Articles
  • Original Article|Open Access

    Clinical outcomes of direct-acting antiviral therapy in patients with compensated hepatitis C virus-related cirrhosis

    Estefania Berge , Ana Arencibia , Elena Otón , Luis Cejas , Silvia Acosta , Francisco Pérez
    Aim: The aim was to assess the clinical impact of direct-acting antiviral treatment in patients with compensated hepatitis C virus-related cirrhosis after one year of follow-up. Methods: An observational retrospective study was conducted on 129 consecutive patients with compensated cirrhosis... Read more
    Hepatoma Res 2017;3:209-14. | doi:10.20517/2394-5079.2017.28
    Published on: 27 Sep 2017  | Viewed:126  | Downloaded:15
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  • Case Report|Open Access

    Total regression of hepatocellular carcinoma bone metastases, after liver transplantation, with sorafenib-everolimus

    Dimitrios Giakoustidis , Athanasios Apostolos Gargavanis , Nikolaos Salveridis , Evangelos Cholongitas , Emmanouil Sinakos , Konstantinos Papapolychroniadis , Vasileios Papanikolaou
    Hepatocellular carcinoma (HCC) represents the 5th commonest malignancy worldwide. Liver transplantation consist a radical and most efficient treatment for HCC. Tumor recurrence or metastases after liver transplantation is not uncommon. Hereby is presented a case of a patient transplanted for... Read more
    Hepatoma Res 2017;3:205-8. | doi:10.20517/2394-5079.2017.29
    Published on: 20 Sep 2017  | Viewed:175  | Downloaded:18
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  • Topic: Management of Huge and Advanced Hepatocellular Carcinoma|Open Access

    Outcomes of emergency and interval hepatectomy for ruptured resectable hepatocellular carcinoma: a single tertiary referral centre experience

    Andrew Kai Yip Fung , Charing Ching Ning Chong , Kit Fai Lee , John Wong , Yue Sun Cheung , Anthony Kwong Wai Fong , Paul Bo San Lai
    Aim: The short and long term outcomes of patients who underwent emergency and interval hepatectomy for ruptured and resectable hepatocellular carcinoma (HCC) were analysed. Methods: The data of patients with ruptured HCC presenting between April 2004 and October 2015 were analysed. Emergency... Read more
    Hepatoma Res 2017;3:196-204. | doi:10.20517/2394-5079.2017.23
    Published on: 8 Sep 2017  | Viewed:367  | Downloaded:30
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  • Topic: Management of Huge and Advanced Hepatocellular Carcinoma|Open Access

    Surgical strategy for huge and advanced hepatocellular carcinoma in Hong Kong

    Kenneth S.H. Chok
    In Hong Kong, surgical resection is the core curative treatment for huge and advanced hepatocellular carcinoma (HCC). For tumors measuring 10 cm or above, major hepatectomy is usually required, but a future liver remnant not large enough will preclude the operation. Hypertrophy of future liver... Read more
    Hepatoma Res 2017;3:189-95. | doi:10.20517/2394-5079.2017.33
    Published on: 3 Sep 2017  | Viewed:609  | Downloaded:45
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  • Original Article|Open Access

    Transcatheter arterial chemoembolization in recurrent unresectable hepatocellular carcinoma after orthotopic liver transplantation

    Hasmukh J. Prajapati , Pavan Kavali , Hyun S. Kim
    Aim: To investigate the survivals and efficacy of the doxorubicin drug eluting beads transcatheter arterial chemoembolization (TACE) in patients with recurrent hepatocellular carcinoma (HCC) status post orthotopic liver transplantation. Methods: Consecutive patients with HCC who underwent... Read more
    Hepatoma Res 2017;3:182-8. | doi:10.20517/2394-5079.2017.25
    Published on: 17 Aug 2017  | Viewed:321  | Downloaded:32
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  • Case Report|Open Access

    Hepatocellular carcinoma following direct anti-viral for hepatitis C treatment: a report of an Egyptian case series

    Eman A. Rewisha , Maha M. Elsabaawy , Omar Elshaarawy , Ayat Abdullah , Dalia M. Elsabaawy , Omkolsoum M. Alhaddad
    Egypt had been vexed by the highest load of chronic hepatitis C in the world. It represents a vast market of the new direct-acting anti-viral drugs (DAAs); effectively treating chronic hepatitis C virus (HCV) infection. Eradication of HCV in Egypt has been challenged by the observed increased... Read more
    Hepatoma Res 2017;3:178-81. | doi:10.20517/2394-5079.2017.18
    Published on: 11 Aug 2017  | Viewed:928  | Downloaded:133
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  • Original Article|Open Access

    Laparoscopic liver resection with lymph node dissection for gallbladder tumors suspected to be T1b/T2 carcinoma

    Masashi Isetani , Zenichi Morise , Akihiko Horiguchi
    Aim: The short-term perioperative results of laparoscopic treatment of gallbladder (GB) carcinoma were evaluated to determine whether this technique can be a feasible treatment option. Methods: Ten patients with fundus/body GB tumors (GBTs) underwent laparoscopic liver resection (LLR) and lymph... Read more
    Hepatoma Res 2017;3:170-7. | doi:10.20517/2394-5079.2017.17
    Published on: 9 Aug 2017  | Viewed:458  | Downloaded:34
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  • Topic: Advances in the diagnosis and treatment of liver fibrosis|Open Access

    Advances in the diagnosis and treatment of liver fibrosis

    Jenny Yeuk-Ki Cheng , Grace Lai-Hung Wong
    Liver fibrosis is the center of diagnosis and management of essentially all chronic liver diseases. While liver biopsy examination still has a role in diagnosis and drug development, it is replaced by non-invasive assessments of liver biopsy in majority of the clinical scenarios. Radiological... Read more
    Hepatoma Res 2017;3:156-69. | doi:10.20517/2394-5079.2017.27
    Published on: 8 Aug 2017  | Viewed:2321  | Downloaded:160
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  • Original Article|Open Access

    In vitro antitumor efficacy of Kochia indica extract on human hepatocellular carcinoma cell line with or without 5-fluorouracil

    Nabil Mohie Abdel-Hamid , Ghada A. Tabl , Yousry E. El-Bolkiny , Walaa O. Zeina
    Aim: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the sixth most common cancer worldwide. The resistance to chemotherapy is a major obstacle in the treatment of HCC, necessitating the discovery of additional agents. There is a growing use of anticancer... Read more
    Hepatoma Res 2017;3:149-55. | doi:10.20517/2394-5079.2016.50
    Published on: 21 Jul 2017  | Viewed:1901  | Downloaded:49
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  • Original Article|Open Access

    Response rates of hepatocellular carcinoma and hepatic colorectal cancer metastases to drug eluting bead regional liver therapy

    Glenn W. Stambo , Deborah Cragan
    Aim: The purpose of this study was to evaluate and compare how hepatocellular carcinoma (HCC) and colorectal metastases respond to LC Bead chemoembolization using doxorubicin and irinotecan. Methods: The authors report their experience with doxorubicin and irinotecan eluting beads to treat 13... Read more
    Hepatoma Res 2017;3:141-8. | doi:10.20517/2394-5079.2017.12
    Published on: 12 Jul 2017  | Viewed:432  | Downloaded:65
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  • Review|Open Access

    Function of myeloid cell leukaemia-1 and its regulative relations with hepatocellular carcinoma

    Man Zhu , Yan-Min Zhang
    Hepatocellular carcinoma (HCC) remains a challenging disease with a high recurrence rate after surgery and there is an imminent need to identify new treatments. Currently, adjuvant therapy like chemotherapeutics arises to counteract the malignant trait escaping from apoptosis of tumors induced by... Read more
    Hepatoma Res 2017;3:129-40. | doi:10.20517/2394-5079.2017.14
    Published on: 6 Jul 2017  | Viewed:521  | Downloaded:64
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  • Original Article|Open Access

    Use of gadobenate dimeglumine dynamic MRI for detection of early hepatocellular carcinoma in atypical hepatic focal lesions

    Mohamed F. El-Gazzar , Mohamed Ahmed Samy Kohla , Mahmoud M. El-Sakhawy , Mohamed M. Husseiny , Reda R. H. Yousef , Safinaz H. El-Shorbagy
    Aim: Gadobenate dimeglumine (multihance) is a contrast medium which can be used not only as an extracellular contrast agent for dynamic imaging of the liver, but also as a liver specific agent for the acquisition of hepatobiliary-phase images which are more helpful in evaluation of small atypical... Read more
    Hepatoma Res 2017;3:123-8. | doi:10.20517/2394-5079.2017.08
    Published on: 26 Jun 2017  | Viewed:951  | Downloaded:84
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  • Review|Open Access

