Latest
  • Review|Open Access

    Chitinase-3-like protein 1 as a predictor for the progression or regression of liver fibrosis

    Biaoyang Lin, Shengjun Wu, Yunhua Liu, Longgen Liu, Saadiya Mushtaq
    Liver fibrosis is a wound-healing response of liver cells to chronic injuries caused by viral infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), toxins, and alcohol abuse. The ability to stage diseases for treatment naïve patients to initiate proper medical procedures and predict the clinical causes of the disease or the treatment response is important given the increased prevalence of liver fibrosis caused by HBV, HCV and fatty liver diseases. CHI3L1 (chitinase-3-like protein 1, also known as YKL-40), which belongs to the chitinase family but lacks chitinolytic... Read more
    Hepatoma Res 2018;4:48. | doi:10.20517/2394-5079.2018.19
    Published on: 17 Aug 2018  | Viewed:45  | Downloaded:3
    +HTML| PDF
  • Review|Open Access

    Laparoscopic liver resection for hepatocellular carcinoma

    Massimo Giacca, Daniel Cherqui
    Hepatocellular carcinoma (HCC) represents the most common indication of laparoscopic liver resection (LLR). It must be acknowledged that most series concern minor hepatectomies for peripheral lesions located in favorable segments, and such procedures are now performed in the majority of HPB centers. However, there are growing reports concerning major hepatectomies (i.e., 3 segments or more) and complex resections such as anatomical resections in difficult segments (i.e., postero-superior). Retrospective comparative studies, including some with propensity score matching, and meta-analyses... Read more
    This article belongs to the Special Issue Management of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:47. | doi:10.20517/2394-5079.2018.79
    Published on: 17 Aug 2018  | Viewed:55  | Downloaded:2
    +HTML| PDF
  • Review|Open Access

    Screening for hepatocellular carcinoma: summary of current guidelines up to 2018

    Nevin Yilmaz, Ugur Eser Yilmaz, Kaya Suer, Vedat Goral, Nedim Cakir
    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related to worldwide death with a great geographical variation. To be eligible for curative therapy at the time of diagnosis is important. However, the majority of cases are diagnosed at late stages. This can be achieved with applicable screening modalities. Until now, many organizations around the world have developed guidelines according to their own evidence-based data for screening of HCC. The purpose of this article is to review the screening modalities of HCC to assist gastroenterologists and providers involved in... Read more
    This article belongs to the Special Issue What More We can do on Hepatitis C?
    Hepatoma Res 2018;4:46. | doi:10.20517/2394-5079.2018.49
    Published on: 16 Aug 2018  | Viewed:35  | Downloaded:5
    +HTML| PDF
  • Opinion|Open Access

    Elimination of hepatitis from Pakistan by 2030: is it possible?

    Yasir Waheed, Masood Siddiq
    Globally 71 million people are living with hepatitis C virus (HCV) out which 7.1 million (10%) are present in Pakistan. Genotype 3 is the most common HCV type in the country. World Health Organization is working with health authorities in different countries for effective control of HCV, to reduce its incidence by 90% and to reduce hepatitis related mortality by 65% by the year 2030. There are several challenges that hinder elimination of HCV from Pakistan including the lack of patient awareness about the causes and transmission of disease, lack of affordability for investigations and drug... Read more
    This article belongs to the Special Issue What More We can do on Hepatitis C?
    Hepatoma Res 2018;4:45. | doi:10.20517/2394-5079.2018.58
    Published on: 14 Aug 2018  | Viewed:232  | Downloaded:6
    +HTML| PDF
  • Review|Open Access

    Exosome-based liquid biopsy in the management of hepatocellular carcinoma

    Aparna Jayachandran, Sasidhar Venkata Manda, Ritu Shrestha, Kim R. Bridle, Prashanth Prithviraj, Darrell H. G. Crawford
    Hepatocellular carcinoma (HCC) commonly presents at an advanced stage due to the lack of efficient early screening tools. Early, non-invasive biomarkers useful in the diagnosis and prognosis of HCC would be of significant benefit for HCC management. Development of exosome-based liquid biopsy as a non-invasive method for the management of HCC has gained much traction. Exosomes are small membranous vesicles secreted by most cell types including HCC cells. Exosomes serve as couriers for the intercellular transfer of important biomolecules, including, protein, nucleic acids and lipids to nearby... Read more
    This article belongs to the Special Issue Management of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:44. | doi:10.20517/2394-5079.2018.59
    Published on: 13 Aug 2018  | Viewed:84  | Downloaded:9
    +HTML| PDF
  • Review|Open Access

