Articles
  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a... Read more
    Hepatoma Res 2015;1:147-54. | doi:10.4103/2394-5079.167376
    Published on: 15 Oct 2015  | Viewed:6307  | Downloaded:279
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with... Read more
    Hepatoma Res 2015;1:136-46. | doi:10.4103/2394-5079.167377
    Published on: 15 Oct 2015  | Viewed:6208  | Downloaded:163
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were... Read more
    Hepatoma Res 2015;1:125-35. | doi:10.4103/2394-5079.167375
    Published on: 15 Oct 2015  | Viewed:7981  | Downloaded:270
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor... Read more
    Hepatoma Res 2015;1:119-24. | doi:10.4103/2394-5079.167379
    Published on: 15 Oct 2015  | Viewed:5441  | Downloaded:293
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases... Read more
    Hepatoma Res 2015;1:111-8. | doi:10.4103/2394-5079.167378
    Published on: 15 Oct 2015  | Viewed:6005  | Downloaded:407
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  • Review|Open Access

    “PERISH” flowchart for selection of the patients with resectable hepatocellular carcinoma

    Cuneyt Kayaalp , H. Kerem Tolan , Mehmet Caglikulekci
    A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms/staging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always diffi culties in remembering and/or recalling the contents of... Read more
    Hepatoma Res 2015;1:165-70. | doi:10.4103/2394-5079.161329
    Published on: 15 Oct 2015  | Viewed:17513  | Downloaded:255
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Hepatoma Res 2015;1:109-10. | doi:10.4103/2394-5079.161332
    Published on: 15 Oct 2015  | Viewed:40759  | Downloaded:199
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  • Review|Open Access

    Microwave coagulation therapy of hepatocellular carcinoma

    Yong-Song Guan
    Microwave coagulation therapy (MCT) is a relatively new method of tumor ablation compared to other minimally invasive local therapies for hepatocellular carcinoma (HCC). It is a thermal ablation modality based on the application of heat, potentially leading to larger ablation zones. In recent... Read more
    Hepatoma Res 2015;1:159-64. | doi:10.4103/2394-5079.164648
    Published on: 15 Oct 2015  | Viewed:6817  | Downloaded:220
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Hepatoma Res 2015;1:107-8. | doi:10.4103/2394-5079.161626
    Published on: 15 Oct 2015  | Viewed:4661  | Downloaded:114
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  • Review|Open Access

    Expectations for partial splenic arterial embolization simultaneous transcatheter arterial chemoembolization for hepatocellular carcinoma

    Toru Ishikawa
    Hepatocellular carcinoma (HCC) is frequently complicated by cirrhosis, and it is not unusual for treatment options to be limited as a result of pancytopenia due to hypersplenism. Partial splenic embolization (PSE) has been performed for thrombocytopenia resulting from hypersplenism. However, the... Read more
    Hepatoma Res 2015;1:155-8. | doi:10.4103/2394-5079.161284
    Published on: 15 Oct 2015  | Viewed:7026  | Downloaded:140
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  • Original Article|Open Access

    Sorafenib suppresses hepatitis B virus gene expression via inhibiting JNK pathway

    Hyun Kook Cho , Ju Ran Kim , So Young Kim , Yi Yi Kyaw , Aye Aye Win , Jae Hun Cheong
    Aim: Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases. Sorafenib is a multikinase inhibitor and an approved anti-liver cancer drug. Here we demonstrated the antiviral effect of sorafenib on HBV gene expression. Methods: To investigate the effect of sorafenib on HBV... Read more
    Hepatoma Res 2015;1:97-103. | doi:10.4103/2394-5079.158391
    Published on: 15 Jul 2015  | Viewed:8053  | Downloaded:97
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  • Original Article|Open Access

    Long-term immune-modulatory side effects of radiofrequency ablation in patients with liver metastases and hepatocellular carcinoma

    Thaddeus Till Wissniowski , Thomas Gress , Pietro Di Fazio
    Aim: Used as a palliative therapy for unresectable liver cancer, radiofrequency ablation (RFA) is associated with the induction of immunological responses. Here, we show strong evidence of tumor-specific peripheral blood mononuclear cells (PBMCs) 12 months after RFA. Methods: Three patients with... Read more
    Hepatoma Res 2015;1:92-6. | doi:10.4103/2394-5079.158024
    Published on: 15 Jul 2015  | Viewed:6830  | Downloaded:92
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  • Editorial|Open Access

    Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique?