    Management of advanced hepatocellular carcinoma: review of current and potential therapies

    Asmaa Gomaa , Imam Waked
    Over the past few years, despite improvement in screening and diagnosis of hepatocellular carcinoma (HCC), advanced stage remains the most common presentation at diagnosis, with limited management options, especially options available to patients in limited resource countries. There is currently... Read more
    Hepatoma Res 2017;3:112-22. | doi:10.20517/2394-5079.2017.03
    Published on: 15 Jun 2017  | Viewed:2679  | Downloaded:415
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  • Review|Open Access

    Roles of p53 in extrinsic factor-induced liver carcinogenesis

    Tim Link , Tomoo Iwakuma
    Liver cancer remains one of the most common human cancers with a high mortality rate. Therapies for hepatocellular carcinoma (HCC) remain ineffective, due to the heterogeneity of HCC with regard to both the etiology and mutation spectrum, as well as its chemotherapy resistant nature; thus... Read more
    Hepatoma Res 2017;3:95-104. | doi:10.20517/2394-5079.2017.07
    Published on: 6 Jun 2017  | Viewed:860  | Downloaded:65
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  • Original Article|Open Access

    Detection of urine DNA markers for monitoring recurrent hepatocellular carcinoma

    Hie-Won Hann , Surbhi Jain , Grace Park , Jamin D. Steffen , Wei Song , Ying-Hsiu Su
    Aim: This study aimed to explore the potential of detecting hepatocellular carcinoma (HCC)-associated DNA markers, TP53 249T mutations and aberrant methylation of RASSF1A and GSTP1 genes, for monitoring HCC recurrence. HCC remains a leading cause of death worldwide, with one of the fastest... Read more
    Hepatoma Res 2017;3:105-11. | doi:10.20517/2394-5079.2017.15
    Published on: 6 Jun 2017  | Viewed:1158  | Downloaded:141
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  • Case Report|Open Access

    First case report of inflammatory myofibroblastic tumor of peritoneal cavity in a living donor liver transplantation recipient

    Naganathan Selvakumar , Parul Saboti , Sumaid Kaul , Subash Gupta
    Post-transplantation malignancies are well known complications after liver transplantation. Certain malignancies are more common in pediatric recipients than adults. Inflammatory myofibroblastic tumors (IMTs) are reactive neoplasms with miniscule malignant potential. IMTs are more common after... Read more
    Hepatoma Res 2017;3:86-9. | doi:10.20517/2394-5079.2017.01
    Published on: 17 May 2017  | Viewed:402  | Downloaded:42
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  • Editorial|Open Access

    Liver transplantation in acute-on-chronic liver failure

    Roger Williams
    Hepatoma Res 2017;3:90-4. | doi:10.20517/2394-5079.2017.13
    Published on: 17 May 2017  | Viewed:1148  | Downloaded:87
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  • Original Article|Open Access

    MELD score and AST-to-platelet ratio index predict long-term survival in patients with a small hepatocellular carcinoma following non-transplant therapies: a pilot study

    Joy Sarkar , Thomas DeLeon , Linda L. Wong
    Aim: Liver transplantation (LT) is the most effective treatment for long-term survival from hepatocellular carcinoma (HCC); however, insufficient donors limit therapy. The authors sought to identify characteristics that predicted long-term survival after non-transplant therapies in patients with... Read more
    Hepatoma Res 2017;3:79-85. | doi:10.20517/2394-5079.2017.06
    Published on: 9 May 2017  | Viewed:886  | Downloaded:59
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  • Minireview|Open Access

    Primary hepatic lymphoma: is it a disease entity?

    Fei Xiong , Yong-Song Guan
    It is now widely accepted that lymphoma is a cancer of the lymphatic cells in the immune system and a type of blood cancer that develops when T or B lymphocytes of the white blood cells display uncontrolled proliferation and cellular immortality. Currently, a number of authors have published case... Read more
    Hepatoma Res 2017;3:73-8. | doi:10.20517/2394-5079.2017.02
    Published on: 9 May 2017  | Viewed:607  | Downloaded:48
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  • Minireview|Open Access

    Updates on hepatorenal syndrome and strategies bridging to liver transplantation

    Chung Yeung Cheung , Kenneth S.H. Chok
    Hepatorenal syndrome is not an uncommon life-threatening complication arising from liver cirrhosis. The diagnostic criteria for this syndrome have been revised throughout the years, with recent revisions aimed at improving earlier diagnosis and treatment. Liver transplantation remains the only... Read more
    Hepatoma Res 2017;3:67-72. | doi:10.20517/2394-5079.2016.48
    Published on: 12 Apr 2017  | Viewed:3387  | Downloaded:363
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  • Original Article|Open Access

    Late recurrence of hepatocellular carcinoma after liver transplantation

    Julia A. Zhang , Sandi A. Kwee , Linda L. Wong
    Aim: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and liver transplant (LT) prolongs survival. However, 15-20% will experience recurrent HCC, most occurring within 2 years of LT. HCC patients with late recurrences (> 5 years after LT) may have... Read more
    Hepatoma Res 2017;3:58-66. | doi:10.20517/2394-5079.2017.05
    Published on: 10 Apr 2017  | Viewed:1232  | Downloaded:101
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  • Original Article|Open Access

    Attenuation of liver stiffness in sorafenib-treated patients with advanced hepatocellular carcinoma

    Chien-Fu Hung , Dong Liu , Tsung-Han Wu , Chao-Wei Lee , Kuang-Tse Pan , Ching-Ting Wang , Hsiu-Ying Chai , Ming-Chin Yu , Yi-Cheng Chen
    Aim: Sorafenib is a multi-tyrosine kinase inhibitor and the standard therapy for advanced hepatocellular carcinoma (HCC). This retrospective study aimed to observe the anti-fibrotic effect of sorafenib in patients with advanced HCC. Methods: Seventeen patients with advanced HCC were recruited.... Read more
    Hepatoma Res 2017;3:52-7. | doi:10.20517/2394-5079.2016.43
    Published on: 24 Mar 2017  | Viewed:664  | Downloaded:69
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  • Topic: Novel Approaches for HCC|Open Access

    Immunotherapy for hepatocellular carcinoma: the force awakens in HCC?

    Lynn G. Feun , Ying-Ying Li , Medhi Wangpaichitr , Chun-Jing Wu , Niramol Savaraj
    Systemic therapy for hepatocellular carcinoma (HCC) has been disappointing. The only drug approved by Food and Drug Administration recently has been sorafenib. Sorafenib has modest benefits with a low response rate and an improvement in time to progression of only 2-3 months. Multiple randomized... Read more
    Hepatoma Res 2017;3:43-51. | doi:10.20517/2394-5079.2016.45
    Published on: 22 Mar 2017  | Viewed:1949  | Downloaded:587
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  • Original Article|Open Access

    Comparison of p53 and prohibitin expression in the spectrum of hepatitis, cirrhosis, and hepatocellular carcinoma

    Lívia Maria Della Porta , Fernando Silva Ramalho , Carlos Augusto Oliveira , Deisy Mara Silva , Marlei Josiele Augusto , Leandra Náira Zambelli Ramalho
    Aim: To investigate the correlation of p53 and prohibitin (PHB) expression in the spectrum of hepatitis, cirrhosis, and human hepatocellular carcinoma (HCC). Methods: Hepatic biopsies from patients with HCC (n = 60), cirrhosis (CIR, n = 30), hepatitis C virus (HCV, n = 30), and normal livers (NL,... Read more
    Hepatoma Res 2017;3:34-42. | doi:10.20517/2394-5079.2016.39
    Published on: 28 Feb 2017  | Viewed:987  | Downloaded:63
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  • Original Article|Open Access

    Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.) in hepatocellular carcinoma rats model

    Hanaa A. Hassan , Nermin E. Ghareb , Ghassan F. Azhari
    Aim: Oxidative damage of cellular components by free radicals and other reactive oxygen molecules is believed to be associated with the development of degenerative diseases. The aim of the present study was to evaluate the antioxidant capacity and free radical scavenging activity of cape... Read more
    Hepatoma Res 2017;3:27-33. | doi:10.20517/2394-5079.2016.33
    Published on: 28 Feb 2017  | Viewed:1243  | Downloaded:115
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  • Review|Open Access

