Editor's Picks
  • Review

    Role of antiviral therapy in patients with chronic hepatitis B or C virus in preventing the development of hepatocellular carcinoma

    Laura Scribano , Veronica Vanin , Giorgia Gottardo , Diana Sacchi , Francesco Paolo Russo
    Patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are at significant risk for hepatocellular carcinoma (HCC). The most important risk factor associated with HCC is liver cirrhosis, which is again predominantly caused by chronic HBV or HCV infection. The most effective approach to avoid HCC development is to prevent HBV and HCV infection through vaccination. Indeed, HBV vaccine is the first vaccine demonstrated to prevent cancers. However, a vaccine for HCV is not available. Thus, the prevention of HCV-related...
    Published on: 15 Jan 2016
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  • Original Article

    Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

    Mohamed Ahmed Samy Kohla , Om Kolsoum Al-Haddad , Ali Nada , Mohamed Al-Warraky , Manar Obada , Mohamed Amer , Sameera Ezzat , Ashraf Abou Gabal
    Aim: Epidermal growth factor (EGF) is a mitogen for hepatocyte grown in vitro, and its expression is up-regulated during liver regeneration. EGF also plays an important role in tumor initiation and progression. The goal of this study is to assess whether EGF is associated with advanced hepatocellular carcinoma (HCC) and also whether it is a predictive factor of shortened survival. Methods: Serum EGF levels were evaluated in a total of 151 subjects: 51 patients with unresectable HCC, (21 of them were eligible for transarterial...
    Published on: 15 Jan 2016
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  • Original Article

    Aqueous extract of Corchorus olitorius decreases cytotoxicity of aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Afl atoxin B1 (AFB1) and fumonisin B1 (FB1) are important food-borne mycotoxins. Co-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to these mycotoxins in grain are greatest. The aim of the current study was to evaluate the potential protective effects of an aqueous extract of Cochorus olitorius (C. olitorius, moroheiya) against cytotoxicity of AFB1 and/or FB1 in H4IIE-luc rat...
    Published on: 15 Jul 2015
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  • Review

    Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease

    Kevin M. Sokolowski , Mariappan Balamurugan , Selvi Kunnimalaiyaan , T. Clark Gamblin , Muthusamy Kunnimalaiyaan
    The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base. One such cancer, primary liver cancer, is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative modalities. As a result, hepatocellular carcinoma (HCC), representing the majority of primary liver cancer, is the third most common cause of cancer-related deaths globally. Survival rates are linked to stage of presentation as well as concomitant cirrhosis...
    Published on: 15 Apr 2015
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