    Factors predicting hepatocellular carcinoma in hepatitis C infection

    Zaigham Abbas, Minaam Abbas
    Hepatitis C virus (HCV) has emerged as a leading cause of hepatocellular carcinoma (HCC). In most cases, the virus causes HCC in the presence of chronic hepatic inflammation, advanced fibrosis, and cirrhosis. A combination of viral, environmental, and genetic factors are likely to determine the host immune response to the infection as well as the progression to HCC. Clinical and epidemiologic studies have identified many of the risk factors associated with HCC development in patients with chronic hepatitis C. Male sex and older age are considered as independent risk factors for HCC, while... Read more
    This article belongs to the Special Issue What More We can do on Hepatitis C?
    Hepatoma Res 2018;4:43. | doi:10.20517/2394-5079.2018.26
    Published on: 8 Aug 2018  | Viewed:109  | Downloaded:6
    +HTML| PDF
  • Review|Open Access

    Molecular mechanism of hepatocellular carcinoma

    Seung Kew Yoon
    Development of hepatocellular carcinoma (HCC) is very complex and occurs through a multistep biological process of malignant transformation of normal hepatocytes in which various factors, including genetic and epigenetic alterations, regulation of oxidative stress, inflammation, and immunity are involved. To date, numerous studies have described the molecular pathogenesis of HCC, but the precise molecular mechanisms of HCC development remain unclear. Emerging single-cell transcriptome analysis technology is a powerful tool for defining sub-populations within heterogeneous bulk tumor tissue... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:42. | doi:10.20517/2394-5079.2018.23
    Published on: 8 Aug 2018  | Viewed:194  | Downloaded:32
    +HTML| PDF
  • Original Article|Open Access

    Heat shock reduces HCV replication via regulation of ribosomal L22 in Alu-RNA molecule dependent manner

    Hamada Farghaly, Adel A. Guirgis, Hany Khalil
    ... Read more
    This article belongs to the Special Issue What More We can do on Hepatitis C?
    Hepatoma Res 2018;4:41. | doi:10.20517/2394-5079.2018.30
    Published on: 7 Aug 2018  | Viewed:162  | Downloaded:13
    +HTML| PDF
  • Review|Open Access

    Immunotherapy: a new era for hepatocellular carcinoma

    Ya-Jing He, Ya-Bing Guo, Wei Zhu, Yu-Kai He, Jin-Lin Hou
    Cancer is a major disease threatening human health. The overall prognosis for hepatocellular carcinoma (HCC) patients is poor, with a dismal 5-year survival rate of approximately 5%-30%. The dysfunction of immune system plays a pivotal role in the development of cancer, which has attracted attention of several researchers. Recent advances in immunotherapy have led to various inspired achievements and refreshed our concepts about cancer treatments. In this article, several types of immune-based therapies for treating HCC are reviewed. Their underlying mechanisms, preclinical and clinical... Read more
    Hepatoma Res 2018;4:40. | doi:10.20517/2394-5079.2018.45
    Published on: 6 Aug 2018  | Viewed:273  | Downloaded:8
    +HTML| PDF
  • Review|Open Access

    Oxidative stress and hepatocarcinogenesis

    Ying Fu, Fung-Lung Chung
    Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. There are two major challenges for HCC, the first being that early detection is generally not applicable, and secondly, it is usually fatal within several months after diagnosis. HCC is an inflammation-induced cancer. It is known that chronic inflammation leads to oxidative/nitrosative stress and lipid peroxidation, generating excess oxidative stress, together with aldehydes which can react with DNA bases to form promutagenic DNA adducts. In this review, the evidence between oxidative stress and... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:39. | doi:10.20517/2394-5079.2018.29
    Published on: 1 Aug 2018  | Viewed:589  | Downloaded:79
    +HTML| PDF
  • Review|Open Access

    Fat and hepatocellular carcinoma

    Clara Balsano, Cristiana Porcu, Silvia Sideri, Simona Tavolaro
    Obesity and diabetes are associated with the onset of hepatocellular carcinoma (HCC). These two illnesses correlate also with the development of non-alcoholic fatty liver disease (NAFLD). Currently, NAFL is considered the leading form of chronic liver disease in the Western industrialized countries. Insulin resistance is the common pathogenic factor among these three pathologies. NAFL is characterized by fat accumulation in the liver that involves greater than 5% of the liver parenchyma with no evidence of hepatocyte injury. However, NAFL may progress toward non-alcoholic steatohepatitis... Read more
    This article belongs to the Special Issue New Insights in Liver Cancer
    Hepatoma Res 2018;4:38. | doi:10.20517/2394-5079.2018.51
    Published on: 25 Jul 2018  | Viewed:767  | Downloaded:106
    +HTML| PDF
  • Review|Open Access