    Further understanding of mechanisms involved in liver cancer chemoresistance

    Oscar Briz , Maria J. Perez , Jose J. G. Marin
    An important limitation for the success of chemotherapy in the treatment of primary liver cancer (hepatocellular carcinoma, hepatoblastoma and cholangiocarcinoma) is the marked efficacy of mechanisms of chemoresistance (MOC). These have been previously classified into five groups depending on... Read more
    Hepatoma Res 2017;3:22-6. | doi:10.20517/2394-5079.2016.22
    Published on: 19 Jan 2017  | Viewed:851  | Downloaded:177
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  • Case Report|Open Access

    Sorafenib from palliative to neoadjuvant chemotherapy in hepatocellular carcinoma with major vascular invasion: experience of two cases

    Naganathan Selvakumar , Sandeep Vohra , Deep Sika Arora , Subash Gupta
    Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the incidence is higher in cirrhosis. Treatment options depend on tumor stage, status of liver function, and the general condition of the patient. Major vascular invasion is a contraindication for liver... Read more
    Hepatoma Res 2017;3:18-21. | doi:10.20517/2394-5079.2016.14
    Published on: 12 Jan 2017  | Viewed:841  | Downloaded:72
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  • Review|Open Access

    Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

    Alba Castán , Ylenia Navarro , Luis Sarría , Raquel Larrosa , Mario Serradilla , Alejandro Serrablo
    Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively rare. Compared with HCC arising in cirrhotic livers they have some quirks. HCC in healthy livers are large tumors at diagnosis, and are detected due to the onset of abdominal symptoms, outside of any scheduled monitoring... Read more
    Hepatoma Res 2017;3:1-17. | doi:10.20517/2394-5079.2015.62
    Published on: 12 Jan 2017  | Viewed:4189  | Downloaded:235
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  • Review|Open Access

    Novel predictive and prognostic strategies of hepatitis B virus related hepatocellular carcinoma

    Wen-Bin Liu , Fan Yang , Ding-Yi Shao , Guang-Wen Cao
    Hepatocellular carcinoma (HCC) is a common malignancy and an important cause of cancer death worldwide. Chronic hepatitis B virus (HBV) infection is the major cause of HCC. Recent studies of HBV-induced carcinogenesis not only discovered many new biomarkers but also developed a novel theory:... Read more
    Hepatoma Res 2016;2:331-40. | doi:10.20517/2394-5079.2016.38
    Published on: 23 Dec 2016  | Viewed:1862  | Downloaded:119
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  • Original Article|Open Access

    Effect of obesity on perioperative outcomes after laparoscopic hepatectomy

    Seeyuen J. Lee , Adam Hauch , Erica Kane , Christoper DuCoin , Michael Darden , Geoffrey Parker , Emad Kandil , Joseph F. Buell
    Aim: Laparoscopic hepatectomy is increasing in utilization, however the procedure has not been adequately examined in the obese patient. This study aims to analyze the effect of obesity on perioperative outcomes after laparoscopic hepatectomy. Methods: Retrospective analysis of 396 laparoscopic... Read more
    Hepatoma Res 2016;2:323-7. | doi:10.20517/2394-5079.2016.34
    Published on: 13 Dec 2016  | Viewed:1010  | Downloaded:61
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  • Commentary|Open Access

    Comments on “The severity of non-alcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota”

    Anna Egresi , Krisztina Hagymási , Gabriella Lengyel
    Hepatoma Res 2016;2:328-30. | doi:10.20517/2394-5079.2016.31
    Published on: 13 Dec 2016  | Viewed:870  | Downloaded:81
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  • Original Article|Open Access

    Role of contrast-enhanced ultrasound in the evaluation of vascularization of hepatocellular carcinoma

    Francesco Loria , Giuseppe Loria , Salvatore Basile , Giuseppe Crea , Luciano Frosina , Francesca Frosina
    Aim: Early individualization of hepatocellular carcinoma is crucial to obtain good therapeutic results, thanks to several options such as percutaneous therapies, surgical resections and transplant. Aim of this study is to evaluate the vascularization of hepatocarcinoma using contrast enhanced... Read more
    Hepatoma Res 2016;2:316-22. | doi:10.20517/2394-5079.2016.27
    Published on: 22 Nov 2016  | Viewed:1238  | Downloaded:89
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  • Original Article|Open Access

    Evaluating normalization approaches for the better identification of aberrant microRNAs associated with hepatocellular carcinoma

    Jing Shen , Qiao Wang , Irina Gurvich , Helen Remotti , Regina M. Santella
    Aim: Dysregulated microRNAs (miRNAs) have been identified in hepatocellular carcinoma (HCC), but only a small proportion have been confirmed. An appropriate normalizer is crucial to determining the accuracy and reliability of data from miRNA studies. Methods: Different normalization strategies... Read more
    Hepatoma Res 2016;2:305-15. | doi:10.20517/2394-5079.2016.28
    Published on: 18 Nov 2016  | Viewed:1726  | Downloaded:91
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  • Case Report|Open Access

    Aggressive primary hepatic histiocytic sarcoma: case report and literature review

    Guang Yang , Jeremy Deisch , Haixia Qin , Craig Zuppan , Anwar S. Raza
    Histiocytic sarcoma is an uncommon non-Langerhans histiocyte disorder of mature tissue histiocytes. The authors presented an example of this rare tumor in a 14-year-old girl who presented with left upper quadrant pain, loss of appetite, and weight loss. A large 18 cm × 10 cm heterogeneous solid... Read more
    Hepatoma Res 2016;2:300-4. | doi:10.20517/2394-5079.2016.10
    Published on: 7 Nov 2016  | Viewed:1675  | Downloaded:68
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  • Case Report|Open Access

    An extra-adrenal pheochromocytoma mimicking a primary liver cancer

    Kenneth Siu Ho Chok , Florence Loong , Chung Mau Lo
    Despite doctors’ every effort to be vigilant when diagnosing, sometimes a preoperative diagnosis is disproved by postoperative pathological examination. A patient was diagnosed with hepatocellular carcinoma and received surgery as treatment. On operation, a solitary retroperitoneal mass rather... Read more
    Hepatoma Res 2016;2:297-9. | doi:10.20517/2394-5079.2016.04
    Published on: 7 Nov 2016  | Viewed:1661  | Downloaded:65
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  • Case Report|Open Access

    Hepatocarcinoma with metastasis to the anterior mediastinum

    Rogério Camargo Pinheiro Alves , Lorena Sagrilo Auer , Lisa Rodrigues da Cunha Saud , Raquel Coris Arrelaro , Aline Carboni Casado , Bruno Gustavo Ferreira , Denis Szjenfeld , Paula Bechara Poletti
    Liver malignancies are the sixth leading cause of cancer worldwide, whereas hepatocellular carcinoma (HCC) is the most frequent histological type of liver cancer. Extrahepatic metastasis, which rarely involves the mediastinum, is associated with poor prognosis. An 80-year-old male presenting with... Read more
    Hepatoma Res 2016;2:293-6. | doi:10.20517/2394-5079.2016.01
    Published on: 21 Oct 2016  | Viewed:1387  | Downloaded:109
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  • Original Article|Open Access

    Is transarterial embolization a valuable treatment option for spontaneous rupture of hepatocellular carcinoma: experience from a tertiary care hospital of South-Asia

    Amna Subhan Butt , Saeed Hamid , Nazish Butt , Fatima Sharif , Tanveer Ul Haq , Wasim Jafri
    Aim: Transarterial embolization (TAE) has been found beneficial in treatment of ruptured Hepatocellular carcinoma (HCC) in earlier studies. So far no data is available from Pakistan. The aim of this study was to evaluate clinicopathological characteristics, outcomes of patients presented with... Read more
    Hepatoma Res 2016;2:279-86. | doi:10.20517/2394-5079.2016.08
    Published on: 21 Oct 2016  | Viewed:2178  | Downloaded:127
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  • Case Report|Open Access

    Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis with an unusual presentation of abdominal compartment syndrome

    Li Lei , Camilla J. Cobb , Jeffrey Cao , Anwar S. Raza
    Hemophagocytic lymphohistiocytosis (HLH) is a cytokine storm syndrome caused by an overactive but ineffective immune reaction. Without prompt diagnosis and treatment, HLH is life-threatening. However, presenting symptoms are often nonspecific, with fatigue and fever being the most common. A high... Read more
    Hepatoma Res 2016;2:287-92. | doi:10.20517/2394-5079.2016.18
    Published on: 21 Oct 2016  | Viewed:1542  | Downloaded:69
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Liver resection for hepatocellular carcinoma within a fast-track management: a propensity-score matched analysis between open and laparoscopic approach