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Hepatoma Res 2015;1:52-7. | doi:10.4103/2394-5079.155697
    Published on: 15 Jul 2015  | Viewed:7127  | Downloaded:258
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  • Original Article|Open Access

    Laparoscopic radiofrequency ablation for hepatocellular carcinoma

    Anna Sánchez-López , Anna Pallisera-Lloveras , Ramon Saiz-Mendiguren , Manuel Ferrer-Marsal , José Carlos Vicens-Arbona , José Andrés Cifuentes-Ródenas , Jose Manuel Ramia
    Aim: The optimal treatment for hepatocellular carcinoma (HCC) is either surgical resection or liver transplantation, but only one-third of the patients are suitable candidates for surgery. Laparoscopic radiofrequency ablation (RFA) in selected patients is a safe, feasible technique, which has... Read more
    Hepatoma Res 2015;1:86-91. | doi:10.4103/2394-5079.157692
    Published on: 15 Jul 2015  | Viewed:7991  | Downloaded:105
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  • Editorial|Open Access

    Preneoplastic foci in mice fed diethyl 1, 4-dihydro, 1, 4, 6-trimethyl 3, 5-pyridine decarboxylate are resistant to protoporphyrin accumulation

    Samuel W. French , M. Waheed Roomi
    Hepatoma Res 2015;1:50-1. | doi:10.4103/2394-5079.155984
    Published on: 15 Jul 2015  | Viewed:5293  | Downloaded:92
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  • Review|Open Access

    Hepatoma and trematode infestation: a short review

    Viroj Wiwanitkit
    Hepatoma is a common cancer that can be seen around the world and clinical correlation between infection and hepatoma is evident. Hepatitis virus infection is proved for its relationship with hepatoma. However, the knowledge of other infections is still limited. In this short review, the... Read more
    Hepatoma Res 2015;1:63-6. | doi:10.4103/2394-5079.158390
    Published on: 15 Jul 2015  | Viewed:6399  | Downloaded:76
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  • Original Article|Open Access

    Aqueous extract of Corchorus olitorius decreases cytotoxicity of aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Afl atoxin B1 (AFB1) and fumonisin B1 (FB1) are important food-borne mycotoxins. Co-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to... Read more
    Hepatoma Res 2015;1:75-85. | doi:10.4103/2394-5079.155692
    Published on: 15 Jul 2015  | Viewed:8169  | Downloaded:165
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  • Editorial|Open Access

    The evolving role of laparoscopic ablation

    Joseph F. Buell
    Hepatoma Res 2015;1:49. | doi:10.4103/2394-5079.159519
    Published on: 15 Jul 2015  | Viewed:6123  | Downloaded:95
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  • Review|Open Access

    Hepatocellular carcinoma in elderly patients: a concise review on systemic therapy with sorafenib

    Lombardi Giuseppe , Vitale Alessandro , Sara Lonardi , Bellu Luisa , Pambuku Ardi , Marsico Valentina , Crivellari Gino , Aliberti Camillo , Cillo Umberto , Zagonel Vittorina
    The treatment of hepatocellular carcinoma (HCC) in elderly patients is unclear. In particular, the efficacy and safety of sorafenib as a systemic treatment in these patients is still under debate. We performed a concise review of sorafenib therapy in this population. However, it is important to... Read more
    Hepatoma Res 2015;1:58-62. | doi:10.4103/2394-5079.157695
    Published on: 15 Jul 2015  | Viewed:7318  | Downloaded:149
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  • Original Article|Open Access

    Anti-proliferative and apoptotic effificacy of diallyl disulfide on Ehrlich ascites carcinoma

    Osama M. Ahmed , Rasha R. Ahmed
    Aim: This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfide (DADS) against Ehrlich ascites carcinoma (EAC) and to suggest its probable mechanism of action. Methods: EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock... Read more
    Hepatoma Res 2015;1:67-74. | doi:10.4103/2394-5079.157602
    Published on: 15 Jul 2015  | Viewed:9263  | Downloaded:191
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  • Case Report|Open Access

    Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib: a case report and literature review

    Kenneth Siu Ho Chok , Ian Yu Hong Wong , See Ching Chan , Ronnie Tung Ping Poon , Chung Mau Lo
    Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) invasion and metastatic lymph node metastases has a poor prognosis, and surgical resection is seldom indicated. We report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor... Read more
    Hepatoma Res 2015;1:104-6. | doi:10.4103/2394-5079.155694
    Published on: 15 Jul 2015  | Viewed:5155  | Downloaded:131
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  • Original Article|Open Access

    Salvage transplantation for post-resection recurrence in hepatocellular carcinoma associated with hepatitis C virus etiology: a feasible strategy?

