• image 20 Nov 2017 Review| Open Access

    Role of early growth response 1 in liver metabolism and liver cancer

    Nancy Magee , Yuxia Zhang

    The liver is an essential organ for nutrient and drug metabolism - possessing the remarkable ability to sense environmental and metabolic stimuli and provide an optimally adaptive response. Early growth response 1 (Egr1), an immediate early transcriptional factor which acts as a coordinator of...

    Hepatoma Research [HTML] [PDF] Viewed:20 Downloaded:3
  • image 16 Nov 2017 Topic: Reversing X Chromosome Inactivation as a New Therapeutic Treatment for X-linked Diseases| Open Access

    Reversal of X chromosome inactivation: lessons from pluripotent reprogramming of mouse and human somatic cells

    Irene Cantone

    X chromosome inactivation (XCI) is a strategy used by mammals to silence genes along one of the two female X chromosomes and equilibrate expression dosage between XY males and XX females. This epigenetically-inherited silencing is established during early embryonic development and maintained...

    Journal of Translational Genetics and Genomics [HTML] [PDF] Viewed:90 Downloaded:3
  • image 14 Nov 2017 Technical Note| Open Access

    Development and applications of acquisition techniques for rat pancreatic imaging at clinical scanners

    Ting Yin , Ronald Peeters , Jie Yu , Yicheng Ni

    Rat models are frequently used in preclinical studies on the pancreatic diseases. However, non-invasive imaging of rat pancreatic models has been hampered by the small size of the pancreas and the unpredictable motion artifacts in rat abdomen. Being widely accessible and of translational...

    Journal of Unexplored Medical Data [HTML] [PDF] Viewed:71 Downloaded:2
  • image 31 Oct 2017 Topic: Cancer Immunotherapy| Open Access

    Cell-mediated immunotherapy for hepatocellular carcinoma

    Wei-Chen Lee

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Most of the time, these tumors are diagnosed at late stages. Because no effective treatments exist for patients with advanced stage HCC, there is an urgent need for novel, effective treatments. Cancer cells originate as a...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:175 Downloaded:10
  • image 34190 Topic: Infectious Disease of Central Nervous System| Open Access

    Current diagnosis and treatment of cryptococcal meningitis without acquired immunodeficiency syndrome

    Xiao-Su Guo , Hui Bu , Jun-Ying He , Yue-Li Zou , Yue Zhao , Yuan-Yuan Li , Jun-Zhao Cui , Ming-Ming Zheng , Wei-Xin Han , Ze-Yan Zhao

    Cryptococcal meningitis (CM) is a central nervous system infectious disease caused by Cryptococcus. It is the most common fungal infection in the central nervous system, accounting for about 48% of fungal infection. The disease occurs mainly in acquired immunodeficiency syndrome (AIDS) patients...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:34190 Downloaded:275
  • image 209099 Review| Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo

    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:209099 Downloaded:653
  • image 20557 Topic: Biomaterials for Plastic and Aesthetic Surgery| Open Access

    Intradermal fillers for minimally invasive treatment of facial aging

    Zhi Yuan (William) Lin , Vishva Shah , Arvind Dhinakar , Lara Yildirimer , Wen-Guo Cui , Xin Zhao

    The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses...

    Plastic and Aesthetic Research [HTML] [PDF] Viewed:20557 Downloaded:989
  • image 24309 Review| Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard

    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host...

    Hepatoma Research [HTML] [PDF] Viewed:24309 Downloaded:855
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