    Francesca Ratti , Federica Cipriani , Raffaella Reineke , Marco Catena , Michele Paganelli , Luigi Beretta , Luca Aldrighetti
    Aim: The study was designed to assess the implications of enhanced recovery after surgery (ERAS) approach in patients submitted to open liver resection for hepatocellular carcinoma (HCC) comparing their short term outcome with patients treated by laparoscopic approach, in a case-matched design.... Read more
    Hepatoma Res 2016;2:271-8. | doi:10.20517/2394-5079.2016.20
    Published on: 30 Sep 2016  | Viewed:1070  | Downloaded:67
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic resection of hepatocellular carcinoma in patients with and without cirrhosis: the Brisbane experience

    Daniel J. Kilburn , Universe Leung , David J. Cavallucci , Cassandra Jeavons , Mehan Siriwardhane , Richard Bryant , Thomas R. O’Rourke , Shinn Yeung , Nicholas A. O’Rourke
    Aim: Laparoscopic liver resection for hepatocellular carcinoma (HCC) is increasingly common around the world. There may be significant advantages over open resections. However, due to technical difficulties, they are performed in few centers with expertise in liver and advanced laparoscopic... Read more
    Hepatoma Res 2016;2:264-70. | doi:10.20517/2394-5079.2016.29
    Published on: 30 Sep 2016  | Viewed:1396  | Downloaded:106
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic liver resection for hepatocellular carcinoma in patients with cirrhosis

    Jai Young Cho , Ho-Seong Han
    Hepatocellular carcinoma (HCC) is a common malignant tumor and many cases occur in patients with liver cirrhosis. Although liver transplantation is the most effective treatment option, hepatectomy is still the first curative treatment option because liver transplantation is limited by the donors... Read more
    Hepatoma Res 2016;2:259-63. | doi:10.20517/2394-5079.2016.13
    Published on: 30 Sep 2016  | Viewed:1194  | Downloaded:103
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Case report of the fourth laparoscopic liver resection and review of repeat laparoscopic resection for recurrent hepatocellular carcinoma in cirrhotic liver

    Zenichi Morise , Masashi Isetani , Norihiko Kawabe Norihiko Kawabe , Hirokazu Tomishige , Hidetoshi Nagata , Satoshi Arakawa , Masahiro Ikeda , Kenshiro Kamio
    A 73-year-old woman with liver cirrhosis caused by hepatitis C virus (HCV) underwent treatment of three hepatocellular carcinomas (HCCs) in liver segment 4, following three previous laparoscopic liver resections (LLRs) over 73 months. Contrast-enhanced computed tomography showed three 0.5-1.2 cm... Read more
    Hepatoma Res 2016;2:253-8. | doi:10.20517/2394-5079.2016.09
    Published on: 19 Sep 2016  | Viewed:2049  | Downloaded:74
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Laparoscopic liver resection in the cirrhotic patient

    Ben Robichaux , Jesse Sulzer , Joseph F. Buell
    Aim: The adoption of laparoscopic liver resection has been expansive in the last 2 decades with the exception of cirrhotic patients. The current study examines the outcomes of our cirrhotic resections to determine the potential limitations of this technique. Methods: Retrospective analysis of 114... Read more
    Hepatoma Res 2016;2:248-52. | doi:10.20517/2394-5079.2016.23
    Published on: 19 Sep 2016  | Viewed:1208  | Downloaded:59
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Indications and technique for laparoscopic liver resection in patients with hepatocellular carcinoma and liver cirrhosis

    Yuichiro Otsuka , Masaru Tsichiya , Toshio Katagiri , Yoshihisa Kubota , Jun Ishii , Tetsuya Maeda , Hironori Kaneko
    Liver resection is the preferred initial treatment option for solitary or limited multifocal hepatocellular carcinoma (HCC). However, because of the characteristics of HCC, including its high recurrence rate and the frequent presence of chronic hepatitis and cirrhosis, both curability and... Read more
    Hepatoma Res 2016;2:241-7. | doi:10.20517/2394-5079.2016.11
    Published on: 19 Sep 2016  | Viewed:2006  | Downloaded:127
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  • Topic: Advances in Minimally Invasive Cirrhotic Surgery|Open Access

    Introduction of the special issue: “Advances in Minimally Invasive Cirrhotic Surgery”

    Giulio Belli
    Hepatoma Res 2016;2:239-40. | doi:10.20517/2394-5079.2016.16
    Published on: 19 Sep 2016  | Viewed:795  | Downloaded:55
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  • Original Article|Open Access

    Detecting hepatic nodules and identifying feeding arteries of hepatocellular carcinoma: efficacy of cone-beam computed tomography in transcatheter arterial chemoembolization

    Yasuhiro Ushijima , Tsuyoshi Tajima , Akihiro Nishie , Yoshiki Asayama , Kousei Ishigami , Masakazu Hirakawa , Daisuke Kakihara , Daisuke Okamoto , Hiroshi Honda
    Aim: To evaluate the effectiveness of using cone-beam computed tomography (CBCT) in transcatheter arterial chemoembolization (TACE) to detect hapatocellular carcinoma (HCC) nodules and their feeding arteries. Methods: Twenty-four patients with HCCs who underwent TACE using CBCT in addition to... Read more
    Hepatoma Res 2016;2:231-6. | doi:10.20517/2394-5079.2016.32
    Published on: 25 Aug 2016  | Viewed:1613  | Downloaded:88
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  • Commentary|Open Access

    Comment on “Preliminary outcome of microwave ablation of hepatocellular carcinoma: breaking the 3-cm barrier?”

    Paola Tombesi , Francesca Di Vece , Francesca Ermili , Sergio Sartori
    Hepatoma Res 2016;2:237-8. | doi:10.20517/2394-5079.2016.30
    Published on: 25 Aug 2016  | Viewed:1713  | Downloaded:73
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  • Review|Open Access

    Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma

    Hanaa Ali Hassan , Nermin E. El-Gharib , Anmar F. Azhari
    Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in... Read more
    Hepatoma Res 2016;2:216-23. | doi:10.20517/2394-5079.2016.12
    Published on: 5 Aug 2016  | Viewed:95827  | Downloaded:144
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  • Review|Open Access

    Diet and nutrition therapy in pre-liver transplant patients

    Neha Bakshi , Kalyani Singh
    Malnutrition is universally prevalent among pre-liver transplantation patients. Malnutrition among cirrhotic patients had been associated to increased morbidity and mortality rates. Also, severely malnourished patients before the transplant surgery have a higher rate of complications and a... Read more
    Hepatoma Res 2016;2:207-15. | doi:10.20517/2394-5079.2016.02
    Published on: 5 Aug 2016  | Viewed:4612  | Downloaded:191
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  • Original Article|Open Access

    Efficacy of sorafenib therapy in patients with advanced hepatocellular carcinoma in Indian population

    Alit Abraham , Charumathi Purushothaman , Dhanya Damien , Jackson James , Prudence Attilade Rodrigues , Gursharan Singh
    Aim: Hepatocellular carcinoma (HCC) is the fourth most common type of cancer and the third leading cause of cancer-related mortality. Sorafenib is an oral multikinase inhibitor that is used for unresectable advanced HCC. It is only approved systemic therapy for advanced HCC. Methods: A... Read more
    Hepatoma Res 2016;2:224-8. | doi:10.20517/2394-5079.2016.03
    Published on: 5 Aug 2016  | Viewed:1756  | Downloaded:117
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  • Letter to Editor|Open Access

    Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes

    Kunio Takegoshi , Eikichi Okada , Qin Su
    Hepatoma Res 2016;2:229-30. | doi:10.20517/2394-5079.2016.26
    Published on: 5 Aug 2016  | Viewed:1109  | Downloaded:93
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  • Review|Open Access

    Percutaneous hepatic perfusion with melphalan for unresectable liver metastasis

    Humair S. Quadri , Eden C. Payabyab , David J. Chen , William Figg , Marybeth S. Hughes
    Percutaneous hepatic perfusion (PHP) is an investigative technique for treating patients with diffuse unresectable metastatic liver disease. The technique has been clinically evaluated and shows great treatment potential for regional therapy to the liver. The advantage of PHP lies in its... Read more
    Hepatoma Res 2016;2:197-202. | doi:10.20517/2394-5079.2016.24
    Published on: 13 Jul 2016  | Viewed:3057  | Downloaded:144
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  • Brief Communication|Open Access