    Bhavin Bhupendra Vasavada , Chao-Long Chan
    Aim: The aim was to analyze the feasibility of salvage liver transplant after liver resection in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) etiology. Methods: All the patients diagnosed with HCC with HCV etiology who underwent living donor liver transplant from July 2002 to... Read more
    Hepatoma Res 2015;1:36-40. | doi:10.4103/2394-5079.152916
    Published on: 15 Apr 2015  | Viewed:7810  | Downloaded:143
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  • Editorial|Open Access

    The evolving role of transarterial chemoembolization in themanagement of hepatocellular carcinoma

    Georgios Tsoulfas
    Hepatoma Res 2015;1:9-10. | doi:10.4103/2394-5079.153287
    Published on: 15 Apr 2015  | Viewed:5651  | Downloaded:90
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  • Original Article|Open Access

    Repeat liver surgery by laparoscopy for a malignant recurrence after previous open or laparoscopic resection

    Luigi Cioffi , Andrea Belli , Corrado Fantini , Alberto D'Agostino , Gianluca Russo , Giulio Belli
    Aim: This paper reported the experience of one center on repeat laparoscopic liver surgery for metastasis and hepatocellular carcinoma (HCC) with a review of the literature. Methods: This retrospective study included 24 patients who underwent laparoscopic re-intervention (hepatic resection and... Read more
    Hepatoma Res 2015;1:30-5. | doi:10.4103/2394-5079.153915
    Published on: 15 Apr 2015  | Viewed:7669  | Downloaded:160
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  • Editorial|Open Access

    Laparoscopic hepatectomy in cirrhotic patients with hepatocellular carcinoma: technical aspects and potential benefits

    Osamu Itano , Takuya Minagawa , Yuko Kitagawa
    Hepatoma Res 2015;1:6-8. | doi:10.4103/2394-5079.153786
    Published on: 15 Apr 2015  | Viewed:5676  | Downloaded:100
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  • Original Article|Open Access

    Role of diabetes mellitus on the recurrence rate of hepatocellular carcinomas after radiofrequency ablation in chronic hepatitis C patients

    Abd Allah Ahmed El-Sawy , Mohamed Abd El-Raouf Tawfik
    Aim: The aim was to assess the impact of hyperglycemia on the recurrence of hepatocellular carcinoma (HCC) as well as evaluate survival after curative ablation by radiofrequency. Methods: This study, which was conducted retrospectively on 107 chronic hepatitis C (CHC) patients with 159 HCCs, was... Read more
    Hepatoma Res 2015;1:24-9. | doi:10.4103/2394-5079.154356
    Published on: 15 Apr 2015  | Viewed:7248  | Downloaded:123
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  • Case Report|Open Access

    Successful living donor liver transplantation in a cystic fibrosis patient with combined hepatocellular carcinoma and cholangiocarcinoma

    Falk Rauchfuß , Felix Dondorf , René Fahrner , Michael Ardelt , Yves Dittmar , Utz Settmacher
    Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is a rare tumor entity. In this report, we describe a case of a young patient who developed a liver tumor in a cirrhotic liver caused by cystic fibrosis. All diagnostic findings suggested that this tumor was an HCC. We performed... Read more
    Hepatoma Res 2015;1:46-8. | doi:10.4103/2394-5079.153288
    Published on: 15 Apr 2015  | Viewed:5047  | Downloaded:106
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  • Editorial|Open Access

    Hepatoma Research: the beginning of a new forum

    Joseph F. Buell
    Hepatoma Res 2015;1:1-5. | doi:10.4103/2394-5079.153290
    Published on: 15 Apr 2015  | Viewed:7260  | Downloaded:167
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  • Review|Open Access

    Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease

    Kevin M. Sokolowski , Mariappan Balamurugan , Selvi Kunnimalaiyaan , T. Clark Gamblin , Muthusamy Kunnimalaiyaan
    The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base. One such cancer, primary liver cancer, is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative... Read more
    Hepatoma Res 2015;1:11-8. | doi:10.4103/2394-5079.154132
    Published on: 15 Apr 2015  | Viewed:9747  | Downloaded:274
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  • Original Article|Open Access

    Combined radiofrequency and chemoembolization vs. chemoembolization in management of hepatocellular carcinoma

    Ahmed Kamal El Dorry , Eman Mahmoud Fathy Barakat , Amal Tohamy Abd ElMoez , Mervat Abd Fatah Mawad , Nevien Fouad El-Fouly , Mohamed Kamal Shaker
    Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. If left untreated, liver cancer has a poor prognosis with more than 90% of patients dying of the disease within 5 years of diagnosis. The aim of this study is to assess the value of combined radiofrequency... Read more
    Hepatoma Res 2015;1:19-23. | doi:10.4103/2394-5079.154355
    Published on: 15 Apr 2015  | Viewed:7200  | Downloaded:160
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  • Case Report|Open Access

    Combined sarcomatoid hepatocellular and cholangiocarcinoma: a case report and literature review

    Julian Shun Tsang , Kenneth Siu Ho Chok , Rex Kwok Him Au-Yeung , Chung Mau Lo
    Hepatic sarcomatoid carcinomas are very rare. The majority of cases contain sarcomatoid features with either hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) elements alone. These are aggressive tumors and carry an unfavorable prognosis. We describe an extremely rare tumor sub-type of... Read more
    Hepatoma Res 2015;1:41-5. | doi:10.4103/2394-5079.154331
    Published on: 15 Apr 2015  | Viewed:7165  | Downloaded:168
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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