  • Original Article

    Combined radiofrequency and chemoembolization vs. chemoembolization in management of hepatocellular carcinoma

    Ahmed Kamal El Dorry , Eman Mahmoud Fathy Barakat , Amal Tohamy Abd ElMoez , Mervat Abd Fatah Mawad , Nevien Fouad El-Fouly , Mohamed Kamal Shaker
    Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. If left untreated, liver cancer has a poor prognosis with more than 90% of patients dying of the disease within 5 years of diagnosis. The aim of this study is to assess the value of combined radiofrequency ablation (RFA), followed by trans-arterial chemoembolization (TACE) in the management of HCC. Methods: Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment: 25 HCC patients treated with RFA followed by TACE within 5 days and 25...
    Published on: 15 Apr 2015
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  • Case Report

    Combined sarcomatoid hepatocellular and cholangiocarcinoma: a case report and literature review

    Julian Shun Tsang , Kenneth Siu Ho Chok , Rex Kwok Him Au-Yeung , Chung Mau Lo
    Hepatic sarcomatoid carcinomas are very rare. The majority of cases contain sarcomatoid features with either hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) elements alone. These are aggressive tumors and carry an unfavorable prognosis. We describe an extremely rare tumor sub-type of combined sarcomatoid HCC and CC in a hepatitis B virus carrier presenting with abdominal pain. Pre-operative imaging suggested a segment VI hepatocellular cancer with no metastatic spread. En bloc surgical resection with the right adrenal gland, Gerota's fascia and right hemidiaphragm was performed....
    Published on: 15 Apr 2015
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