    Hepatic disorder in Zika virus infection

    Viroj Wiwanitkit
    Zika virus infection is the present global problem. This arbovirus infection can cause acute illness and affect fetus in utero. However, there can be other additional clinical manifestation including to the hepatic disorder. In this short commentary article, the author briefly discusses on the... Read more
    Hepatoma Res 2016;2:203-4. | doi:10.20517/2394-5079.2016.17
    Published on: 13 Jul 2016  | Viewed:1822  | Downloaded:251
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  • Commentary|Open Access

    Comment on "A series of microRNA in the chromosome 14q32.2 maternally imprinted region related to progression of non-alcoholic fatty liver disease in a mouse model”

    Pietro Di Fazio , Thaddeus Till Wissniowski
    Hepatoma Res 2016;2:205-6. | doi:10.20517/2394-5079.2016.19
    Published on: 13 Jul 2016  | Viewed:839  | Downloaded:59
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  • Review|Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard
    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host... Read more
    Hepatoma Res 2016;2:163-86. | doi:10.20517/2394-5079.2016.05
    Published on: 1 Jul 2016  | Viewed:20995  | Downloaded:796
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  • Case Report|Open Access

    Hemorrhagic cardiac tamponade after percutaneous laser ablation of a liver metastasis in segment II

    Paola Tombesi , Francesca Di Vece , Silvia Rinaldi , Matteo Bertini , Sergio Sartori
    Despite percutaneous laser thermal ablation (LTA) of liver tumors being regarded as a safe technique, major complications can occur. We report the first case of hemorrhagic cardiac tamponade after LTA of a colorectal metastasis in segment II of the liver. Unpredictable heat diffusion causing... Read more
    Hepatoma Res 2016;2:193-6. | doi:10.20517/2394-5079.2015.68
    Published on: 1 Jul 2016  | Viewed:1793  | Downloaded:64
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  • Original Article|Open Access

    Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study

    Hiroshi Yoshida , Hiroshi Makino , Tadashi Yokoyama , Hiroshi Maruyama , Atsushi Hirakata , Junji Ueda , Yasuhiro Mamada , Nobuhiko Taniai , Eiji Uchida
    Aim: The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the... Read more
    Hepatoma Res 2016;2:187-92. | doi:10.20517/2394-5079.2016.06
    Published on: 1 Jul 2016  | Viewed:2538  | Downloaded:155
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  • Original Article|Open Access

    Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

    Jing Shen , Abby B. Siegel , Helen Remotti , Qiao Wang , Regina M. Santella
    Aim: Deregulation of microRNAs (miRNAs) expression has been identified in hepatocellular carcinoma (HCC), but few results are consistent. The objective of this study is to investigate “HCC tumor type specific” and “tumor common” miRNA panels. Methods: The authors integrate and analyze clinical,... Read more
    Hepatoma Res 2016;2:151-62. | doi:10.20517/2394-5079.2015.66
    Published on: 1 Jun 2016  | Viewed:4174  | Downloaded:214
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  • Review|Open Access

    Physiological potential of cytokines and liver damages

    Fathia A. Mannaa , Khaled G. Abdel-Wahhab
    Cytokines are soluble extracellular small molecular weight protein or peptide. They are produced by virtually every nucleated cell type in response to injurious stimuli to control body metabolism, infection, inflammation and tissue or neuronal damage; therefore acting as messengers between... Read more
    Hepatoma Res 2016;2:131-43. | doi:10.20517/2394-5079.2015.58
    Published on: 1 Jun 2016  | Viewed:9461  | Downloaded:293
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  • Original Article|Open Access

    Hepatoprotective and antioxidant activity of Bombax ceiba flowers against carbon tetrachloride-induced hepatotoxicity in rats

    Manish M. Wanjari , Rachna Gangoria , Yadu Nandan Dey , Sudesh N. Gaidhani , Narendra K. Pandey , Ankush D. Jadhav
    Aim: The flowers of Bombax ceiba are traditionally used as home remedy in the treatment of jaundice and spleen enlargement. The present work investigated the effect of aqueous extract of flowers of Bombax ceiba (BCAE) on experimentally induced hepatotoxicity in rats to substantiate its... Read more
    Hepatoma Res 2016;2:144-50. | doi:10.20517/2394-5079.2015.55
    Published on: 1 Jun 2016  | Viewed:2959  | Downloaded:409
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  • Review|Open Access

    Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis

    Atul Ranjan , Kaustav Bera , Tomoo Iwakuma
    Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet, the mechanisms underlying HCC progression remain unclear. Unlike other cancers, systematic chemotherapy is not effective for HCC patients, while surgical resection and liver... Read more
    Hepatoma Res 2016;2:114-21. | doi:10.20517/2394-5079.2015.67
    Published on: 6 May 2016  | Viewed:2139  | Downloaded:117
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  • Review|Open Access

    Human telomerase disease mutants and its relation with hepatocarcinoma

    Yin-Nan Chen , Yan-Min Zhang
    Telomerase is a special reverse transcriptase, which adds telomeric DNA repeats to the ends of chromosome to offset loss. A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustain proliferation and growth. Hepatocellular carcinoma (HCC) is one of the most... Read more
    Hepatoma Res 2016;2:109-13. | doi:10.20517/2394-5079.2015.56
    Published on: 6 May 2016  | Viewed:1974  | Downloaded:145
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  • Original Article|Open Access

    Can gender predict virological response to standard antiviral therapy for chronic hepatitis C? A retrospective study

    Paola Belci , Alessandro Collo , Maria Martorana , Andrea Evangelista , Sara Giunti , Roberto Gambino , Maurizio Cassader , Simona Bo , Marilena Durazzo
    Aim: The liver is a sexually dimorphic organ presenting gender differences in its metabolism, functions, enzyme activity, membrane lipid composition and immune response. This paper aimed to assess whether gender may predict virological response to standard antiviral therapy in subjects with... Read more
    Hepatoma Res 2016;2:122-30. | doi:10.20517/2394-5079.2015.53
    Published on: 6 May 2016  | Viewed:1446  | Downloaded:64
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  • Original Article|Open Access

    Surgical resection or radiofrequency ablation in the management of hepatocellular carcinoma: single center experience

    Wael Mansy , Morsi Mohammed , Sameh Saber
    Aim: The aim of this study is to prove or disprove the superiority of surgical resections over radiofrequency ablation (RFA) with respect to efficacy and safety. Methods: The study was conducted in Zagazig University Hospitals, which included 40 patients with hepatocellular carcinoma (HCC) during... Read more
    Hepatoma Res 2016;2:92-7. | doi:10.4103/2394-5079.169642
    Published on: 1 Apr 2016  | Viewed:3386  | Downloaded:116
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  • Case Report|Open Access

    Spontaneous rupture of hepatocellular carcinoma

    Amer Hawatmeh , Khalid Jumean , Ahmed Abu Arqoub , Hamid Shaaban
    This is a very interesting case of a 64-year-old female with a history of chronic hepatitis C infection, with abdominal pain and was found to have ruptured hepatocellular carcinoma (HCC). She was managed with the two-stage therapeutic approach first using transarterial embolization to provide... Read more
    Hepatoma Res 2016;2:103-6. | doi:10.4103/2394-5079.171207
    Published on: 1 Apr 2016  | Viewed:2123  | Downloaded:154
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  • Original Article|Open Access

    Arterial blood supply of hepatocellular carcinoma is associated with efficacy of sorafenib therapy

    Xiang-Hua Zhang , Qian Zhu , Jing Li , Liang Huang , Jian-Jun Yan , Feng Xu , Jun Li , Yi-Qun Yan
    Aim: There are some previous reports concerning the relationship between prognosis of patients treated with sorafenib and parameters of computed tomography (CT) and magnetic resonance imaging (MRI). This study presents monocentric experience with sorafenib in the treatment of hepatocellular... Read more
    Hepatoma Res 2016;2:87-91. | doi:10.4103/2394-5079.170542
    Published on: 1 Apr 2016  | Viewed:1119  | Downloaded:114
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  • Case Report|Open Access

    Nutrition profile of a liver transplant recipient

    Neha Bakshi , Kalyani Singh
    Malnutrition is almost universally present in patients undergoing liver transplantation. In this report, a male adult patient was followed from his pre-liver transplant phase until chronic post-transplant phase (3 months after the transplant). Improvement in nutrition status, quality of life, and... Read more
    Hepatoma Res 2016;2:98-102. | doi:10.4103/2394-5079.168958
    Published on: 1 Apr 2016  | Viewed:2227  | Downloaded:73
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  • Letter to Editor|Open Access