    Aberrant pre-mRNA splicing regulation in the development of hepatocellular carcinoma

    Supriya Sen
    Alternative splicing is a highly regulated process that plays a critical role in diversification of the transcriptome and proteome in the cell. Several diseases, including different types of cancers, have been associated with aberrant regulation of alternative splicing. Thus, correcting alternative splicing is an attractive strategy to restore normal cell physiology in patients with cancer including hepatocellular carcinoma (HCC). This review summarizes the role of alternative splicing events related to HCC and potential therapeutic applications for it. Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:37. | doi:10.20517/2394-5079.2018.39
    Published on: 18 Jul 2018  | Viewed:175  | Downloaded:6
    +HTML| PDF
  • Review|Open Access

    Hepatitis C related hepatocellular carcinoma in the era of direct-acting antivirals

    Akshata Moghe, Obaid S. Shaikh
    Globally, hepatocellular carcinoma (HCC) is the second leading cause of cancer related death. Hepatitis C virus infected patients with cirrhosis or bridging fibrosis are particularly at risk. The risk is reduced among patients who achieve viral clearance with interferon-based regimens. Direct-acting antivirals (DAA) have revolutionized the management of HCV as the treatment is well tolerated, convenient to administer and is highly effective. Earlier studies showed conflicting results in the effect of DAA induced sustained virologic response (SVR) on the subsequent development or recurrence... Read more
    This article belongs to the Special Issue What More We can do on Hepatitis C?
    Hepatoma Res 2018;4:36. | doi:10.20517/2394-5079.2018.54
    Published on: 18 Jul 2018  | Viewed:243  | Downloaded:16
    +HTML| PDF
  • Original Article|Open Access

    [18F]FDG PET imaging evaluation on non-alcoholic fatty liver disease and hepatocellular carcinoma model treated with sorafenib

    Fernando Gomes de Barros Costa, José Tadeu Stefano, Daniele de Paula Faria, Caio de Souza Levy, Maria Cristina Chammas, Camila de Godoi Carneiro, Isabel Veloso Alves Pereira, Bruno Cogliati, Flair José Carrilho, Claudia P. Oliveira
    Aim: Evaluate the effect of sorafenib in a rat model of non-alcoholic fatty liver disease (NAFLD) related to hepatocellular carcinoma (HCC) by quantifying the correlation between changes in glucose metabolism on PET imaging and degree of tumor differentiation. Methods: NAFLD related HCC was induced by the combination of high fat and choline deficient diet with diethylnitrosamine (100 mg/L) for 16 weeks. Then carcinogenic stimuli were suspended, liver nodules were identified by abdominal ultrasound and two groups were randomized: control (n = 10) and sorafenib (n = 20). Rats received daily... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:35. | doi:10.20517/2394-5079.2018.06
    Published on: 12 Jul 2018  | Viewed:294  | Downloaded:12
    +HTML| PDF
  • Review|Open Access

    Somatostatin in hepatocellular carcinoma: experimental and therapeutic implications

    Elias Kouroumalis, Demetrius Samonakis, George Notas
    The neuropeptide somatostatin has been shown to control the secretion of several hormones and growth factors, but also to inhibit the proliferation of several tumor cells. Hepatocellular carcinoma (HCC) is a leading cause of death all over the world due to very limited treatment modalities. Early reports showed that somatostatin may influence HCC growth, making somatostatin a potential therapeutic candidate. The introduction of somatostatin analogues with long half-lives has made this prospect feasible. In this review, experimental data regarding the presence of somatostatin receptors and... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:34. | doi:10.20517/2394-5079.2018.33
    Published on: 11 Jul 2018  | Viewed:169  | Downloaded:17
    +HTML| PDF
  • Review|Open Access

    Living donor liver transplantation for patients with hepatocellular carcinoma in Japan