    Microwave coagulation therapy: the future is quite rosy

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Hepatoma Res 2016;2:107-8. | doi:10.4103/2394-5079.170543
    Published on: 1 Apr 2016  | Viewed:1078  | Downloaded:41
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet

    Mosaad A. Abdel-Wahhab , Olivier Joubert , Aziza A. El-Nekeety , Hafiza A. Sharaf , Ferial M. Abu-Salem , Bertrand H. Rihn
    Aim: This study aimed to determine the composition of ethanol extract of jojoba seeds, and to evaluate its hepatoprotective effects in rats fed fumonisin B1 (FB1)-contaminated diet. Methods: Jojoba seeds were extracted in 95% ethanol, and the chemical composition was determined. Male rats were... Read more
    Hepatoma Res 2016;2:78-86. | doi:10.4103/2394-5079.168078
    Published on: 9 Mar 2016  | Viewed:2868  | Downloaded:203
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Coffee, Traditional Chinese Medicine and cannabinoids as potential tools for prevention and treatment of hepatocellular carcinoma

    Stefano Gitto , Ranka Vukotic , Pietro Andreone
    In the last decade, the incidence of hepatocellular carcinoma (HCC) is growing in both Europe and United States. Conventional therapies such as liver resection, transplantation, ablation, chemoembolization and sorafenib are not enough to avoid a significant mortality. Many studies suggested the... Read more
    Hepatoma Res 2016;2:71-7. | doi:10.20517/2394-5079.2015.63
    Published on: 9 Mar 2016  | Viewed:2062  | Downloaded:117
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Curcumin: an adjuvant therapeutic remedy for liver cancer

    Shilpa Sharma , Anshul Tanwar , Devendra K. Gupta
    The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is a high associated morbidity and mortality due to advanced stages, adverse... Read more
    Hepatoma Res 2016;2:62-70. | doi:10.20517/2394-5079.2015.59
    Published on: 9 Mar 2016  | Viewed:7613  | Downloaded:321
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Beneficial and detrimental effects of natural dietary products on the risk of hepatocellular carcinoma, and their roles in its management

    Rodolfo Sacco , Caterina Conte , Sara Marceglia , Valeria Mismas , Giampaolo Bresci , Antonio Romano , Roberto Eggenhoffner , Luca Giacomelli
    Hepatocellular carcinoma (HCC) is a common solid malignancy and a leading cause of cancer-related death worldwide. The mechanisms underlying the pathogenesis and development of HCC are complex and heterogeneous. Although mainly related to hepatitis B and C chronic infection; HCC may also arise... Read more
    Hepatoma Res 2016;2:53-61. | doi:10.20517/2394-5079.2015.64
    Published on: 9 Mar 2016  | Viewed:3716  | Downloaded:171
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  • Original Article|Open Access

    Predictive factors for the success of “one-off” ablation in single hepatocellular carcinoma patients who underwent percutaneous radiofrequency ablation

    Jian-Yun Long , Jing Li , Jie Cao , Liang Huang , Xiang-Hua Zhang , Jin-Kai Liu , Yi-Qun Yan
    Aim: To investigate the technique' s effectiveness and evaluate the risk factors affecting the success of "one-off" percutaneous ultrasound-guided radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC). Methods: A total of 462 consecutive patients who received RFA from February... Read more
    Hepatoma Res 2016;2:47-52. | doi:10.4103/2394-5079.172726
    Published on: 29 Feb 2016  | Viewed:1170  | Downloaded:62
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  • Original Article|Open Access

    Fascin-1 depletion from hepatocellular carcinoma cells inhibits migfilin and vasodilator-stimulated phosphoprotein expression and enhances adhesiona

    Vasiliki Gkretsi , Dimitrios P. Bogdanos
    Aim: Extracellular matrix (ECM)-adhesions and their interaction with actin cytoskeleton are fundamental for hepatocellular carcinoma (HCC). Fascin-1, an actin-bundling protein, is correlated with poor HCC prognosis, and is known regarding the molecular mechanism of its action. In this study, the... Read more
    Hepatoma Res 2016;2:42-6. | doi:10.4103/2394-5079.168071
    Published on: 29 Feb 2016  | Viewed:1194  | Downloaded:59
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  • Original Article|Open Access

    Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

    Adam Hauch , Carl Winkler , Eric Katz , Peter W. Lundberg , Mary Killackey , Anil S. Paramesh , Luis A. Balart , Nathan J. Shores , Martin Moehlen , Ward Miller , Douglas P. Slakey , Joseph F. Buell , Bob H. Saggi
    Aim: Portal vein thrombosis (PVT) in the liver transplant recipient poses many challenges. Unfortunately, the risk factors and effects on outcomes of PVT are not well-defined. Methods: This study analyzed the experience with PVT in liver transplant program from 2007 to 2013. This included the... Read more
    Hepatoma Res 2016;2:36-41. | doi:10.4103/2394-5079.168070
    Published on: 29 Feb 2016  | Viewed:2363  | Downloaded:68
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  • Review|Open Access

    Recent updates of genetic and genomic alterations in hepatocellular carcinoma

    Zhang Zhao , Jian Huang
    Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide. However, the molecular mechanisms underlining the development and progression of HCC remain unclear. Genetic and genomic alterations are common events in various types of cancers including HCC. With the... Read more
    Hepatoma Res 2016;2:31-5. | doi:10.4103/2394-5079.168446
    Published on: 29 Feb 2016  | Viewed:1213  | Downloaded:119
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  • Review|Open Access

    Role of antiviral therapy in patients with chronic hepatitis B or C virus in preventing the development of hepatocellular carcinoma

    Laura Scribano , Veronica Vanin , Giorgia Gottardo , Diana Sacchi , Francesco Paolo Russo
    Patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are at significant risk for hepatocellular carcinoma (HCC). The most important risk factor associated with HCC is liver cirrhosis, which is again predominantly caused by chronic HBV or HCV infection. The most... Read more
    Hepatoma Res 2016;2:10-7. | doi:10.4103/2394-5079.168961
    Published on: 15 Jan 2016  | Viewed:1846  | Downloaded:171
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  • Review|Open Access

    Interventional radiology therapies for liver cancer

    Romaric Loffroy , Louis Estivalet , Sylvain Favelier , Pierre Pottecher , Pierre-Yves Genson , Jean-Pierre Cercueil , Denis Krausé
    Hepatocellular carcinoma (HCC) is the fifth most frequently found primary malignant tumor in the world. Hepatic surgery and liver transplantation are considered optimal for the curative treatment of HCC. However, only 15-20% of HCCs may be surgically treated. Most of the surgically-non-eligible... Read more
    Hepatoma Res 2016;2:1-9. | doi:10.4103/2394-5079.167439
    Published on: 15 Jan 2016  | Viewed:1375  | Downloaded:140
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  • Original Article|Open Access

    Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

    Mohamed Ahmed Samy Kohla , Om Kolsoum Al-Haddad , Ali Nada , Mohamed Al-Warraky , Manar Obada , Mohamed Amer , Sameera Ezzat , Ashraf Abou Gabal
    Aim: Epidermal growth factor (EGF) is a mitogen for hepatocyte grown in vitro, and its expression is up-regulated during liver regeneration. EGF also plays an important role in tumor initiation and progression. The goal of this study is to assess whether EGF is associated with advanced... Read more
    Hepatoma Res 2016;2:18-25. | doi:10.4103/2394-5079.168959
    Published on: 15 Jan 2016  | Viewed:2783  | Downloaded:106
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  • Case Report|Open Access

    Hepatocellular carcinoma and type 2 diabetes mellitus: two cases highlighting changes in tumor glycogen content

    Kunio Takegoshi , Eikichi Okada , Kazuhiro Nomoto , Kouji Nobata , Takuro Sawasaki , Mitsuhiro Terada , Hirofumi Terakawa , Takashi Kobayashi , Kazuhisa Yabushita , Tatsuho Sugimoto , Shintaro Terahata
    This article reports two patients with hepatocellular carcinoma (HCC) and type 2 diabetes mellitus (T2DM), who showed marked changes in hepatocellular glycogen content. Periodic acid-Schiff (PAS)-positive and diastase-PAS-negative (glycogen-storing) hepatocytes were detected in both background... Read more
    Hepatoma Res 2016;2:26-30. | doi:10.4103/2394-5079.168725
    Published on: 15 Jan 2016  | Viewed:1614  | Downloaded:81
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

    Hanaa A. Hassan , Hanaa M. Serag , Nabil M. Abdel-Hamid , Mahmoud M. Amr
    Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a... Read more
    Hepatoma Res 2015;1:147-54. | doi:10.4103/2394-5079.167376
    Published on: 15 Oct 2015  | Viewed:6368  | Downloaded:289
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Protective effects of Amaranthus hybridus against aflatoxin B1 and fumonisin B1-induced genotoxicity in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Protective effects of aqueous extract of Amaranthus hybridus against aflatoxin B1 (AFB1) and/or fumonisin B1 (FB1) on the H4IIE-luc cell line were determined by use of the methyl thiazol tetrazolium viability assay and disruption of DNA integrity. Methods: H4IIE-luc cells were incubated with... Read more
    Hepatoma Res 2015;1:136-46. | doi:10.4103/2394-5079.167377
    Published on: 15 Oct 2015  | Viewed:6254  | Downloaded:163
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Preventive role of chamomile flowers and fennel seeds extracts against liver injury and oxidative stress induced by an immunosuppressant drug in rats

    Fathia A. Mannaa , Nagi A. Ibrahim , Soliman S. Ibrahim , Khaled G. Abdel-Wahhab , Nabila S. Hassan , Saida G. Mohammed
    Aim: The present study was conducted to investigate the protective effect of chamomile flowers methanolic extract (CFME) and fennel seeds methanolic extract (FSME) on azathioprine (AZA), an immunosuppressant drug, which induced a liver injury and oxidative stress in rats. Methods: Rats were... Read more
    Hepatoma Res 2015;1:125-35. | doi:10.4103/2394-5079.167375
    Published on: 15 Oct 2015  | Viewed:8064  | Downloaded:283
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma: a review

    Asma M. Alnajjar , Hussien A. Elsiesy
    Hepatocellular carcinoma (HCC) is the fifth commonest cause of malignancy and the third cause of cancer mortality. There are different treatment options for HCC ranging from loco-regional therapy to surgical treatment. Different regimen of systemic chemotherapy has been tried with a poor... Read more
    Hepatoma Res 2015;1:119-24. | doi:10.4103/2394-5079.167379
    Published on: 15 Oct 2015  | Viewed:5488  | Downloaded:299
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

    Mohamed A. Hamzawy , Ezzeldein S. M. El-Denshary , Mosaad A. Abdel-Wahhab
    Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases... Read more
    Hepatoma Res 2015;1:111-8. | doi:10.4103/2394-5079.167378
    Published on: 15 Oct 2015  | Viewed:6098  | Downloaded:413
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  • Review|Open Access

    “PERISH” flowchart for selection of the patients with resectable hepatocellular carcinoma

    Cuneyt Kayaalp , H. Kerem Tolan , Mehmet Caglikulekci
    A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms/staging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always diffi culties in remembering and/or recalling the contents of... Read more
    Hepatoma Res 2015;1:165-70. | doi:10.4103/2394-5079.161329
    Published on: 15 Oct 2015  | Viewed:18224  | Downloaded:259
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?

    Jing Li , Liang Huang , Yi-Qun Yan
    Hepatoma Res 2015;1:109-10. | doi:10.4103/2394-5079.161332
    Published on: 15 Oct 2015  | Viewed:40904  | Downloaded:201
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  • Review|Open Access

    Microwave coagulation therapy of hepatocellular carcinoma

    Yong-Song Guan
    Microwave coagulation therapy (MCT) is a relatively new method of tumor ablation compared to other minimally invasive local therapies for hepatocellular carcinoma (HCC). It is a thermal ablation modality based on the application of heat, potentially leading to larger ablation zones. In recent... Read more
    Hepatoma Res 2015;1:159-64. | doi:10.4103/2394-5079.164648
    Published on: 15 Oct 2015  | Viewed:6858  | Downloaded:225
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  • Topic: Natural Products and Hepatocellular Carcinoma|Open Access

    Natural products and hepatocellular carcinoma

    Mosaad A. Abdel-Wahhab
    Hepatoma Res 2015;1:107-8. | doi:10.4103/2394-5079.161626
    Published on: 15 Oct 2015  | Viewed:4688  | Downloaded:115
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  • Review|Open Access

    Expectations for partial splenic arterial embolization simultaneous transcatheter arterial chemoembolization for hepatocellular carcinoma

    Toru Ishikawa
    Hepatocellular carcinoma (HCC) is frequently complicated by cirrhosis, and it is not unusual for treatment options to be limited as a result of pancytopenia due to hypersplenism. Partial splenic embolization (PSE) has been performed for thrombocytopenia resulting from hypersplenism. However, the... Read more
    Hepatoma Res 2015;1:155-8. | doi:10.4103/2394-5079.161284
    Published on: 15 Oct 2015  | Viewed:7055  | Downloaded:141
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  • Original Article|Open Access

    Sorafenib suppresses hepatitis B virus gene expression via inhibiting JNK pathway

    Hyun Kook Cho , Ju Ran Kim , So Young Kim , Yi Yi Kyaw , Aye Aye Win , Jae Hun Cheong
    Aim: Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases. Sorafenib is a multikinase inhibitor and an approved anti-liver cancer drug. Here we demonstrated the antiviral effect of sorafenib on HBV gene expression. Methods: To investigate the effect of sorafenib on HBV... Read more
    Hepatoma Res 2015;1:97-103. | doi:10.4103/2394-5079.158391
    Published on: 15 Jul 2015  | Viewed:8148  | Downloaded:100
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  • Original Article|Open Access

    Long-term immune-modulatory side effects of radiofrequency ablation in patients with liver metastases and hepatocellular carcinoma

    Thaddeus Till Wissniowski , Thomas Gress , Pietro Di Fazio
    Aim: Used as a palliative therapy for unresectable liver cancer, radiofrequency ablation (RFA) is associated with the induction of immunological responses. Here, we show strong evidence of tumor-specific peripheral blood mononuclear cells (PBMCs) 12 months after RFA. Methods: Three patients with... Read more
    Hepatoma Res 2015;1:92-6. | doi:10.4103/2394-5079.158024
    Published on: 15 Jul 2015  | Viewed:6856  | Downloaded:92
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  • Editorial|Open Access

    Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique?

    Paola Tombesi , Francesca Di Vece , Sergio Sartori
    Hepatoma Res 2015;1:52-7. | doi:10.4103/2394-5079.155697
    Published on: 15 Jul 2015  | Viewed:7155  | Downloaded:262
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  • Original Article|Open Access

    Laparoscopic radiofrequency ablation for hepatocellular carcinoma

    Anna Sánchez-López , Anna Pallisera-Lloveras , Ramon Saiz-Mendiguren , Manuel Ferrer-Marsal , José Carlos Vicens-Arbona , José Andrés Cifuentes-Ródenas , Jose Manuel Ramia
    Aim: The optimal treatment for hepatocellular carcinoma (HCC) is either surgical resection or liver transplantation, but only one-third of the patients are suitable candidates for surgery. Laparoscopic radiofrequency ablation (RFA) in selected patients is a safe, feasible technique, which has... Read more
    Hepatoma Res 2015;1:86-91. | doi:10.4103/2394-5079.157692
    Published on: 15 Jul 2015  | Viewed:8083  | Downloaded:107
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  • Editorial|Open Access

    Preneoplastic foci in mice fed diethyl 1, 4-dihydro, 1, 4, 6-trimethyl 3, 5-pyridine decarboxylate are resistant to protoporphyrin accumulation

    Samuel W. French , M. Waheed Roomi
    Hepatoma Res 2015;1:50-1. | doi:10.4103/2394-5079.155984
    Published on: 15 Jul 2015  | Viewed:5317  | Downloaded:92
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  • Review|Open Access

    Hepatoma and trematode infestation: a short review

    Viroj Wiwanitkit
    Hepatoma is a common cancer that can be seen around the world and clinical correlation between infection and hepatoma is evident. Hepatitis virus infection is proved for its relationship with hepatoma. However, the knowledge of other infections is still limited. In this short review, the... Read more
    Hepatoma Res 2015;1:63-6. | doi:10.4103/2394-5079.158390
    Published on: 15 Jul 2015  | Viewed:6426  | Downloaded:76
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  • Original Article|Open Access

    Aqueous extract of Corchorus olitorius decreases cytotoxicity of aflatoxin B1 and fumonisin B1 in H4IIE-luc cells