    Yasuhiko Sugawara, Hidekazu Yamamoto, Taizo Hibi
    Liver transplantation has now been an established treatment for hepatocellular carcinoma and cirrhosis. The Milan criteria have been accepted and applied widely in the world as an indication for deceased donor liver transplant. Due to the severe organ shortage, however, living donor liver transplant (LDLT) has accounted for the majority of transplantations in Japan and the other Asian countries/regions. LDLT cannot be limited by the restrictions imposed by the allocation system but depends on institutional criterion or case-by-case considerations. Accumulating data from a nationwide survey... Read more
    This article belongs to the Special Issue Management of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:33. | doi:10.20517/2394-5079.2018.69
    Published on: 10 Jul 2018  | Viewed:202  | Downloaded:9
    +HTML| PDF
  • Review|Open Access

    The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

    Saranya Chidambaranathan-Reghupaty, Rachel Mendoza, Paul B. Fisher, Devanand Sarkar
    Staphylococcal nuclease and tudor domain containing 1 (SND1) is a protein that regulates a complex array of functions. It controls gene expression through transcriptional activation, mRNA degradation, mRNA stabilization, ubiquitination and alternative splicing. More than two decades of research has accumulated evidence of the role of SND1 as an oncogene in various cancers. It is a promoter of cancer hallmarks like proliferation, invasion, migration, angiogenesis and metastasis. In addition to these functions, it has a role in lipid metabolism, inflammation and stress response. The... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:32. | doi:10.20517/2394-5079.2018.34
    Published on: 10 Jul 2018  | Viewed:199  | Downloaded:8
    +HTML| PDF
  • Review|Open Access

    Performance of different biomarkers for the management of hepatocellular carcinoma

    Ángela Rojas, Yolanda Sánchez-Torrijos, Antonio Gil-Gómez, Chang-Hai Liu, Clara Rodríguez-Rivas, María Teresa Ferrer, Manuel Romero-Gómez
    Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the second cause of cancer related death due to latent liver disease, late diagnosis and non-available therapeutic treatment. Liver biopsy is still the gold standard in order to know the molecular biology of the tumor, its behaviour and invasive characteristics. Conventional diagnosis methods for HCC detection include imaging and serological tests with low sensitivity and specificity. In this review, we focus on the potential utility of certain serum biomarkers and a new approach, “liquid biopsy”, in the management... Read more
    This article belongs to the Special Issue Molecular Mechanism of Hepatocellular Carcinoma
    Hepatoma Res 2018;4:31. | doi:10.20517/2394-5079.2018.60
    Published on: 6 Jul 2018  | Viewed:435  | Downloaded:60
    +HTML| PDF
  • Review|Open Access

    Oncogenic Wnt3a: a promising specific biomarker in hepatocellular carcinoma

    Min Yao, Miao Fang, Wen-Jie Zheng, Deng-Fu Yao
    Hepatocellular carcinoma (HCC) is still one of the most common and rapidly fatal malignancies worldwide with a multi-factorial, multi-step, complex process, and poor prognosis. Early discovery and effective therapy of HCC are of utmost importance. Recent studies demonstrated that Wnt/β-catenin pathway play important roles in occurrence and development of HCC including hepatocytes malignant transformation, metastasis, chemoresistance and liver cancer stem cells. Oncogenic wingless-type MMTV integration site family member 3a (Wnt3a) signaling is a promising biomarker in diagnosis and... Read more
    Hepatoma Res 2018;4:30. | doi:10.20517/2394-5079.2018.32
    Published on: 5 Jul 2018  | Viewed:182  | Downloaded:21
    +HTML| PDF
  • Review|Open Access

    Understanding the inflammation-cancer transformation in the development of primary liver cancer

    Hong-Jin Chen, Ming-Hua Hu, Fang-Gui Xu, Hao-Jun Xu, Jun-Jun She, Hong-Ping Xia
    Primary liver cancer is one of the leading causes of cancer-related deaths worldwide. China has more than 55% liver cancer cases globally. The development of hepatocellular carcinoma (HCC) was caused by a variety of risks factors, including chronic inflammation by virus, alcohol consumption and non-alcoholic steatohepatitis. Emerging evidence has notarized inflammation as a critical component of HCC progression. The development of HCC is a multistep process which may originate from liver chronic injury and inflammation to subsequent fibrosis and/or cirrhosis and finally HCC. A large number... Read more
    Hepatoma Res 2018;4:29. | doi:10.20517/2394-5079.2018.18
    Published on: 5 Jul 2018  | Viewed:627  | Downloaded:58
    +HTML| PDF
Hepatoma Research ISSN 2454-2520 (Online), ISSN 2394-5079 (Print)
Partners
Copyright © 2018 OAE Publishing Inc. All Rights Reserved.