    Mohamed I. M. Ibrahim , Rialet Pieters , Sekena H. Abdel-Aziem , Anna M. van der Walt , Cornelius C. Bezuidenhout , John P. Giesy , Mosaad A. Abdel-Wahhab
    Aim: Afl atoxin B1 (AFB1) and fumonisin B1 (FB1) are important food-borne mycotoxins. Co-contamination of foodstuffs with these two mycotoxins is well-known and has been implicated in a possible development of hepatocellular carcinoma in humans living in regions of the world where exposures to... Read more
    Hepatoma Res 2015;1:75-85. | doi:10.4103/2394-5079.155692
    Published on: 15 Jul 2015  | Viewed:8210  | Downloaded:165
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  • Editorial|Open Access

    The evolving role of laparoscopic ablation

    Joseph F. Buell
    Hepatoma Res 2015;1:49. | doi:10.4103/2394-5079.159519
    Published on: 15 Jul 2015  | Viewed:6143  | Downloaded:95
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  • Review|Open Access

    Hepatocellular carcinoma in elderly patients: a concise review on systemic therapy with sorafenib

    Lombardi Giuseppe , Vitale Alessandro , Sara Lonardi , Bellu Luisa , Pambuku Ardi , Marsico Valentina , Crivellari Gino , Aliberti Camillo , Cillo Umberto , Zagonel Vittorina
    The treatment of hepatocellular carcinoma (HCC) in elderly patients is unclear. In particular, the efficacy and safety of sorafenib as a systemic treatment in these patients is still under debate. We performed a concise review of sorafenib therapy in this population. However, it is important to... Read more
    Hepatoma Res 2015;1:58-62. | doi:10.4103/2394-5079.157695
    Published on: 15 Jul 2015  | Viewed:7371  | Downloaded:153
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  • Original Article|Open Access

    Anti-proliferative and apoptotic effificacy of diallyl disulfide on Ehrlich ascites carcinoma

    Osama M. Ahmed , Rasha R. Ahmed
    Aim: This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfide (DADS) against Ehrlich ascites carcinoma (EAC) and to suggest its probable mechanism of action. Methods: EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock... Read more
    Hepatoma Res 2015;1:67-74. | doi:10.4103/2394-5079.157602
    Published on: 15 Jul 2015  | Viewed:9337  | Downloaded:194
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  • Case Report|Open Access

    Resection of hepatocellular carcinoma after combined treatment with transarterial chemoembolization and sorafenib: a case report and literature review

    Kenneth Siu Ho Chok , Ian Yu Hong Wong , See Ching Chan , Ronnie Tung Ping Poon , Chung Mau Lo
    Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) invasion and metastatic lymph node metastases has a poor prognosis, and surgical resection is seldom indicated. We report how an initially unresectable HCC in a 36-year-old Chinese male with distant lymph node metastases and tumor... Read more
    Hepatoma Res 2015;1:104-6. | doi:10.4103/2394-5079.155694
    Published on: 15 Jul 2015  | Viewed:5195  | Downloaded:131
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  • Original Article|Open Access

    Salvage transplantation for post-resection recurrence in hepatocellular carcinoma associated with hepatitis C virus etiology: a feasible strategy?

    Bhavin Bhupendra Vasavada , Chao-Long Chan
    Aim: The aim was to analyze the feasibility of salvage liver transplant after liver resection in hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) etiology. Methods: All the patients diagnosed with HCC with HCV etiology who underwent living donor liver transplant from July 2002 to... Read more
    Hepatoma Res 2015;1:36-40. | doi:10.4103/2394-5079.152916
    Published on: 15 Apr 2015  | Viewed:7866  | Downloaded:143
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  • Editorial|Open Access

    The evolving role of transarterial chemoembolization in themanagement of hepatocellular carcinoma

    Georgios Tsoulfas
    Hepatoma Res 2015;1:9-10. | doi:10.4103/2394-5079.153287
    Published on: 15 Apr 2015  | Viewed:5675  | Downloaded:90
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  • Original Article|Open Access

    Repeat liver surgery by laparoscopy for a malignant recurrence after previous open or laparoscopic resection

    Luigi Cioffi , Andrea Belli , Corrado Fantini , Alberto D'Agostino , Gianluca Russo , Giulio Belli
    Aim: This paper reported the experience of one center on repeat laparoscopic liver surgery for metastasis and hepatocellular carcinoma (HCC) with a review of the literature. Methods: This retrospective study included 24 patients who underwent laparoscopic re-intervention (hepatic resection and... Read more
    Hepatoma Res 2015;1:30-5. | doi:10.4103/2394-5079.153915
    Published on: 15 Apr 2015  | Viewed:7704  | Downloaded:161
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  • Editorial|Open Access

    Laparoscopic hepatectomy in cirrhotic patients with hepatocellular carcinoma: technical aspects and potential benefits

    Osamu Itano , Takuya Minagawa , Yuko Kitagawa
    Hepatoma Res 2015;1:6-8. | doi:10.4103/2394-5079.153786
    Published on: 15 Apr 2015  | Viewed:5699  | Downloaded:100
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  • Original Article|Open Access

    Role of diabetes mellitus on the recurrence rate of hepatocellular carcinomas after radiofrequency ablation in chronic hepatitis C patients

    Abd Allah Ahmed El-Sawy , Mohamed Abd El-Raouf Tawfik
    Aim: The aim was to assess the impact of hyperglycemia on the recurrence of hepatocellular carcinoma (HCC) as well as evaluate survival after curative ablation by radiofrequency. Methods: This study, which was conducted retrospectively on 107 chronic hepatitis C (CHC) patients with 159 HCCs, was... Read more
    Hepatoma Res 2015;1:24-9. | doi:10.4103/2394-5079.154356
    Published on: 15 Apr 2015  | Viewed:7290  | Downloaded:124
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  • Case Report|Open Access

    Successful living donor liver transplantation in a cystic fibrosis patient with combined hepatocellular carcinoma and cholangiocarcinoma

    Falk Rauchfuß , Felix Dondorf , René Fahrner , Michael Ardelt , Yves Dittmar , Utz Settmacher
    Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is a rare tumor entity. In this report, we describe a case of a young patient who developed a liver tumor in a cirrhotic liver caused by cystic fibrosis. All diagnostic findings suggested that this tumor was an HCC. We performed... Read more
    Hepatoma Res 2015;1:46-8. | doi:10.4103/2394-5079.153288
    Published on: 15 Apr 2015  | Viewed:5091  | Downloaded:106
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  • Editorial|Open Access

    Hepatoma Research: the beginning of a new forum

    Joseph F. Buell
    Hepatoma Res 2015;1:1-5. | doi:10.4103/2394-5079.153290
    Published on: 15 Apr 2015  | Viewed:7303  | Downloaded:167
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  • Review|Open Access

    Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease

    Kevin M. Sokolowski , Mariappan Balamurugan , Selvi Kunnimalaiyaan , T. Clark Gamblin , Muthusamy Kunnimalaiyaan
    The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base. One such cancer, primary liver cancer, is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative... Read more
    Hepatoma Res 2015;1:11-8. | doi:10.4103/2394-5079.154132
    Published on: 15 Apr 2015  | Viewed:9915  | Downloaded:278
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  • Original Article|Open Access

    Combined radiofrequency and chemoembolization vs. chemoembolization in management of hepatocellular carcinoma

    Ahmed Kamal El Dorry , Eman Mahmoud Fathy Barakat , Amal Tohamy Abd ElMoez , Mervat Abd Fatah Mawad , Nevien Fouad El-Fouly , Mohamed Kamal Shaker
    Aim: Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. If left untreated, liver cancer has a poor prognosis with more than 90% of patients dying of the disease within 5 years of diagnosis. The aim of this study is to assess the value of combined radiofrequency... Read more
    Hepatoma Res 2015;1:19-23. | doi:10.4103/2394-5079.154355
    Published on: 15 Apr 2015  | Viewed:7257  | Downloaded:161
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  • Case Report|Open Access

    Combined sarcomatoid hepatocellular and cholangiocarcinoma: a case report and literature review

    Julian Shun Tsang , Kenneth Siu Ho Chok , Rex Kwok Him Au-Yeung , Chung Mau Lo
    Hepatic sarcomatoid carcinomas are very rare. The majority of cases contain sarcomatoid features with either hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) elements alone. These are aggressive tumors and carry an unfavorable prognosis. We describe an extremely rare tumor sub-type of... Read more
    Hepatoma Res 2015;1:41-5. | doi:10.4103/2394-5079.154331
    Published on: 15 Apr 2015  | Viewed:7244  | Downloaded:171
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Hepatoma Research Print ISSN: 2394-5079; Online ISSN: 2454-2520
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